Genc Hasanaj
A5108061659- Retinal Imaging and Analysis
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Machine Learning in Healthcare
- Neuroscience and Neuropharmacology Research
- Glaucoma and retinal disorders
- Stress Responses and Cortisol
- Retinal Diseases and Treatments
LMU Klinikum
2022-2024
Ludwig-Maximilians-Universität München
2022-2024
Schizophrenia spectrum disorders (SSDs) are presumed to be associated with retinal thinning. However, evidence is lacking as whether these alterations reflect a disease-specific process or rather consequence of comorbid diseases concomitant microvascular impairment.The study included 126 eyes 65 patients SSDs and 143 72 healthy controls. We examined macula optic disc measures by optical coherence tomography (OCT) OCT angiography (OCT-A). Additive mixed models were used assess the impact on...
Schizophrenia (SCZ) is a highly heritable brain disorder marked by wide range of changes throughout the central nervous system. These include alterations at molecular and cellular levels, suggesting significant disruptions in synapse function, as well modifications structure activity. However, it remains unclear, how biology translate into neurophysiological ultimately behavioral consequences across scales. Here, we narrow this translational gap contemporary biological psychiatry...
According to the excitation-inhibition imbalance theory, GABAergic and glutamatergic systems influence clinical symptoms particularly cognitive deficits in schizophrenia spectrum disorders (SSD). These have been found disrupted anterior cingulate cortex (ACC) dorsolateral prefrontal (DLPFC) SSD, are associated with P300 abnormalities electroencephalography recordings. Therefore, we explored relationships among MRS-derived GABA Glx levels ACC left DLPFC (lDLPFC), auditory amplitudes...
Background: Schizophrenia spectrum disorders (SSD) present substantial clinical and biological heterogeneity, impeding advances in diagnostic precision personalised treatment. Despite consistent evidence of brain alterations, interindividual variability the predominance single-modality neuroimaging analyses hinder identification subgroups reflecting disorders' complexity. We developed a novel meta-analytically anchored clustering approach integrating structural (T1-weighted, diffusion tensor...
Introduction Treatment of severe mental illness (SMI) symptoms, especially negative symptoms and cognitive dysfunction in schizophrenia, remains a major unmet need. There is good evidence that SMIs have strong genetic background are characterized by multiple biological alterations, including disturbed brain circuits connectivity, dysregulated neuronal excitation-inhibition, dopaminergic glutamatergic pathways, partially inflammatory processes. The ways which the signaling pathways...
Previous studies have suggested that choroid plexus (ChP) enlargement occurs in individuals with schizophrenia-spectrum disorders (SSD) and is associated peripheral inflammation. However, it unclear whether such an delineates a biologically defined subgroup of SSD. Moreover, remains elusive how ChP linked to brain regions inflammation A cross-sectional cohort 132 SSD 107 age-matched healthy controls (HC) underwent cerebral magnetic resonance imaging (MRI) clinical phenotyping investigate the...