A5043187917- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammation biomarkers and pathways
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
- Advanced Glycation End Products research
- Traditional Chinese Medicine Analysis
- Neurogenesis and neuroplasticity mechanisms
- Mitochondrial Function and Pathology
- Protease and Inhibitor Mechanisms
- Immune Response and Inflammation
- S100 Proteins and Annexins
- Neuroscience and Neuropharmacology Research
- Medicinal Plants and Bioactive Compounds
- Endoplasmic Reticulum Stress and Disease
- Signaling Pathways in Disease
Xi'an Jiaotong University
2019-2025
Abstract Background Glial activation and neuroinflammation play a crucial role in the pathogenesis development of Alzheimer’s disease (AD). The receptor for advanced glycation end products (RAGE)-mediated signaling pathway is related to amyloid beta (Aβ)-induced neuroinflammation. This study aimed investigate neuroprotective effects tanshinone IIA (tan IIA), natural product isolated from traditional Chinese herbal Salvia miltiorrhiza Bunge, against Aβ-induced neuroinflammation, cognitive...
Abstract Activation of glial cells and neuroinflammation play an important role in the onset development Alzheimer’s disease (AD). Triggering receptor expressed on myeloid 2 (TREM2) is a microglia-specific brain that involved regulating neuroinflammation. However, precise effects TREM2 neuroinflammatory responses its underlying molecular mechanisms AD have not been studied detail. Here, we employed lentiviral-mediated strategy to downregulation expression microglia APPswe/PS1dE9 (APP/PS1)...