A5002272897- Silk-based biomaterials and applications
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Tryptophan and brain disorders
- Phytochemical compounds biological activities
- COVID-19 Clinical Research Studies
- Electrospun Nanofibers in Biomedical Applications
- Essential Oils and Antimicrobial Activity
- Artificial Intelligence in Healthcare and Education
- Microencapsulation and Drying Processes
- SARS-CoV-2 and COVID-19 Research
- Nanoparticle-Based Drug Delivery
- Ethnobotanical and Medicinal Plants Studies
- Antimicrobial Peptides and Activities
- Treatment of Major Depression
- Crystallization and Solubility Studies
- Morinda citrifolia extract uses
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Biochemical effects in animals
- RNA Interference and Gene Delivery
- Cancer-related cognitive impairment studies
- Biochemical and Structural Characterization
- Natural Antidiabetic Agents Studies
- Stress Responses and Cortisol
University of Kashmir
2021-2025
JSS Academy of Higher Education and Research
2017-2021
CT Group Of Institutions
2020-2021
Silk fibroin (SF) is a natural polymeric biomaterial that widely adopted for the preparation of drug delivery systems. Herein, we aimed to fabricate and characterize SF nanoparticles loaded with selective estrogen receptor modulator; tamoxifen citrate (TC-SF-NPs) assess their in vitro efficacy against breast cancer cell lines (MCF-7 MDA-MB-231). TC-loaded SF-NPs were characterized particle size, morphology, entrapment efficiency, release profile. In addition, examined cytotoxicity TC-SF-NPs...
Depression is a common mood disorder characterized by persistent sadness and loss of interest. Research suggests an association between the inclusion omega-3 fatty acids in diet reduced risk for depression. The present study evaluated effectiveness acid supplements alleviating depressive symptoms patients with mild to moderate A total 165 suffering from moderated depression were randomized receive supplementation, antidepressant (single agent), or combination supplementation. clinical...
Skimmia anquetilia is a plant species native to the Western Himalaya region that has tremendous potential for phytochemical activities. This study aimed identify bioactive compounds and assess antibacterial activity of S. anquetilia. To determine major chemicals in methanol leaf extract anquetilia, we used gas chromatography-mass spectrometer (GC-MS). The presence 35 distinct phytoconstituents was discovered using GC-MS, which could contribute therapeutic capabilities this species. most...
Despite decades of research, breast cancer therapy remains a great challenge. Docetaxel is an antimicrotubule agent that effectively used for the treatment cancer. However, its clinical use significantly hampered by low water solubility and systemic toxicity. The current study was designed to prepare docetaxel (DXL)-loaded silk-fibroin-based nanoparticles (SF-NPs) screen their potential antitumor activity against cell lines. DXL-loaded SF-NPs were prepared using nanoprecipitation technique...
The goal of this research is to study the prevalence cognitive impairment in diabetes mellitus (DM) patients and establish necessity detecting treating it early these patients. A cross-sectional was conducted at a tertiary care hospital Mysuru for 4 months examined diabetic (test) nondiabetic subjects (control) decline using Montreal Cognitive Assessment (MoCA) tool. functions such as visuospatial/executive function, naming, attention, language, abstraction, delayed recall, orientation were...
BCS class II molecules suffer from low oral bioavailability because of their poor permeability and sub-optimal aqueous solubility. One the approaches to enhance is using cyclodextrin-based nanosponges. This study aimed optimise evaluate feasibility a microwave-assisted approach synthesise nanosponges improve domperidone’s solubility drug delivery potential. In production process, microwave power level, response speed, stirring speed were optimised Box-Behnken approach. Ultimately, batch with...
Abstract Background Multidrug-resistant bacterial strains cause several serious infections that can be fatal, such as Enterococcus faecium , Staphylococcus aureus Klebsiella pneumonia Acinetobacter baumannii Pseudomonas aeruginosa and Enterobacteriaceae (often referred to ESKAPE pathogens). Since ancient times, indigenous medical systems in India have utilized diverse medicinal plants (approximately 80,000 species) conventional treatments for a variety of illnesses. A member the Fabaceae...
To assess the PharmD student's experiences about end year clerkship evaluation conducted using Objective Structured Clinical Exam (OSCE) format at JSS College of Pharmacy, Mysuru, India. The were captured a newly developed, 14-item, 5-point Likert's scale feedback form. results analyzed and presented descriptively. Mann-Whitney U test was used to compare responses between sex, entry level for performance in exam, whereas Spearman's rank correlation coefficient measure strength association...
The present study aimed to perform phytochemical investigation of various fractions the aerial parts Senecio laetus Edgew for its bio-constitution and pharmacologically evaluate these antioxidant antiproliferative activities against breast cancer (MCF-7) colon carcinoma (HCT-116) cell lines. Phytochemical screening characterization compounds was carried out as per standard procedures. Extracts were subjected GC-MS analysis identification constituents. activity using DPPH, ferric ion reducing...
The solubility of the poorly soluble drug raloxifene hydrochloride (3) in binary {dimethyl sulfoxide (DMSO) (1) + water (2)} mixtures have been recorded at several temperatures under atmospheric pressure. Four different computational models were applied to model experimental values studied drug. Raloxifene mole fraction was improved with higher temperature and DMSO mass {(DMSO) compositions. Pure had maximum (5.05 × 10–2 323.2 K), while pure lowest (1.051 10–5 298.2 K). "van't Hoff,...
Propolis is a resinous compound produced by honey bees. It contains bioactive molecules that possess wide range of biological functions. The chemical composition propolis affected various variables, including the vegetation, season, and area from which sample was collected. aim this study to analyze assess Cerana indica propoli’s antibacterial efficacy Kashmir region. Gas chromatography-mass spectrometry (GC-MS) analysis used determine Kashmiri propolis. A bacterial strains tested for...
Globally cancer and Alzheimer's disease (AD) are two major diseases still, there is no clearly defined molecular mechanism. There an opposite relation between AD which the proportion of emerging was importantly slower in patients, whereas slow patients with cancer. In cancer, regulation cell mechanisms interrupted by increase survival proliferation, while on contrary, related to augmented neuronal death, that may be either produced or associated amyloid-β (Aβ) tau deposition. Stated...
Microsphere based drug delivery system has gained substantial attention in the modern era. Microspheres are normally free-flowing powders that can be made with both natural and synthetic polymers. The sizes of microspheres ranges from 1 to 1000 µm. matrix systems which is uniformly dispersed, dissolved or suspended. contain solid liquid dispersed a system. current review provides an inclusive outline up date novel developments on formations have been reported increase bioavailability,...