A5105294990- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Retinal Development and Disorders
- Systemic Lupus Erythematosus Research
- Corneal surgery and disorders
- interferon and immune responses
- Retinal Imaging and Analysis
- Psoriasis: Treatment and Pathogenesis
- Ophthalmology and Visual Impairment Studies
- MicroRNA in disease regulation
- Retinal and Macular Surgery
- Ophthalmology and Eye Disorders
- Cytokine Signaling Pathways and Interactions
- S100 Proteins and Annexins
- Abdominal Trauma and Injuries
- Intraocular Surgery and Lenses
- Liver Disease Diagnosis and Treatment
- Retinopathy of Prematurity Studies
- Corneal Surgery and Treatments
- Chromatography in Natural Products
- Fungal Biology and Applications
- Cerebral Venous Sinus Thrombosis
- Polysaccharides and Plant Cell Walls
- Neurological Disorders and Treatments
Shandong University of Traditional Chinese Medicine
2019-2025
Hunan University
2024
First Affiliated Hospital of Wannan Medical College
2024
Linyi People's Hospital
2020-2023
Sun Yat-sen University
2008-2013
University of Alabama at Birmingham
2013
Second Affiliated Hospital of Chengdu University of Traditional Chinese
2008
Northwestern University
2008
Modulating the behaviors of reactive astrocytes is a potential therapeutic strategy for neurodegenerative diseases. We found that upregulation and activation epidermal growth factor receptor (EGFR) occur in after different injuries optic nerves vivo . Activation EGFR regulates genes cellular processes representing most major markers related with glaucomatous neuropathy other neural disorders. These results suggest common, regulatory pathway triggers quiescent into response to nerve, perhaps...
BackgroundAlthough the statement that age is greatest risk factor for Age-related macular degeneration (AMD) widely accepted, cellular and molecular explanations clinical are not generally known. A major focus of AMD research retinal pigment epithelium (RPE)/choroid. The purpose this study was to characterize changes in RPE/choroid with may provide a background development AMD.Methodology/Principal FindingsWe compared transcriptional profiles, key protein levels histology from young old...
purpose. To assess the heritability of central corneal thickness (CCT) in Chinese children a classic twin study. methods. Twins aged 8 to 16 years were recruited from Guangzhou Twin Registry. Pachymetry data obtained by one operator using same imaging system. Zygosity was confirmed genotyping with polymorphic markers all same-sex pairs. The CCT right eyes chosen as trait interest analysis. Heritability assessed general sex-limitation model, Mx software (University Richmond, Virginia)....
Abstract Epidermal growth factor receptor (EGFR) is expressed in reactive astrocytes following injury the CNS. However, effects of activation EGFR pathway are not well established. In present study, we demonstrate that causes optic nerve astrocytes, as brain to form cribriform structures with cavernous spaces. Formation dependent on new protein synthesis and cell proliferation. Platelet‐derived basic fibroblast were effective. Smooth muscle cells epithelial do response activation. The...
Abstract Background Uveitis is a common recurrent autoimmune disease that seriously endangers the visual health of patients. MicroRNAs (miRNAs) are closely related to series diseases. Methods The present study aimed investigate effect miR-30b-5p on experimental uveitis (EAU) and its role in Notch signal activation as well T helper (Th) cell differentiation, relationship between levels activation, Th differentiation was further explored through flow cytometry, Immunohistochemistry...
purpose. To assess the heritability of disc area (DA), cup (CA), and cup–disc ratio (CDAR) as intermediate phenotypes for glaucoma in Chinese subjects a classic twin study. methods. Twins (n = 1160) aged 7 to 15 years were identified Guangzhou Twin Registry. Optic parameters measured with Heidelberg Retina Tomograph (HRT; Engineering GmbH, Heidelberg, Germany) by same examiner grader. Zygosity was confirmed genotyping 16 polymorphic markers all same-sex pairs. The DA, CA, CDAR right eyes...
This study aimed to investigate the dynamic effects of traditional Chinese medicine compound Longdan Xiegan Decoction (LXD) on inhibition Notch signaling pathway activation and T helper (Th) cell differentiation in rats with experimental autoimmune uveitis (EAU). Based a network pharmacology strategy, we conducted protein interaction analysis construct an active ingredient-disease treatment network. Gene Ontology (GO) enrichment Kyoto Encyclopedia Genes Genomes (KEGG) analyses were further...
Background Different diagnostic and grading systems of conjunctivochalasis have resulted in apparent disparity between the prevalence rates recent population-based studies. This study aimed to investigate 4-level system cited from Meller Tseng 1998 (abbreviated here as Meller's system) 5-level modified Zhang associates Zhang's regarding diagnosis patients' preferences for treatment general population. Methods A total 546 senile residents living Guiyangyuan community Shanghai, China,...
To investigate the safety of pancreatic body suspension (PBS) technique in laparoscopic splenectomy combined with pericardial devascularization for patients. A retrospective study inclusive 16 patients who underwent from 2017 to 2022 was performed. total 5 PBS and 11 traditional technique. There no significant difference age, sex, mass index (BMI), preoperative serum white cell count (WBC), platelets (PLT), hemoglobin (HB), albumin (ALB), prothrombin time (PT), bilirubin (TBIL), or spleen...
Objective To evaluate the agreement for ocular biological measurements obtained from Lenstar and IOL Master.Methods Patients who participated in our Guangzhou Twin Study follow-up examination June 2011 to August were enrolled.All subjects underwent LS 900,IOL Master,slit lamp fundus examinations.The data of right eye analyzed.The differences axial length (AL),anterior chamber depth (AD),radius (R) white-to-white distance (WTW) between two devices analyzed with t-test.The correlation was...
Background Normal adult optic disc rim width follows inferior ≥ superior nasal temporal (ISNT) rule.Analysis of the structural parameters with Heidelberg retina tomograph (HRT) can understand whether ISNT principle is suitable to other structure parameters.Objective This study was investigate characteristics nerve head in normal Chinese adults.Methods The parents twins who participated Guangzhou Twin Eye Study were enrolled Zhongshan Ophthalmic Center from 2006 June 2011 August.All subjects...
Background Heidelberg Retinal Tomograph (HRT) has been widely used in clinical diagnosis of glaucomatous optic neuropathy,importantly,the measurement results HRT may be affected by myopia.Therefore,studying the effect different refractive status and axial length on structural parameters disc is important.Objective This study was to evaluate influence error nerve head parameter measured HRT.Methods The parents who participate Guangzhou Twin Study were enrolled this investigation from July...
Background: Uveitis is a common recurrent autoimmune disease and MicroRNAs (miRNAs) can negatively regulate the expression of target genes by RNA interference. miRNAs are confirmed to be closely related diseases. However, effect miR-30b-5p on Notch signaling in experimental uveitis (EAU) unidentified.Methods: The role mir-30b-5p was analyzed bioinformatics, relationship between activation as well T helper cell differentiation EAU rats further explored both vivo vitro.Findings: ocular...