A5092177577- Pain Mechanisms and Treatments
- Pain Management and Placebo Effect
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Myofascial pain diagnosis and treatment
- Hormonal and reproductive studies
- Lipid Membrane Structure and Behavior
- Peripheral Neuropathies and Disorders
- Olfactory and Sensory Function Studies
- Autoimmune Neurological Disorders and Treatments
- Urticaria and Related Conditions
- Sleep and Wakefulness Research
- Axon Guidance and Neuronal Signaling
- Neuroscience and Neuropharmacology Research
- Regulation of Appetite and Obesity
UCLouvain Saint-Louis Brussels
2023-2024
Saint Louis University
2023-2024
The prevalence of many pain conditions often differs between sexes. In addition to such quantitative distinctions, sexual dimorphism may also be qualitative reflecting differences in mechanisms that promote men and women. A major factor influences the likelihood perception is threshold for activation nociceptors. Peripheral nociceptor sensitization has been demonstrated clinically relevant conditions. Whether peripheral can occur a sexually dimorphic fashion, however, not extensively...
Abstract Paraneoplastic neurological syndromes arise from autoimmune reactions against nervous system antigens due to a maladaptive immune response peripheral cancer. Patients with small cell lung carcinoma or malignant thymoma can develop an the CV2/collapsin mediator protein 5 (CRMP5) antigen. For reasons that are not understood, approximately 80% of patients experience painful neuropathies. Here, we investigated mechanisms underlying anti-CV2/CRMP5 autoantibodies (CV2/CRMP5-Abs)-related...
Abstract The recent demonstration of differences in transcript expression human post-mortem sensory neurons suggests the possibility sexually dimorphic pain mechanisms. To date, however, concept “male” and “female” nociceptors has not been demonstrated at a functional level. We now report sensitization female, but male, by prolactin revealing female-selective mechanism that can be exploited to improve treatment women.
Abstract Cell membranes consist of heterogeneous lipid nanodomains that influence key cellular processes. Using FRET-based fluorescent assays and fluorescence lifetime imaging microscopy (FLIM), we find the dimension cholesterol-enriched ordered membrane domains (OMD) varies considerably, depending on specific cell types. Particularly, nociceptor dorsal root ganglion (DRG) neurons exhibit large OMDs. Disruption OMDs potentiated action potential firing in DRG facilitated opening native...
ABSTRACT Cell membranes consist of heterogeneous lipid nanodomains that influence key cellular processes. Using FRET-based fluorescent assays and fluorescence lifetime imaging microscopy (FLIM), we found the dimension cholesterol-enriched ordered membrane domains (OMD) varies considerably, depending on specific cell types. Particularly, nociceptor dorsal root ganglion (DRG) neurons exhibit large OMDs. Disruption OMDs potentiated action potential firing in DRG facilitated opening native...