A5078026836- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Long-Term Effects of COVID-19
- RNA modifications and cancer
- Macrophage Migration Inhibitory Factor
- RNA Research and Splicing
- Adenosine and Purinergic Signaling
- Inflammation biomarkers and pathways
23andMe (United States)
2024
Gladstone Institutes
2022
University of California, Berkeley
2021
University of Washington
2020
Coronavirus disease 2019 (COVID-19) is frequently associated with neurological deficits, but how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces these effects remains unclear. Here, we show that astrocytes are readily infected by SARS-CoV-2, surprisingly, neuropilin-1, not angiotensin-converting enzyme (ACE2), serves as the principal receptor mediating cell entry. Infection further positively modulated two-pore segment channel (TPC2) protein regulates membrane...
Early blastomeres of mouse preimplantation embryos exhibit bi-potential cell fate, capable generating both embryonic and extra-embryonic lineages in blastocysts. Here we identify three major two-cell-stage (2C)-specific endogenous retroviruses (ERVs) as the molecular hallmark this plasticity. Using long terminal repeats (LTRs) all 2C-specific ERVs, Krüppel-like factor 5 (Klf5) their upstream regulator. Klf5 is essential for fate; a single Klf5-overexpressing stem (ESC) generates terminally...
The wide prevalence and regulated expression of long noncoding RNAs (lncRNAs) highlight their functional roles, but the molecular basis for activities structure-function relationships remains to be investigated, with few exceptions. Among relatively lncRNAs conserved over significant evolutionary distances is intergenic RNA (lincRNA) Cyrano (orthologous human OIP5-AS1), which contains a region 300 highly nucleotides within tetrapods, in turn stretch 26 nt deep conservation. This binds...
Abstract 23ME-00610 is a monoclonal antibody that being evaluated as single agent in Phase 1/2a clinical trial for advanced solid malignancies (NCT05199272). It binds with high affinity (KD < 0.1 nM) to CD200R1, promising immune-oncology (IO) target identified by surveying the 23andMe genetic and health survey database. CD200R1 an inhibitory receptor when bound its ligand CD200, reduces pro-inflammatory cytokine production, leads immunosuppressive tumor environment. To gain further...
Summary Early blastomeres of mouse preimplantation embryos exhibit bi-potential cell fate, capable generating both embryonic and extra-embryonic lineages in blastocysts. Here, we identified three major 2 (2C) specific endogenous retroviruses (ERVs) as the molecular hallmark plasticity. Using LTRs all 2C-ERVs, Klf5 their upstream regulator. is essential for fate: a single Klf5-overexpressing ESC generated terminally differentiated chimeric embryos, directly induces ICM TE specification genes....