A5009918144- Reproductive Biology and Fertility
- Ovarian function and disorders
- Electrospun Nanofibers in Biomedical Applications
- Sexual function and dysfunction studies
- Periodontal Regeneration and Treatments
- Sperm and Testicular Function
- Tissue Engineering and Regenerative Medicine
- Estrogen and related hormone effects
- Maternal and fetal healthcare
- Reproductive System and Pregnancy
- Reproductive Health and Contraception
Seoul National University
2021-2024
Seoul National University Bundang Hospital
2021-2024
Transplantation of ovary is one method facilitating fertility preservation to increase the quality life cancer survivors. Immediately after transplantation, ovaries are under ischemic conditions owing a lack vascular anastomosis between graft and host tissues. The transplanted can suffer damage because oxygen nutrients, resulting in necrosis dysfunction. In technique proposed this paper, encapsulated with nitric oxide-releasing nanoparticles (NO-NPs) fibrin hydrogels, which form carrying...
Hormone replacement therapy (HRT) has been a primary method in menopausal women and patients with ablated ovaries, but safety concern. Cell-based HRT emerged as an alternative approach without side effects causing pharmaceutical via 3-dimensionally engineered constructs layering ovarian hormone-producing cells. In this study, we applied micro-sized cell-laden hydrogel beads to cell-based using minimally invasive the rat model. Here, constructed GC/TC-laden microbeads (GTBs; GC, granulosa...
Objective A beneficial effect on endometrial thickness (EMT) and improvement of pregnancy outcome after intrauterine infusion platelet-rich plasma (PRP) has been suggested. This study assessed the PRP live birth rate obstetrical outcomes analyzed cytokines that can potentially improve through PRP. Method was a prospective cohort conducted in university hospital fertility center. The included ninety-one patients who had history two or more failed vitro fertilization (IVF) attempts refractory...
In women, menopause manifests with a variety of symptoms related to sex-hormone deficiency. Supplementing steroid hormones pharmacological drugs has been widely practiced. However, considering the possible complications associated artificial hormone therapy, studies have conducted find an alternative replacement therapy. Accordingly, this study aimed evaluate efficacy tissue-based therapy (tHRT) for treating post-menopausal signs and symptoms. CD-1 mice were ovariectomized, ovaries...
One of the emerging strategies in constructing artificial ovary is concern remaining malignant cells cryopreserved ovarian tissue, impeding fertility preservation after chemotherapy. The extracellular matrix an material tissue engineering due to contents obtained from "the tissue," easy-to-xenograft potential, and cost-effectiveness processes. We fabricated "injectable ovary" utilizing a xenogeneic (ECM) hydrogel bovine tissues. ECM hydrogel, through process decellularization, milling,...
As the most prominent and ideal modality in female fertility preservation, ovarian tissue cryopreservation, transplantation often confront challenge of ischemic damage follicular loss from avascular transplantation. To surmount this impediment, we engineered a novel platelet-derived factors-encapsulated fibrin hydrogel (PFH), paradigmatic biomaterial. PFH encapsulates autologous factors, utilizing physiological blood coagulation cascade for precise local delivery bioactive molecules. In our...