Polycystic ovary syndrome (PCOS) is associated with psychological and metabolic disturbances. The aim of this study was to determine whether depression, anxiety reduced health-related quality life (HRQOL) are more common in women PCOS risk. included 226 patients 85 BMI-matched healthy control women. All participants completed standardized questionnaires assessing depression (Beck Depression Inventory), (State-Trait Anxiety Inventory) both (Hospital Scale General Health Questionnaire)....

Diabetic foot is a serious complication of diabetes mellitus and the risk lower extremity amputation very high in this population when compared with people without diabetes. We have previously reported lower-extremity rate significant factors determining risks for patients who had been admitted to Hacettepe University Hospital, tertiary reference center Turkey, between years 1992 1996. In January 2000, diabetic care team including an infectious diseases specialist, orthopaedic surgeons,...

Summary Objective We aimed to investigate whether fasting and meal regulated glucagon like peptide 1 ( GLP ‐1) secretion are altered in patients with polycystic ovary syndrome PCOS ) compared healty women oral contraceptive use influence ‐1 dynamics the syndrome. Design Prospective observational study. Patients Fourteen lean normal glucose tolerant 11 age‐ body mass index BMI )‐matched healthy women. Measurements Glucagon 1, insulin levels were measured during a standardized tolerance test...

Hashimoto's thyroiditis is the most frequent autoimmune thyroid disease. L-thyroxine therapy can reduce incidence and alleviate symptoms of this The aim study was to evaluate effects prophylactic treatment on clinical laboratory findings patients who were euthyroid at time diagnosis. Thirty-three had diagnosis randomized two groups, one group received other followed-up without treatment. Initial function tests, autoantibodies, ultrasonography, fine needle aspiration biopsy peripheral blood...

Androgens appear to play a role in the development of acne, and presence acne is potential marker hyperandrogenism.The authors evaluated androgens insulin sensitivity markers before after treatment with isotretinoin women post-adolescent severe who do not have hirsutism and/or ovulatory dysfunction.Androgens, lipids, glucose levels were measured 26 patients 21 controls during oral tolerance test. Homeostasis model assessment for resistance, area under curve (AUC)glucose AUCinsulin...

Ghrelin is an orexigenic peptide that stimulates food intake, whereas YY (PYY) and cholecystokinin (CCK) are anorexigenic gut hormones. Patients with polycystic ovary syndrome (PCOS) appear to have alterations in appetite regulation.We aimed determine whether fasting or meal-stimulated ghrelin, PYY, CCK, satiety responses different between lean PCOS patients healthy women. We also assess the potential effect of oral contraceptive use on these hormones response.We conducted a prospective...

The primary objective of the present study was to further elucidate effects oxcarbazepine (OXC) and levetiracetam (LEV) monotherapies on bone health status patients with epilepsy.This included 48 who attended our epilepsy outpatient clinic, had a diagnosis epilepsy, were undergoing either OXC or LEV monotherapy 42 healthy control subjects. demographic clinical features patients, including gender, age, onset disease, daily drug dosage, duration noted. Additionally, calcium, ionized 25-OH...

Background/aim: The purpose of this study was to analyze the clinicopathological characteristics patients with papillary thyroid carcinoma (PTC) and microcarcinoma (PTMC) predictive factors for central lymph node metastasis (CLNM).Materials methods: Patients diagnosed as having PTC PTMC were evaluated. Clinical laboratory parameters recorded.Results: mean age at diagnosis 47.3 +- 11.9 years. Of all 223 patients, 91 (40.8%) had nodes removed, 29 whom 24 only CLNM. Univariate analysis revealed...

Pigment epithelium-derived factor (PEDF) has anti-angiogenic, immunomodulatory and anti-inflammatory properties. In addition to the significant role it plays in reducing diabetic complications, PEDF is now used treatment of certain cancers. It possibly a insulin resistance cases, too. However, whether metformin any effects on levels not known. this study, we investigated regulation type 2 diabetes relation fat mass before after use for treatment.Prospective cohort study.Thirty-six patients...

The utilization of live microorganisms as therapeutics has been gaining increasing attention over the last years with addition scientific knowledge on their traditional uses. Probiotics are defined "live micro‑organisms which when administered in adequate amounts, confer a health benefit host". normal intestinal microbiota prevents colonization pathogenic bacteria and important immune functions. It hypothesized that sudden change parallels modern life practices humans might have contributed...

Isotretinoin, the drug of choice for severe acne, might be associated with a decrease in insulin sensitivity. Adiponectin is an adipose tissue-derived protein that increases In this study, we aimed to investigate adiponectin levels postadolescent acne and effect isotretinoin on levels.Participants included 18 female patients healthy women matched age body mass index (BMI). Acne completed 6-month treatment. Anthropometric measurements, serum adiponectin, lipids, fasting glucose, insulin,...

Purpose – The purpose of this paper is to demonstrate burnout syndrome among internal medicine and pediatrics residents in a country that does not have the working time directive (WTD) also determine risk factors consequent impact on efficient functioning clinical areas. Design/methodology/approach A 57-item questionnaire was given residents. Responses from 22 33 were evaluated. Findings Demographic findings, scores, having hobbies, social activities reading books unrelated similar between...

Legg-Calve-Perthes disease (LCPD) is a self-limited microvascular disorder leading to the occlusion of femoral blood supply, which results in bone necrosis. Endothelial injury and hemostatic alterations may play role compromise decreased flow, occur during course LCPD. Global fibrinolytic capacity (GFC) novel assay reflecting overall fibrinolysis response resulting from dynamic interactions numerous stimulatory inhibitory molecules. Circulating soluble thrombomodulin (TM) reflects...

Whole Body Vibration (WBV) is a type of exercise commonly applied as modern technique. The purpose the present study was to examine effects WBV for 10-week on strength, flexibility and agility in taekwondo athletes. A total 23 healthy young males participated study. athletes were separated randomly into two groups control group (n=11) whole body vibration training (n=12). did 3 days week 10 weeks. Control Group not do any trainings. hand grip strength test, vertical jump sit-reach t-test...

The clinical course of inflammatory bowel disease (IBD) is frequently associated with thromboembolic complications. aim this study was to investigate common thrombophilic markers in Turkish patients active IBD. Twenty-seven consecutive IBD who were followed-up at the Hacettepe University Hospital recruited. All state. International normalized ratio, activated partial thromboplastin time, lupus anticoagulant, anticardiolipin IgG, IgM antibodies, protein C, S, antithrombin-III, factor V, and...

Background:Metabolic syndrome (MS) has become a pandemic in Turkey, as is the case globally. Increase carotid artery intima-media thickness (CIMT) and erectile dysfunction (ED) may be evident before clinical signs of cardiovascular disease appear. We aimed to investigate prevalence increased CIMT ED markers atherosclerotic patients with MS. Material andMethods:Thirty-two MS 29 healthy controls were included. Anthropometric biochemical parameters, along total testosterone (TT), high sensitive...

Legg-Calve-Perthes disease (LCPD) is still an enigma. Hemostatic abnormalities have been indicated in the pathogenesis. We had previously demonstrated enhanced tissue factor pathway inhibitor response, increased global fibrinolytic capacity, and increase thrombomodulin patients with LCPD compared healthy individuals. These studies emphasized role of vascular endothelium pathogenesis LCPD. P-selectin expressed on activated platelets endothelial cells, E-selectin cells. The aim this study was...

Objective: Type 1 diabetes and autoimmune thyroid disease are commonly associated. Few studies have addressed islet-cell autoimmunity its relation with glucose homeostasis in Hashimoto's thyroiditis. The aims of this study were: (1) to determine the prevalence autoimmunity, (2) compare insulin sensitivity secretion patterns between normal tolerant glutamic acid decarboxylase antibodies (GA-D-Ab) positive negative patients thyroidi-tis. Methods: Two hundred fifty-three consecutive thyroiditis...