A5033241490- Erythropoietin and Anemia Treatment
- Hemoglobinopathies and Related Disorders
- Multiple Myeloma Research and Treatments
- Erythrocyte Function and Pathophysiology
- Monoclonal and Polyclonal Antibodies Research
- Atrial Fibrillation Management and Outcomes
- Drug Transport and Resistance Mechanisms
- Iron Metabolism and Disorders
- Chronic Lymphocytic Leukemia Research
- Peptidase Inhibition and Analysis
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Statistical Methods in Clinical Trials
- Blood properties and coagulation
- Biosimilars and Bioanalytical Methods
- Pharmacogenetics and Drug Metabolism
- Protein Degradation and Inhibitors
- Bacterial Genetics and Biotechnology
- Pharmacological Effects and Toxicity Studies
- Bacteriophages and microbial interactions
- Liver Disease Diagnosis and Treatment
- Escherichia coli research studies
- Antibiotics Pharmacokinetics and Efficacy
- Blood groups and transfusion
- Light effects on plants
Chinese University of Hong Kong
2019-2025
Xinyang Normal University
2025
Huzhou University
2024
North China University of Technology
2024
South China Agricultural University
2021-2024
Capital Normal University
2023
Taiyuan University of Technology
2023
Boston University
2023
Jilin University
2014-2023
Tufts University
2023
Objective To date, there are no studies regarding the lactylation profile and its role in critically ill patients. Thus, we aimed to examine expression of histone H3 lysine 18 (H3K18) patients with septic shock. Methods Thirteen healthy volunteers 35 from Department Surgical Intensive Care Medicine, Beijing Hospital were enrolled our study. Baseline information clinical outcomes obtained prospectively. Lactylation levels all proteins H3K18 peripheral blood mononuclear (PBMC) determined by...
Daratumumab is a CD38 monoclonal antibody recently approved for the treatment of multiple myeloma (MM). We report daratumumab pharmacokinetic data from GEN501, phase I/II dose-escalation (0.005–24 mg/kg) and dose-expansion (8 or 16 study, SIRIUS, II study mg/kg), in relapsed refractory MM. Noncompartmental analysis was conducted to characterize pharmacokinetics, and, both studies, exhibited nonlinear characteristics. Decreasing clearance with increasing dose suggests saturation...
New therapeutic strategies are urgently needed to improve clinical outcomes in patients with multiple myeloma (MM). Daratumumab is a first‐in‐class, CD38 human immunoglobulin G1κ monoclonal antibody approved for treatment of relapsed or refractory MM. Identification an appropriate dose regimen daratumumab challenging due its target‐mediated drug disposition, leading time‐ and concentration‐dependent pharmacokinetics. We describe thorough evaluation the recommended
Objective. To assess the efficacy and safety of JNJ-40346527, a selective inhibitor colony-stimulating factor-1 (CSF-1) receptor kinase that acts to inhibit macrophage survival, proliferation, differentiation in patients with active rheumatoid arthritis (RA) despite disease-modifying antirheumatic drug (DMARD) therapy. Methods. In this randomized, double-blind, placebo-controlled, parallel group study, adults were randomized (2:1) receive oral JNJ-40346527 100 mg or placebo twice daily...
The population pharmacokinetics (PK) of rivaroxaban have been evaluated in several population‐specific models. We developed an integrated PK model using pooled data from 4,918 patients 7 clinical trials across all approved indications. Effects gender, age, and weight on apparent clearance (CL/F) volume distribution (V/F), renal function, comedication CL/F, relative bioavailability as a function dose (F) were analyzed. Virtual subpopulations for exposure simulations defined by creatinine...
To enhance gas drainage in the soft and hard interbedded (SHI) coal seam, it's necessary to unload in-situ stress improve its migration performance. In this research, a directional hydraulic flushing (DHF) technology was carried out. The stress-unloading improvement mechanism analyzed though numerical simulation, systematic engineering tests were conducted verify effect. results show that of performance SHI seam is caused by combined effect seepage-improving diffusion-improving. After DHF,...
Objectives: Intravenous (IV) iron therapy has been used to treat deficiency anemia (IDA), but its quantitative relationship between the pharmacokinetics and biodistribution remains unclear. Understanding disposition in tissues is crucial for optimizing IV dosage management [1]. Here, we aim develop a whole-body mechanistic physiologically-based pharmacokinetic (PBPK) model investigate iron-distribution mice, extrapolate rats humans examine utility of predicting tissue across species.Methods:...
Objectives: Iron deficiency is associated with elevated platelet counts (PLT), through mechanisms that are poorly understood. Through in vitro study, we demonstrated iron influences erythropoiesis and thrombopoiesis by regulating hematopoietic stem progenitor cells (HSPCs) commitment towards the two lineages. Specifically, a high concentration of drives HSPCs into erythroid lineage, whereas low promotes megakaryocytic lineage. In this aim to 1) further investigate effect on vivo using rats...
Disulfides are commonly used as alternatives of thiols; however, the full utilization both S atoms disulfides under TM-, oxidant/reductant-free conditions is still challenging. In this study, an efficient synthesis thioethers from and quaternary ammonium salts has been developed. Both can be transformed into thioether products, thus improving sulfur resource utilization. The method easily extended to valuable alkyl dithiocarbamates readily scaled up gram scale, showing good practicality value.
Abstract Exposure to ultraviolet B radiation (UV-B) stress can have serious effects on the growth and development of plants. Germin-like proteins (GLPs) may be involved in different abiotic biotic responses plants, but little is known about role GLPs UV-B response acclimation In present study, knockout GLP 8–14 (OsGLP1) using CRISPR/Cas9 system resulted mutant rice (Oryza sativa L.) plants (herein called glp1) that exhibited UV-B-dependent formation lesion mimic leaves. Moreover, glp1 grown...
The aim of this study was to develop an integrated pharmacokinetic and pharmacodynamic (PK/PD) model assess the comparability between epoetin alfa HEXAL/Binocrit (HX575) a comparator by model-based approach. PK/PD data-including serum drug concentrations, reticulocyte counts, red blood cells, hemoglobin levels-were obtained from 2 clinical studies. In sum, 149 healthy men received multiple intravenous or subcutaneous doses HX575 (100 IU/kg) 3 times week for 4 weeks. A population based on...
To address the issues of Real-Time DEtection TRansformer (RT-DETR) object detection model, including poor defect feature extraction in task rail fastener detection, inefficient use computational resources, and suboptimal channel attention self-attention mechanism, following improvements were made. Firstly, a Super-Resolution Convolutional Module (SRConv) was designed as separate component integrated into Backbone network, which enhances image details clarity while preserving original...
The aim of this study was to understand the influence disease and patient characteristics on exposure daratumumab, an immunoglobulin Gκ (IgGκ) monoclonal antibody, clinical outcomes in relapsed or refractory multiple myeloma (MM). Baseline type, albumin levels, renal/hepatic function, age, sex, race, weight, Eastern Cooperative Oncology Group (ECOG) status, number prior therapies were evaluated using data from two studies—GEN501 (N = 104) SIRIUS 124). Daratumumab clearance approximately 110%...
Our previous study reported that erythroferrone (ERFE), a newly identified hormone produced by erythroblasts, responded to recombinant human erythropoietin (rHuEPO) sensitively but its dynamics was complicated double peaks and circadian rhythm. This intends elucidate the underlying mechanisms for of ERFE further determine whether early measurements can predict haemoglobin responses rHuEPO.