A5061647842- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Health Systems, Economic Evaluations, Quality of Life
- Prostate Cancer Treatment and Research
- Inhalation and Respiratory Drug Delivery
- Preterm Birth and Chorioamnionitis
- Pharmaceutical studies and practices
- Economic and Financial Impacts of Cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Prostate Cancer Diagnosis and Treatment
- Diabetes Management and Education
- Chronic Disease Management Strategies
- Infant Development and Preterm Care
- Neonatal Respiratory Health Research
- Neurogenetic and Muscular Disorders Research
- Neuroblastoma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Statistical Methods in Clinical Trials
- Ocular Oncology and Treatments
- Erythrocyte Function and Pathophysiology
- IL-33, ST2, and ILC Pathways
- Reproductive Health and Technologies
- Primary Care and Health Outcomes
- Agricultural Economics and Practices
- Cardiovascular Issues in Pregnancy
Hemel Hempstead Hospital
2021
Health Economics and Outcomes Research (United Kingdom)
2016-2019
GlaxoSmithKline (United Kingdom)
2014-2016
Isle of Wight NHS Trust
2008
St. Mary’s Hospital
2008
Abstract Aims To assess the effectiveness and acceptability of peer advisers in diabetes delivering a programme training on self‐management for people with diabetes. Methods Adults were randomly allocated to an education delivered either by trained or specialist health professionals. The primary outcome measure was change knowledge tested before at conclusion four courses, each consisting six sessions. Glycated haemoglobin Diabetes Care Profile assessed baseline 6 months. Sessional...
Objective: Leuprolide is an established luteinizing hormone–releasing hormone (LHRH) agonist used as first-line treatment in advanced prostate cancer. As different formulations and dosing schedules are likely to have economic implications, we aimed evaluate their efficacy, safety, costs nine European countries: Austria, Belgium, Czech Republic, Hungary, Italy, Latvia, Netherlands, Poland, Portugal. Methods: Database searches identified 13 clinical trials of leuprolide 1- (1 M), 3- (3 M)...
Gonadotropin-releasing hormone-analog type, fertilization method, and number of embryos available for cryopreservation should be incorporated into economic evaluations highly purified human menopausal gonadotropin (HP-hMG) recombinant follicle-stimulating hormone (r-hFSH), as they may affect treatment costs. We searched randomized trials meta-analyses comparing HP-hMG r-hFSH. Meta-analysis showed no significant difference in live births (odds ratio 0.82, 95% confidence interval [CI]...
Fluticasone furoate (FF)/vilanterol (VI) is a once-daily inhaled corticosteroid (ICS)/long-acting beta2 agonist (LABA) combination. FF/VI, 92/22mcg and 184/22mcg, are approved in Europe as maintenance therapy persistent asthma. We report data from mixed treatment comparisons (MTC) of FF/VI against established twice-daily ICS/LABA combination therapies on clinical efficacy outcomes. Data 31 parallel-group randomised controlled trials (RCTs) ICS/LABA, ≥8 weeks' duration patients aged ≥12 years...
Abstract Background The evaluation of clinical evidence takes account health benefit (efficacy and safety) the degree certainty in estimate benefit. In orphan indications practical ethical challenges conducting trials, particularly paediatric patients, often limit available evidence, rendering structured challenging. While acknowledging paucity regulators reimbursement authorities compare efficacy safety alternative treatments for a given indication, context benefits other similar or...
Objective The objective of our study was to review the efficacy and safety atosiban nifedipine using both direct indirect evidence. Data sources We performed electronic (e.g. MEDLINE, EMBASE, CENTRAL) hand searches (last search August 2011) identify randomized controlled trials (RCTs) comparing with directly, or either drug betamimetics, in order allow for analyses. Methods selection A conducted published, unpublished, ongoing RCTs pregnant women under threat preterm labor. Tabulation,...
Применение 1-, 3- и 6-месячных лекарственных депо-форм лейпрорелина ацетата в гормональной терапии рака предстательной железы 9 европейских странах: обзор доказательств экономическая оценка.
639 Background: Trifluridine/tipiracil (FTD/TPI) is indicated and recommended for the treatment of previously treated metastatic colorectal cancer (mCRC). Previous evaluations used pooled clinical evidence from Phase III (RECOURSE) II trials to model cost-effectiveness, but FTD/TPI specific utilities were not available alternative data sources used. The aim this study was utilize EQ-5D an ongoing IIIb trial (PRECONNECT) within updated cost-effectiveness validate health-related quality life...