A5009120161- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Blood groups and transfusion
- Cancer-related gene regulation
- Galectins and Cancer Biology
- Erythrocyte Function and Pathophysiology
- Immunotherapy and Immune Responses
- Parvovirus B19 Infection Studies
- Glycosylation and Glycoproteins Research
Brigham and Women's Hospital
2023
Harvard University
2023
Oncode Institute
2018
The Netherlands Cancer Institute
2018
The histone methyltransferase Dot1 is conserved from yeast to human and methylates lysine 79 of H3 (H3K79) on the core nucleosome. H3K79 methylation by affects gene expression response DNA damage, enhanced monoubiquitination C-terminus H2B (H2Bub1). To gain more insight into functions Dot1, we generated genetic interaction maps increased-dosage alleles DOT1. We identified a functional relationship between increased dosage loss DUB module SAGA co-activator complex, which deubiquitinates...