A5045136764- Trypanosoma species research and implications
- Malaria Research and Control
- Research on Leishmaniasis Studies
- Biochemical and Molecular Research
- Mosquito-borne diseases and control
- Zoonotic diseases and public health
- Global Maternal and Child Health
- Parasites and Host Interactions
- Peptidase Inhibition and Analysis
- Insect symbiosis and bacterial influences
- Insect Pest Control Strategies
- Child Nutrition and Water Access
- Signaling Pathways in Disease
- Insect Utilization and Effects
- Animal and Plant Science Education
- Drug-Induced Hepatotoxicity and Protection
- Insect Resistance and Genetics
- Parasitic Infections and Diagnostics
- Hepatitis Viruses Studies and Epidemiology
- Helminth infection and control
- Neurobiology and Insect Physiology Research
- Parasite Biology and Host Interactions
- Viral Infections and Outbreaks Research
- Plant Virus Research Studies
Gulu University
2019-2024
Uppsala University Hospital
2020-2024
Lira Hospital
2024
Bridge University
2024
Karolinska Institutet
2006-2019
Science for Life Laboratory
2011
George Washington University
2005
Center for Infectious Disease Research
2005
University of Washington
2005
Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that diploid genome contains a predicted 22,570 proteins encoded by genes, which 12,570 represent allelic pairs. Over 50% consists repeated sequences, such as retrotransposons and genes for large families surface molecules, include trans-sialidases, mucins, gp63s, novel family (>1300 copies) mucin-associated protein (MASP) genes. Analyses T. cruzi, brucei , Leishmania major (Tritryp) genomes imply differences...
Trypanosoma cruzi is the causative agent of Chagas disease, which affects more than 9 million people in Latin America. We have generated a draft genome sequence TcI strain Sylvio X10/1 and compared it to TcVI reference CL Brener identify lineage-specific features. found virtually no differences core gene content by presence/absence analysis, but 6 open reading frames from were missing X10/1. Several multicopy families, including DGF, mucin, MASP GP63 contain substantially fewer genes X10/1,...
Trypanosoma cruzi marinkellei is a bat-associated parasite of the subgenus Schizotrypanum and it regarded as T. subspecies. Here we report draft genome sequence c. comparison with cruzi. Our aims were to identify unique sequences genomic features, which may relate their distinct niches. The was found be ~11% smaller than that human-derived Sylvio X10. size difference attributed copy number variation coding non-coding sequences. divergence in regions ~7.5% between A acetyltransferase gene...
To determine the prevalence of Plasmodium falciparum multi-drug resistant gene-1 (Pfmdr-1) N86Y and D1246Y genotypes among febrile malaria outpatients attending Lira Regional Referral Hospital, Uganda.Overall, 92.3% (n = 48/52) 90% 45/50) parasites detected carried wild type alleles 1246D N86, respectively. Only 7.7% 4/52) 10% 5/50) these P. isolates Pfmdr-1 mutant 1246Y 86Y, Our results show high N86 D1246 in from which could translate to a decreased sensitivity artemether-lumefantrine....
Ruspolia differens (Serville) (Orthoptera: Tettigoniidae), also known as the 'edible grasshopper', 'African edible bush-cricket', and 'nsenene', is regarded one of most promising insect species that can be used for food, particularly in Sub-Saharan Africa. However, there insufficient information on suitable diets their effects survival, adult weight, fecundity, developmental time this species, which are preconditions large-scale production. In study, we experimentally evaluated 12 (wheat...
Hookworm infection in expectant mothers has adverse health effects on both the and their unborn babies. Foetal are known to include intrauterine growth retardation physical mental retardation, while may develop anemia which could potentially result death. Unfortunately, little is about factors that predispose a pregnant woman by hookworm. In this study, we strived determine not only prevalence of hookworm among women attending first antenatal visit during current pregnancy local center...
<title>Abstract</title> Background Vector control interventions using long-lasting insecticidal nets and indoor residual spraying are common tools deployed for the of malaria in Uganda. To evaluate effectiveness these understand prevailing vectors, a study was conducted to determine species composition, resting population density, biting pattern vectors Indoor Residual Spraying non-Indoor districts Lira Kole, Northern Methods Both outdoor adult were collected from August September 2022...
Background: Malaria remains the leading cause of hospitalization and death in healthcare system. This study explored malaria burden community response to government control programs Omoro district. Method: retrospective involved 576 patient results from purposely selected health facilities data center III (HCIII) Odek, Bobi, Lapainat IV (HCIV) Lalogi. And prospective random section 288 participants Lutori Lagude cells Atyang A Lagwaya villages who consented answer pretested questionnaire....
Malaria during pregnancy contributes to significant perinatal morbidity and mortality, accounting for almost 25% of global maternal mortality. However, the epidemiology risk factors subclinical malaria among pregnant women living in refugee settlements is poorly understood.
Protein N-terminal acetylation is a co- and posttranslational modification, conserved among eukaryotes. It determines the functional fate of many proteins including their stability, complex formation, subcellular localization. acetyltransferases (NATs) transfer an acetyl group to N-termini proteins, major NATs in yeast humans are NatA, NatB, NatC. In this study, we characterized Trypanosoma cruzi ( T. cruzi) NatC NatA protein complexes, each consisting one catalytic subunit predicted...
Abstract Background The government of Uganda have implemented several malaria controls programs like Indoor Residual Spraying, use Insecticide Treated Nets, tests and treat strategy, IPT for pregnant women, introduction Village Health Teams to manage fevers radio TV education on prevention control. However, is still the leading cause hospitalization death in our health systems. This study explored burden community response control Omoro district. Method retrospective perspective involved 576...
Malaria remains one of the most critical disease causing morbidity and mortality in Uganda. Indoor residual spraying (IRS) use insecticide-treated bed nets are currently predominant malaria vector control interventions. However, emergence spread insecticide resistance among vectors threaten continued effectiveness these interventions to disease, particularly high transmission areas. To inform decisions on control, current study evaluated Anopheles species their susceptibility levels 0.1%...