A5080855594- Microbial Natural Products and Biosynthesis
- Biochemical and Molecular Research
- Enzyme Structure and Function
- Carbohydrate Chemistry and Synthesis
- Fluorine in Organic Chemistry
- Marine Sponges and Natural Products
- Genomics and Phylogenetic Studies
- Chemical Synthesis and Analysis
- Amino Acid Enzymes and Metabolism
- Cancer, Hypoxia, and Metabolism
- Synthetic Organic Chemistry Methods
- Plant biochemistry and biosynthesis
- Plant-Microbe Interactions and Immunity
- Nanoplatforms for cancer theranostics
- Particle Accelerators and Free-Electron Lasers
- Synthesis and Biological Activity
- Alkaloids: synthesis and pharmacology
- Medical Imaging Techniques and Applications
- Laser Design and Applications
- Metabolomics and Mass Spectrometry Studies
- Fungal Biology and Applications
- Potato Plant Research
- Microbial Community Ecology and Physiology
- Luminescence and Fluorescent Materials
- Advanced X-ray Imaging Techniques
University of Aberdeen
2016-2025
Sichuan University
2001-2024
University of Glasgow
2009-2024
Marine Scotland
2021
State Key Laboratory of Oncogene and Related Genes
2019
Shanghai Jiao Tong University
2019
South China University of Technology
2017-2018
Wuhan University
2014-2015
University of St Andrews
2003-2014
Sunny BioDiscovery (United States)
2014
Abstract NIR-II fluorophores have shown great promise for biomedical applications with superior in vivo optical properties. To date, few small-molecule been discovered donor-acceptor-donor (D-A-D) or symmetrical structures, and upconversion-mitochondria-targeted dyes not reported. Herein, we report development of D-A type thiopyrylium-based frequency upconversion luminescence (FUCL) at ~580 nm upon excitation ~850 nm. H4-PEG-PT can only quickly effectively image mitochondria live fixed...
Novel NIR-II organic fluorophores were designed and synthesized using an AIE highly twisted donor–acceptor distortion strategy for bio-imaging beyond 1550 nm.
The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on culture media used for its growth. application an OSMAC approach this using a range cultivation resulted in isolation and identification three new compounds rare class 22-membered macrolactone polyketides, named chaxalactins A–C (1–3). In addition, known deferroxamine E (4), hygromycin A (5), 5″-dihydrohygromycin (6) were detected. characterized by NMR spectroscopy...
Streptomyces sp. strain C34, isolated from soil collected in the Chilean hyper-arid Atacama Desert, was cultured on different media, resulting isolation and identification of four new ansamycin-type polyketides. The organism selected for chemical investigation basis a genome-mining PCR-based experiment targeting gene encoding rifamycin-specific 3-amino-5-hydroxybenzoic acid synthetase (AHBA). compounds were structurally characterized using NMR MS techniques named chaxamycins A–D (1–4)....
Abstract The fluorinase is an enzyme that catalyses the combination of S ‐adenosyl‐ L ‐methionine (SAM) and a fluoride ion to generate 5′‐fluorodeoxy adenosine (FDA) through nucleophilic substitution reaction with as nucleophile. It only native fluorination has been characterised. was isolated in 2002 from Streptomyces cattleya , and, date, this source enzyme. Herein, we report three new isolates have identified by genome mining. novel fluorinases sp. MA37, Nocardia brasiliensis Actinoplanes...
Lasso peptides are ribosomally synthesized and post-translationally modified (RiPPs) that possess a unique "lariat knot" structural motif. Genome mining-targeted discovery of new natural products from microbes obtained extreme environments has led to the identification gene cluster directing biosynthesis lasso peptide, designated as chaxapeptin 1, in genome Streptomyces leeuwenhoekii strain C58 isolated Atacama Desert. Subsequently, 1 was characterized using high-resolution electrospray...
The clinical success of cisplatin ushered in a new era the application metallodrugs. When it comes to practice, however, drug resistance, tumor recurrence, and systemic toxicity make implausible completely heal patients. Herein, we successfully transform an electron acceptor [1, 2, 5]thiadiazolo[3,4-g]quinoxaline into novel second near-infrared (NIR-II) fluorophore H7. After PEGylation chelation, HL-PEG2k exhibits wavelength bathochromic shift, enhanced photothermal conversion efficiency...
Nanocarriers hold great promise for the controlled release of therapeutic payloads to target organs/tissues and extended duration anticancer agents in bloodstream. However, limited data on their vivo pharmacokinetics delivery process hamper clinical applications. Here we report a series micellar nanocarriers self-assembled from new-generation thiophenthiadiazole (TTD)-based NIR-II fluorophores HLAnP (n = 1-4) simultaneous bioimaging drug delivery. The HLA4P nanocarrier displays exceptional...
Choices choices: The fluorinase enzyme from Streptomyces cattleya (catalyzes the formation of a CF bond fluoride ions) also has capacity to utilize chloride ion although it clear preference for ion. mediates nucleophilic chlorination reaction, which is an unusual mechanism enzymatic chlorination. Supporting information this article available on WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z503582_s.pdf or author. Please note: publisher not responsible content functionality any...
The fluorinase enzyme from S. cattleya is applied as a catalyst for the efficient incorporation of [18F]-fluoride into [18F]-5'-fluoro-5'-deoxyadenosine, [18F]-5'-fluoro-5'-deoxyinosine and [18F]-5-fluoro-5-deoxyribose positron emission tomography (PET) applications.
Driven by increasing demand for the monitoring of industrial perfluorinated compounds (PFCs), identification novel fluorine containing (FOCs) and tracking organofluorine drugs their degradation products, there is a clear need sensitive, fluorine-specific detection unknown FOCs. Here we report first ever direct (speciation) method; capable individually detecting untargeted FOCs in environmental biological samples through application continuum source molecular absorption spectrometry (CS-MAS)...
Abstract Pyrrolizidine alkaloids (PAs) are a group of natural products with important biological activities. The discovery and characterization the multifunctional FAD‐dependent enzyme LgnC is now described. shown to convert indolizidine intermediates into pyrrolizidines through an unusual ring expansion/contraction mechanism, catalyze biosynthesis new bacterial PAs, so‐called legonmycins. By genome‐driven analysis, heterologous expression, gene inactivation, legonmycins were also originate...
(2<italic>R</italic>3<italic>S</italic>4<italic>S</italic>)-5-Fluoro-2,3,4-trihydroxypentanoic acid (5-FHPA) has been discovered as a new fluorometabolite in the soil bacterium <italic>Streptomyces</italic> sp. MA37.
<italic>Streptomyces xinghaiensis</italic> is the first fluorometabolite producing microorganism identified from marine environment.
A new actinomycete strain Micromonospora sp. K310 was isolated from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of two compounds fermentation culture. One is butremycin (2) which (3-hydroxyl) derivative known Streptomyces metabolite ikarugamycin (1) and other compound a protonated aromatic tautomer 5′-methylthioinosine (MTI) (3). Both were characterized by 1D, 2D NMR MS data. Butremycin displayed weak antibacterial activity against Gram-positive...