A5042410424- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Immune Response and Inflammation
- RNA and protein synthesis mechanisms
- NF-κB Signaling Pathways
- Inflammasome and immune disorders
- Cancer Immunotherapy and Biomarkers
Czech Academy of Sciences, Institute of Molecular Genetics
2020-2024
Charles University
2023-2024
Institute of Molecular Genetics
2022-2023
Abstract The kinase LCK and CD4/CD8 co-receptors are crucial components of the T cell antigen receptor (TCR) signaling machinery, leading to key fate decisions. Despite decades research, roles CD4–LCK CD8–LCK interactions in TCR triggering vivo remain unknown. In this study, we created animal models expressing endogenous levels modified resolve whether how co-receptor-bound drives signaling. We demonstrated that role depends on co-receptor which it is bound. CD8-bound largely dispensable for...
Regulatory T cells (Tregs) are indispensable for maintaining self-tolerance by suppressing conventional cells. On the other hand, Tregs promote tumor growth inhibiting anti-cancer immunity. In this study, we identified that increase quorum of self-reactive CD8 + required induction experimental autoimmune diabetes in mice. Their major suppression mechanism is limiting available IL-2, an essential T-cell cytokine. Specifically, inhibit formation a previously uncharacterized subset...
Article21 July 2020Open Access Source DataTransparent process Systematic analysis of the IL-17 receptor signalosome reveals a robust regulatory feedback loop Helena Draberova Laboratory Immunity & Cell Communication, BIOCEV, First Faculty Medicine, Charles University, Vestec, Czech Republic Adaptive Immunity, Institute Molecular Genetics Academy Sciences, Prague, Search for more papers by this author Sarka Janusova Daniela Knizkova Tereza Semberova Michaela Pribikova Andrea Ujevic Karel...
Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, relative differences self-reactivity among individual T-cell clones were appreciated as important factors regulating their fate and immune response, but role of biology is incompletely understood. We addressed diversity by generating an atlas mouse peripheral CD8+ cells, which revealed two unconventional populations antigen-inexperienced cells. In next step, we examined...
Abstract T cells are pivotal in the adaptive immune defense, necessitating a delicate balance between robust response against infections and self-tolerance. Their activation involves intricate cross-talk among signaling pathways triggered by T-cell antigen receptors (TCR) co-stimulatory or inhibitory receptors. The molecular regulation of these complex networks is still incompletely understood. Here, we identify adaptor protein ABIN1 as component complexes GITR OX40 co-stimulation lacking...
Linker for activation of T cells (LAT) plays a key role in T-cell antigenic signaling mammals. Accordingly, LAT orthologues were identified the majority vertebrates. However, not most birds. In this study, we show that gene is present genomes multiple extant It was properly assembled previously because its GC-rich content. expression enriched lymphoid organs chicken. The analysis coding sequences revealed strong conservation motifs between chicken and human. Overall, our data indicate...
Abstract Regulatory T cells (Tregs) are indispensable for maintaining self-tolerance by suppressing conventional cells. On the other hand, Tregs promote tumor growth inhibiting anti-cancer immunity. In this study, we identified that increase quorum of self-reactive CD8 + required induction experimental autoimmune diabetes. Their major suppression mechanism is limiting available IL-2, an essential T-cell cytokine. Specifically, inhibit formation a previously uncharacterized subset...
Abstract T cells are pivotal in the adaptive immune defense, necessitating a delicate balance between robust response against infections and self-tolerance. Their activation involves intricate cross-talk among signaling pathways triggered by T-cell antigen receptors (TCR) co-stimulatory or inhibitory receptors. The molecular regulation of these complex networks is still incompletely understood. We identified an adaptor protein, ABIN1 as component complexes GITR OX40 co-stimulation lacking...