A5090387399- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- Neuroscience and Neural Engineering
- Vagus Nerve Stimulation Research
- Stroke Rehabilitation and Recovery
- Neural dynamics and brain function
- Respiratory and Cough-Related Research
- Visual perception and processing mechanisms
- Neurological disorders and treatments
- Neurobiology and Insect Physiology Research
- Neural and Behavioral Psychology Studies
- Machine Learning in Materials Science
- Functional Brain Connectivity Studies
- Urinary Bladder and Prostate Research
- Cardiac Arrhythmias and Treatments
- ECG Monitoring and Analysis
Duke University
2025
Battelle
2022-2024
University of Wisconsin–Madison
2019-2020
Abstract Objective Seventy-five percent of stroke survivors, caregivers, and health care professionals (HCP) believe current therapy practices are insufficient, specifically calling out the upper extremity as an area where innovation is needed to develop highly usable prosthetics/orthotics for population. A promising method controlling technologies infer movement intention non-invasively from surface electromyography (EMG). However, existing often limited research settings struggle meet user...
Abstract Objective Clinical data suggest that efficacious vagus nerve stimulation (VNS) is limited by side effects such as cough and dyspnea have thresholds lower than those for therapeutic outcomes. VNS are putatively caused activation of nearby muscles within the neck, via direct muscle or fibers innervating muscles. Our goal was to determine at which various VNS-evoked occur in domestic pig—an animal model with anatomy similar human—using bipolar helical lead deployed clinically. Approach...
Implanted neural stimulation and recording devices hold vast potential to treat a variety of neurological conditions, but the invasiveness, complexity, cost implantation procedure greatly reduce access an otherwise promising therapeutic approach. To address this need, novel electrode that begins as uncured, flowable prepolymer can be injected around neuroanatomical target minimize surgical manipulation is developed. Referred Injectrode, conforms structures forming electrically conductive...
Potentially damaging “heart stress” is reversed using reactive nerve stimulation controlled by artificial intelligence.
Abstract Non-invasive, high-density electromyography (HD-EMG) has emerged as a useful tool to collect range of neurophysiological motor information. Recent studies have demonstrated changes in EMG features that occur after stroke, which correlate with functional ability, highlighting their potential use biomarkers. However, previous largely explored these isolation individual electrodes assess gross movements, limiting clinical utility. Here, able-bodied (N=7) and chronic stroke subjects...
Background: Functional electrical stimulation (FES) has been recognized for decades as a method to retrain the motor system after stroke. Benefits of FES rehabilitation can be enhanced by combining with task-oriented rehabilitation, dubbed therapy (FEST). Furthermore, synchronizing user's volitional intention and incorporating multiple trained tasks, better integrated into common practice. Using wearable technology, we tested these elements in two chronic stroke survivors (subjects A, B)....
Abstract Objective. Non-invasive, high-density electromyography (HD-EMG) has emerged as a useful tool to collect range of neurophysiological motor information. Recent studies have demonstrated changes in EMG features that occur after stroke, which correlate with functional ability, highlighting their potential use biomarkers. However, previous largely explored these isolation individual electrodes assess gross movements, limiting clinical utility. This study aims predict hand function stroke...
Natural scenes often contain multiple objects and surfaces. However, how neurons in the visual cortex represent stimuli is not well understood. Previous studies have shown that, when compete one feature domain, evoked neuronal response biased toward stimulus that has a stronger signal strength. We recorded from two male macaques to investigate middle temporal (MT) more than domain. Visual were random-dot patches moving different directions. One had low luminance contrast moved with high...
Abstract Implanted neural stimulation and recording devices hold vast potential to treat a variety of neurological conditions, but the invasiveness, complexity, cost implantation procedure greatly reduce access an otherwise promising therapeutic approach. To address this need, we have developed novel electrode that begins as uncured, flowable pre-polymer can be injected around neuroanatomical target minimize surgical manipulation. Referred Injectrode, conforms structures forming electrically...
Abstract Clinical data suggest that efficacious vagus nerve stimulation (VNS) is limited by side effects such as cough and dyspnea have thresholds lower than those for therapeutic outcomes. VNS are putatively caused activation of nearby muscles within the neck, via direct muscle or fibers innervating muscles. Our goal was to determine at which various VNS-evoked occur in domestic pig—an animal model with anatomy similar human—using bipolar helical lead deployed clinically. Intrafascicular...
The Injectrode is an in-body curing material that forms electrode contact with nerves to enable minimally-invasive neuromodulation. artwork depicts the spirit of Kip A. Ludwig's, Andrew J. Shoffstall's, and co-workers' effort in article number 1900892; bridge electrical pulses from outside body on inside. In this case, a representation vagus nerve.
ABSTRACT Natural scenes often contain multiple objects and surfaces. However, how neurons in the visual cortex represent stimuli is not well understood. Previous studies have shown that, when compete one feature domain, evoked neuronal response biased toward stimulus that has a stronger signal strength. Here we investigate middle temporal (MT) of macaques more than domain. Visual were two random-dot patches moving different directions. One had low luminance contrast moved with high...