A5035228852- Mechanical Circulatory Support Devices
- Cardiovascular Health and Disease Prevention
- Fluid Dynamics and Heat Transfer
- Coronary Interventions and Diagnostics
- Particle Dynamics in Fluid Flows
- Fluid Dynamics and Turbulent Flows
- Rheology and Fluid Dynamics Studies
- Plant Surface Properties and Treatments
- Fluid Dynamics and Mixing
- Blood properties and coagulation
- Combustion and flame dynamics
- Central Venous Catheters and Hemodialysis
- Granular flow and fluidized beds
- Electrohydrodynamics and Fluid Dynamics
- Cardiac Arrest and Resuscitation
- Hydraulic and Pneumatic Systems
- Fluid Dynamics Simulations and Interactions
- Advanced Combustion Engine Technologies
- Fuel Cells and Related Materials
- Cardiovascular Function and Risk Factors
- Advanced Cellulose Research Studies
- Fluid Dynamics and Vibration Analysis
- Lattice Boltzmann Simulation Studies
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
KTH Royal Institute of Technology
2015-2025
Swedish e-Science Research Centre
2013-2022
Tekniska Högskolans Studentkår
2022
Wallenberg Wood Science Center
2016
Lund University
2006-2009
Abstract Cellulose nanofibrils can be obtained from trees and have considerable potential as a building block for biobased materials. In order to achieve good properties of these materials, the nanostructure must controlled. Here we present process combining hydrodynamic alignment with dispersion–gel transition that produces homogeneous smooth filaments low-concentration dispersion cellulose in water. The preferential fibril orientation along filament direction controlled by parameters....
Abstract Extracorporeal membrane oxygenation (ECMO) is used for rescue in severe respiratory and/or circulatory failure. The patient’s blood pumped over artificial surfaces the ECMO circuit. A platelet activation model was applied to study potential thrombogenicity of circuit components: centrifugal pump, cannulae, and tubing connectors. Based on accumulated effect scalar form stress acting time, enables assessment pinpoints regions elevated risk a component. Numerical simulations flow...
Abstract The mechanism underlying the association between elevated red cell distribution width (RDW) and poor prognosis in variety of diseases is unknown although many researchers consider RDW a marker inflammation. We hypothesized that directly affects intravascular hemodynamics, interactions circulating cells vessel wall, inducing local changes predisposing to atherothrombosis. applied different human animal models verify our hypothesis. Carotid plaques harvested from patients with high...
Complex, unsteady fluid flow phenomena in the arteries arise due to pulsations of heart that intermittently pumps blood extremities body. The many different waveform variations observed throughout arterial network are a result this process and function vessel properties. Large scale secondary structures generated aortic arch larger branches arteries. An experimental 180° curved artery test section with physiological inflow conditions was used validate computational methods implemented study....
Anatomic aortic anomalies are seen in many medical conditions and known to cause disturbances blood flow. Turner syndrome (TS) is a genetic disorder occurring only females where cardiovascular anomalies, particularly of the aorta, frequently encountered. In this study, numerical simulations applied investigate flow characteristics four TS patient- related arches (a normal geometry, dilatation, coarctation elongation transverse aorta). The Quemada viscosity model was account for non-Newtonian...
The use of extracorporeal life support devices such as membrane oxygenation in adults requires cannulation the patient's vessels with comparatively large diameter cannulae to allow circulation volumes blood (>5 L/min). cannula and length are major determinants for flow. Manufacturing companies present pressure-flow charts cannulae; however, these tests performed water. Aims this study were 1. investigate specified obtained when using human circulating medium 2. providers data correct choice...
Abstract Venovenous extracorporeal membrane oxygenation (ECMO) can be performed with two single lumen cannulas (SLCs) or one dual-lumen cannula (DLC) where low recirculation fraction ( $${R}_{f}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mi>R</mml:mi><mml:mi>f</mml:mi></mml:msub></mml:math> ) is a key performance criterion. DLCs are widely believed to have lower , though these not been directly compared. Similarly, correct positioning considered critical...
Alignment of anisotropic supermolecular building blocks is crucial to control the properties many novel materials. In this study, alignment process cellulose nanofibrils (CNFs) in a flow-focusing channel has been investigated using small-angle X-ray scattering (SAXS) and modeled Smoluchowski equation, which requires known flow field as input. This was experimentally microparticle-tracking velocimetry by numerically applying two-fluid level set method. A semidilute dispersion CNFs continuous...
Adequate extracorporeal membrane oxygenation support in the adult requires cannulae permitting blood flows up to 6-8 L/minute. In accordance with Poiseuille’s law, flow is proportional fourth power of cannula inner diameter and inversely its length. law can be applied obtain pressure drop an incompressible, Newtonian fluid (such as water) flowing a cylindrical tube. However, pseudoplastic non-Newtonian fluid, validity questionable for prediction properties clinical practice. Pressure–flow...
Abstract Introduction Extracorporeal membrane oxygenation is a lifesaving treatment for patients with refractory acute respiratory, circulatory, or combined cardiopulmonary failure. The patient cannulated one two cannulae drainage and reinfusion of blood. Blood drained from the patient, pumped through lung returned to patient. Treatment efficiency depends on correct cannula positioning interactions between cannula. Methods An experimental setup was built study isolated performance 24 Fr...
Extracorporeal membrane oxygenation is a life-saving therapy used in case of acute respiratory/circulatory failure. Exposure blood to non-physiological surfaces and high shear stresses related hemolytic damage platelet activation. A detailed knowledge the fluid dynamics components under different scenarios thus paramount assess thrombogenicity circuit.An investigation flow structures developing conventional lighthouse tip (single-staged) drainage cannula was performed with cross-validated...
Extracorporeal life support (ECLS) includes life-saving in severe acute cardiac and/or pulmonary failure. In the past 20 years, centrifugal pumps have become primary choice to deliver required blood flow. Pumps of various designs, with different approved operating ranges, are today available clinicians. The use low flow condition has been shown increase hemolytic and thrombogenic risks treatment. Further, operation associated retrograde at pump inlet. this study, experimental numerical...
Extracorporeal membrane oxygenation (ECMO) is a therapy used in severe cardiopulmonary failure. Blood pumped through an artificial circuit exposing it to nonphysiologic conditions, which promote platelet activation and coagulation. Centrifugal pumps at lower flow rates than their design point may lose pump efficiency increase the risk of hemolysis. In this study, thrombogenic properties two ECMO designed for adult neonatal use were evaluated using simulations different scenarios. Three...
Extracorporeal membrane oxygenation is a life-saving support therapy in the case of cardiopulmonary refractory failure. Its use associated to complications due presence artificial surfaces and supraphysiological stress conditions. Thus, knowledge fluid structures each component can give insight into sources blood damage. In this study, an experimentally validated numerical study conventional lighthouse tip cannula return configuration was carried out characterize flow using water or...
The purpose of this study is to assess the importance non-Newtonian rheological models on blood flow in human thoracic aorta.The pulsatile aorta simulated using Casson, Quemada and Walburn-Schneck addition a case fixed (Newtonian) viscosity. impact four (using constant hematocrit) was assessed with respect (i) magnitude deviation viscosity relative reference value (the Newtonian case); (ii) wall shear stress (WSS) its time derivative; (iii) common WSS-related indicators, OSI, TAWSS RRT; (iv)...
Blood clot formation can be initiated by local flow conditions where regions of high shear and long residence time regions, such as separation stagnation, have been identified risk factors. This study highlights coherent structures, some which not yet considered in the literature that may contribute to blood ECMO (Extra Corporeal Membrane Oxygenator) circuit. The centrifugal pump investigated this is compact delivers adequate volume with relatively pressure order compensate for large drop...
Surface roughness plays a key role in the clogging of dense suspensions.
Abstract Venovenous extracorporeal membrane oxygenation is a treatment for acute respiratory distress syndrome. Femoro-atrial cannulation means blood drained from the inferior vena cava and returned to superior cava; opposite termed atrio-femoral. Clinical data comparing these two methods scarce conflicting. Using computational fluid dynamics, we aim compare atrio-femoral femoro-atrial assess impact on recirculation fraction, under ideal conditions several clinical scenarios....