A5004625800- Forensic Toxicology and Drug Analysis
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Advanced Chemical Sensor Technologies
- Analytical Chemistry and Chromatography
- Analytical chemistry methods development
- Spectroscopy Techniques in Biomedical and Chemical Research
- Pesticide Residue Analysis and Safety
- Urban Stormwater Management Solutions
- Gut microbiota and health
- Substance Abuse Treatment and Outcomes
- Gas Sensing Nanomaterials and Sensors
- Analytical Methods in Pharmaceuticals
- Cannabis and Cannabinoid Research
- Lung Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Forensic Fingerprint Detection Methods
- Lung Cancer Treatments and Mutations
- Urban Heat Island Mitigation
- Smart Materials for Construction
- Electrochemical sensors and biosensors
- Poisoning and overdose treatments
- Opioid Use Disorder Treatment
- Biochemical Analysis and Sensing Techniques
- Insect Pheromone Research and Control
University of Victoria
2020-2024
Vancouver Island University
2018-2024
Thompson Rivers University
2016
Drug checking services for harm reduction and overdose prevention have been implemented in many jurisdictions as a public health intervention response to the opioid crisis. This study demonstrates first on-site use of paper spray mass spectrometry quantitative drug address limitations current testing technologies.
In British Columbia, Canada, illicit opioids have been increasingly combined with etizolam, a benzodiazepine analog, that continues to challenge popular portable drug checking technologies as it is often present in low concentrations result of its high potency. An unknown combination and benzodiazepines may dangerous consequences due unpredictable dosing, increased respiratory depression, complicated overdose response measures.Surface-enhanced Raman spectroscopy (SERS) using spectrometer...
Drug checking uses analytical chemistry technologies to report on the composition of drugs from unregulated market reduce substance use-related risks, while additionally allowing for monitoring and reporting supply. In context an overdose crisis linked fentanyl, we used drug data examine variability within illicit opioid supply.In this time-series analysis, was collected a service in Victoria, Canada November 2020 July 2021. Drugs reported as opioids by participants (N = 454) were analyzed...
There has been a recent increase in adulteration of opioids with low concentration actives such as fentanyl analogues and benzodiazepines. As drug checking projects using vibrational spectroscopy continue to seek confirmatory lab-based testing, the concern reality missing these potentially harmful substances point-of-care testing is prevalent.A portable GC-MS was used analyze select opioid samples acquired at service Victoria, Canada (n=59). Certified reference standards several...
Monitoring the atypical antipsychotic drug clozapine is crucial to ensure patient safety. This article showcases a high-throughput analytical method for measuring and its primary metabolite norclozapine (N-desmethylclozapine) in serum using paper spray mass spectrometry (PS-MS). study aimed assess viability of PS-MS rapid measurement human samples as an alternative liquid chromatography (LC-MS). Serum were processed by protein precipitation followed deposition supernatant containing labelled...
A direct mass spectrometry method utilizing reactive paper spray ionization was developed for sensitive cannabinoid quantitation in biofluid matrices. The ca. 2-minute sample measurements used on-paper derivatization to significantly increase (PS-MS) positive ion mode sensitivity while minimizing preparation steps. Calibrations demonstrate high linearity, with R2 > 0.99 (-)-trans-Δ9-tetrahydrocannabinol (THC) oral fluid and 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THC-COOH) urine. limit of...
Carfentanil is one of the most potent synthetic opioids ever developed, with an estimated analgesic potency approximately 20-100 times that fentanyl and 10,000 morphine. has been appearing in illicit drug supply many regions linked to fatal overdose events. A subset 59 street samples obtained Victoria, B.C., were confirmed contain carfentanil analyzed by mass spectrometry for this study. quantitation paper spray ranged from 0.05 2.95 w/w% (median = 0.32%) original sample. Paper analysis also...
Abstract Paper spray mass spectrometry is presented as a direct, quantitative tool for the measurement of pharmaceutical drugs and variety fentanyl analogs in solid samples powder slurries with ultimate goal providing meaningful harm‐reduction drug checking. Method development validation was carried out analog proxy street samples. Lower limits quantitation were determined to be 3.6‐7.4 ng/g slurry matrix. Using 1 mg sample, method can quantify picogram quantities these drugs, well below...
Post-separation addition of chemical modifiers in liquid chromatography-mass spectrometry is widely used for improving ionization sensitivity and selectivity. This typically accomplished using a post-column T-junction, which can result sample dilution imperfect mixing. We present passive semi-permeable hollow fiber membrane approach the that avoids these issues.Model compounds were directly infused by flow injection to an electrospray triple quadrupole mass spectrometer after passing through...
Abstract The Peppermint Initiative, established within the International Association of Breath Research, introduced peppermint protocol, a breath analysis benchmarking effort designed to address lack inter-comparability outcomes across different sampling techniques and analytical platforms. Benchmarking with gas chromatography—ion mobility spectrometry (GC-IMS) using has been previously reported however, coupling micro-thermal desorption ( µ TD) GC-IMS not yet, benchmarked for analysis. To...
Abstract Exhaled breath volatile organic compounds (VOCs) are often collected and stored in sorbent tubes before thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS) analysis. Information about the stability of VOCs during storage is needed to account for potential artifacts monitor losses. Additionally, information VOC standards solution required assess their performance as quality control internal standards. We evaluated a standard mixture 42 dual-sorbent containing Tenax® TA...
Rapid and accurate etizolam detection using surface-