A5054907732- Alkaline Phosphatase Research Studies
- Biochemical and Molecular Research
- Biochemical and Structural Characterization
- Chemical Synthesis and Analysis
- Protein Hydrolysis and Bioactive Peptides
- Bladder and Urothelial Cancer Treatments
- Microbial Natural Products and Biosynthesis
- Gut microbiota and health
- Urinary Tract Infections Management
- Enzyme Structure and Function
- Parathyroid Disorders and Treatments
- Plant Stress Responses and Tolerance
- Curcumin's Biomedical Applications
- Plant Disease Management Techniques
- Biochemical effects in animals
- Cholinesterase and Neurodegenerative Diseases
- Antimicrobial Peptides and Activities
- Natural Antidiabetic Agents Studies
- Therapeutic Uses of Natural Elements
- Antimicrobial agents and applications
- Advancements in Transdermal Drug Delivery
- Machine Learning in Bioinformatics
- Proteins in Food Systems
- Porphyrin Metabolism and Disorders
- Phenothiazines and Benzothiazines Synthesis and Activities
University of Split
2008-2024
Recent findings suggest that human microbiome can influence the development of cancer, but role microorganisms in bladder cancer pathogenesis has not been explored yet. The aim this study was to characterize and compare urinary patients with those healthy controls. Bacterial communities present urine specimens collected from 12 male diagnosed 11 healthy, age-matched individuals were analysed using 16S sequencing. Our results show most abundant phylum both groups Firmicutes, followed by...
Exposure to environmental pollutants and human microbiome composition are important predisposition factors for tumour development
Curcumin is a natural compound found in turmeric that exhibits diverse biological activities. However, its poor bioavailability limits therapeutic application, which has led to the development of various bioavailability-improved formulations. In this methodological study, we analyzed whether systematic reviews on curcumin considered systemic oral formulations when synthesizing evidence from human clinical trials. A total 171 published between 2003 and 2022 were included study. From studies,...
SUMMARY Watermelon is a crop with high water demand and frequently grown under conditions of higher than normal root-zone salinity. In the present study, seedlings watermelon (cv. Fantasy, Citrullus lanatus (Thunb.) Matsum & Nakai ) were either ungrafted or grafted on three rootstocks: Strong Tosa, S1 (both Cucurbita maxima × moschata ), Emphasis ( Lagenaria siceraria ). All plants exposed to an NaCl-induced salinity stress (electrical conductivity, EC=2·2, 4·0, 6·0 dS/m). The vegetative...
The present study compares the gastrointestinal stability of rosmarinic acid in aqueous extracts thyme, winter savory and lemon balm with pure acid. was detected after two-phase vitro digestion process (gastric duodenal) human enzymes. concentration undigested digested samples using HPLC-DAD. Results showed that significantly higher than from plant both gastric intestinal phases digestion. Among extracts, most stable (14.10%) (6.5%). temperature (37 °C) slightly alkaline medium (pH=7.5) did...
It is unknown how randomized controlled trials (RCTs) approach the problem related to curcumin bioavailability. We analyzed methods and reporting regarding bioavailability of systemic oral used in RCTs. searched PubMed on 12 September 2020, find articles RCTs that as an intervention. extracted data about trial characteristics, products used, for improving bioavailability, mentions included 165 The most common category intervention was simply described "curcumin" or "curcuminoids" without a...
This study compares the oxidative stability of fat isolated from bovine, caprine, ovine and asinine milk as well antioxidant activity casein whey these milks. Fat bovine showed highest stability. The was examined before after an in vitro digestion process. Whey activity. increased simulated intestinal digestion. In addition, results this that exhibited radical scavenging comparable with strong synthetic antioxidants butylated hydroxyanisole ( BHA ) hydroxytoluene BHT ).
As the seventh most common human malignancy, bladder cancer represents a global health problem. In addition to well-recognized risk factors such as smoking and exposure chemicals, various infectious agents have been implicated cofactors in pathogenesis of urothelial malignancies. The aim present study was assess possible association viral infection Croatian patients. Biopsy specimens were collected from total 55 patients diagnosed with different stages cancer. Initial screening DNA extracts...
Abstract Olive trees ( Olea europaea L.) are considered moderately tolerant to salinity, with clear differences found among cultivars. One‐year‐old self‐rooted olive plants of the Croatian cv. Oblica and Italian Leccino were grown for 90 d in nutrient solutions containing 0, 66, or 166 mM NaCl, respectively. The shoot length number nodes leaves both cultivars not affected by salinity up 66 NaCl. However, at growth was reduced earlier a higher extent than Oblica. After 10 exposure increased...
Bemisia tabaci is one of the most devastating pests in tomato greenhouse production. Insecticide resistance management for B. requires a novel approach that maximizes nonchemical methods pest control. The aim this study was to test effects rootstocks on populations hydroponically grown plants. In order contribute better understanding mechanisms defining attractiveness plant aerial pest, leaf anatomy and amino acid composition phloem sap were assessed. A two-factorial experimental design...
Recent findings suggest that microorganisms inhabiting the human body can influence development of cancer, but role in bladder cancer pathogenesis has not been explored yet. The aim this study was to characterize and compare urinary microbiome patients with those healthy controls. Bacterial communities present urine specimens collected from male diagnosed primary or recurrent, non-muscle invasive cancers, healthy, age-matched individuals were analysed using 16S Illumina MiSeq sequencing. Our...
Abstract The adenylation (A) domain in nonribosomal peptide synthetases catalyses a two‐step reaction which an amino acid is activated and then transferred to the neighbouring thiolation (T) domain. In this study, we investigated role of conserved A9 core sequence A‐domain tyrocidine synthetase 1, by analysis single mutations region. Mutation absolutely proline (P490G) significantly reduced conformational stability protein, as evidenced increased susceptibility proteolytic cleavage...
Mutations, replacing amino acids involved in the formation of hydrogen bonds between subunits dimeric alkaline phosphatase, have been introduced.Influence mutations on kinetic properties and structural stability mutant enzymes was established.In addition, alterations protein dynamic studied using room temperature phosphorescence.Kinetic both were virtually same, differing from wild type enzyme k cat value that almost twice lower.Changes proteins, compared to enzyme, did not parallel changes...