A5072155188- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Chronic Lymphocytic Leukemia Research
- Autoimmune and Inflammatory Disorders Research
- Polysaccharides and Plant Cell Walls
- Sarcoidosis and Beryllium Toxicity Research
- Schizophrenia research and treatment
- Polysaccharides Composition and Applications
- Bacteriophages and microbial interactions
- Biofuel production and bioconversion
- Mental Health and Psychiatry
- Catalysis for Biomass Conversion
- Nanoparticle-Based Drug Delivery
- Bone and Joint Diseases
- Pharmacological Effects of Natural Compounds
- Food composition and properties
- Microbial Metabolites in Food Biotechnology
- Psoriasis: Treatment and Pathogenesis
- Lignin and Wood Chemistry
- Health Systems, Economic Evaluations, Quality of Life
- Plant Gene Expression Analysis
- Proteins in Food Systems
- Scoliosis diagnosis and treatment
- Attention Deficit Hyperactivity Disorder
Shandong First Medical University
2019-2023
Weifang Medical University
2023
Beijing Forestry University
2019-2023
Linyi University
2023
Fujian University of Traditional Chinese Medicine
2022
Wuhan Polytechnic University
2022
Shandong Provincial QianFoShan Hospital
2019
Shandong University
2019
Janssen (United States)
2013-2016
Northwick Park Hospital
2012
Health-related quality of life in schizophrenia can be assessed by direct patient response or a rating based on structured interview. This study compares both types instruments using series five standards: (1) sensitivity to change over time, (2) treatment effect, (3) correlation with symptom severity, (4) global clinical ratings, and (5) other measures health-related life. Four hundred twenty-three inpatients participating trial comparing clozapine haloperidol (VA Cooperative Study Health...
<h3>Objective</h3> To evaluate golimumab9s effect on MRI-detected inflammation and structural damage in patients with active rheumatoid arthritis (RA) despite methotrexate (MTX). <h3>Methods</h3> Patients (n=444) were randomly assigned to placebo plus MTX, golimumab 100 mg placebo, 50 or MTX (subcutaneous injections every 4 weeks). A subset of 240 participated an MRI substudy. MRIs (1.5T+contrast enhancement) the dominant wrist metacarpophalangeal (MCP) joints obtained at baseline weeks 12...
Introduction: Herein, a hyaluronic acid (HA)-coated redox-sensitive chitosan-based nanoparticle, HA(HECS-ss-OA)/GA, was successfully developed for tumor-specific intracellular rapid delivery of gambogic (GA). Materials and methods: The polymer, HECS-ss-OA, prepared through well-controlled synthesis procedure with satisfactory reproducibility stable resulted surface properties the assembled cationic micelles. GA solubilized into inner core HECS-ss-OA micelles, while HA employed to coat...
This study compared the time course to clinical improvement with clozapine and conventional antipsychotic medications. A double-blind trial haloperidol in patients schizophrenia who were refractory medication hospitalized for 30 364 days at 15 Veteran Affairs medical centers during year before entry. Patients original randomly assigned or followed 12 months, maximum tolerable doses. completed a full of treatment (n=122), either another (n=123) also 9- 12-month assessment included. Response...
<h3>Objectives</h3> Evaluate relationships between MRI and clinical/laboratory/radiographic findings in rheumatoid arthritis (RA). <h3>Methods</h3> 637 methotrexate-naive patients (GO-BEFORE) 444 with active RA despite methotrexate (GO-FORWARD) were randomly assigned to subcutaneous placebo + methotrexate, golimumab 100mg placebo, 50mg or every-4-weeks. In GO-BEFORE(n=318) GO-FORWARD(n=240) substudies, of dominant wrist/metacarpophalangeal joints scored for synovitis, bone oedema erosion (RA...
Egg-white protein has an abundance of hydrophobic amino acids and could be a potential emulsifier after modification. Here, egg-white was modified via ultrasonic transglutaminase treatments to destroy the globular structure. The gel particles (EWP-GPs) were prepared then novel highly stable EWP-chitosan double-layer emulsion constructed. When treatment applied at 240 W TGase (20 U/g EWP) treatment, EWP-GPs had low particle size good emulsification performance. minimum 287 nm, polymer...
This study aimed to produce manno-oligosaccharides (MOS) from Gleditsia microphylla galactomannans (GMG) using CO2 and solid acid (Amberlyst-35) in subcritical water. The optimal condition for MOS preparation was 3 MPa CO2, 0.1 g/g (relative GMG) at 150 °C 40 min. maximum yield with a degree of polymerization 2 4 (M2-M4) 52.19%, which doubled the compared either solely or acid. Solid showed excellent performance producing under H2O–CO2 condition, due enhanced mass transfer efficiency...
Background: Although GCA is responsive to glucocorticoids (GCS), therapy causes significant toxicity and often fails induce sustained remission. Purpose: Assess safety efficacy of infliximab (IFX) in patients (pts) with new onset a randomized, double-blind, placebo-controlled, multi-center, Phase II study. Methods:Eligibility: diagnosis (ACR criteria); ≤4 weeks (wks) duration; resolution features normal ESR following treatment 40–60 mg prednisone or prednisolone/day; remission for 1 wk prior...