A5011057158- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Neurogenesis and neuroplasticity mechanisms
- Immunotherapy and Immune Responses
- Parkinson's Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Blood disorders and treatments
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Dysphagia Assessment and Management
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Whipple's Disease and Interleukins
- Chronic Lymphocytic Leukemia Research
- Cell Adhesion Molecules Research
- SARS-CoV-2 and COVID-19 Research
- Eating Disorders and Behaviors
- Helicobacter pylori-related gastroenterology studies
- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- Long-Term Effects of COVID-19
- CAR-T cell therapy research
- Stress Responses and Cortisol
- Reproductive System and Pregnancy
King's College Hospital NHS Foundation Trust
2007-2024
Jigjiga University
2024
Ain Shams University
2005-2024
Abbott (Sweden)
2024
Ayub Medical College
2024
King's College Hospital
2009-2023
King's College London
2008-2023
Kings Health Partners
2012-2023
Guy's Hospital
2016
St Thomas' Hospital
1995-2015
Improved understanding and management of COVID-19, a potentially life-threatening disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward this end, we have identified core peripheral blood immune signature across 63 hospital-treated patients with COVID-19 who were otherwise highly heterogeneous. The includes discrete changes in B myelomonocytic cell composition, profoundly altered T phenotypes, selective cytokine/chemokine upregulation SARS-CoV-2-specific...
BackgroundActivated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in PIK3CD, the gene encoding catalytic subunit of (PI3Kδ).ObjectiveWe sought to review clinical, immunologic, histopathologic, and radiologic features APDS large genetically defined international cohort.MethodsWe applied clinical questionnaire performed medical notes, radiology, histopathology, laboratory investigations 53 patients with...
Regulatory T cell (Treg) therapy using recipient-derived Tregs expanded ex vivo is currently being investigated clinically by us and others as a means of reducing allograft rejection following organ transplantation. Data from animal models has demonstrated that adoptive transfer allospecific offers greater protection graft compared to polyclonal Tregs. Chimeric antigen receptors (CAR) are translatable synthetic fusion proteins can redirect the specificity cells toward designated antigens. We...
Background: Rituximab, a chimeric monoclonal antibody against CD20, is increasingly used in the treatment of B-cell lymphomas and autoimmune conditions. Transient peripheral depletion expected following rituximab therapy. Although initial clinical trials did not show significant hypogammaglobulinaemia, reports this are now appearing literature. Methods: We performed retrospective review patients previously treated with that were referred to Clinical Immunology symptomatic or severe...
Abstract Oligodendrocytes were studied in the anterior medullary velum (AMV) of rat using monoclonal antibody Rip, an oligodendrocyte marker unknown function. Confocal microscopic imaging double immunofluorescent labelling with antibodies to Rip and carbonic anhydrase II (CAII) revealed two biochemically morphologically distinct populations which either + CAII or CAII−. Double myelin basic protein (MBP) glial fibrillary acidic (GFAP) provided direct evidence that Rip‐labelled cells...
A Correction to this paper has been published: https://doi.org/10.1038/s41591-020-01186-5
Abstract Person-to-person transmission of SARS-CoV-2 virus has triggered a global emergency because its potential to cause life-threatening Covid-19 disease. By comparison paucisymptomatic clearance by most individuals, been proposed reflect insufficient and/or pathologically exaggerated immune responses. Here we identify consensus peripheral blood signature across 63 hospital-treated patients who were otherwise highly heterogeneous. The core conspicuously blended adaptive B cell responses...
Initiation of T-lymphocyte-mediated immune responses involves two cellular processes: entry into the cell cycle (G0→G1) for clonal proliferation and coordinated changes in surface secreted molecules that mediate effector functions. However, a point during G0→G1 beyond which T cells are committed to enter has not been defined. We define here commitment occurs 3 5 h after CD3 CD28 stimulation human CD4 or CD8 cells. Transition through this requires cdk6/4-cyclin D, since inhibition with...
Abstract Background: We examine the effect of eradicating Helicobacter in idiopathic parkinsonism (IP). Marked deterioration, where eradication‐therapy failed, prompted an interim report first 20 probands to reach de‐blinding. The null‐hypothesis, “eradication has no on principal outcome, mean stride length at free‐walking speed,” was rejected. study completion all 30 who had commenced post‐treatment assessments. Methods: This is a randomized, placebo‐controlled, parallel‐group efficacy...
Summary Splenectomy has been used in patients with common variable immunodeficiency disorders (CVID), mainly the context of refractory autoimmune cytopenia and suspected lymphoma, but there are understandable concerns about potential compounding an existing immunodeficiency. With increasing use rituximab as alternative treatment for cytopenia, role splenectomy CVID needs to be re-examined. This retrospective study provides largest cohesive data set date describing outcome 45 past 40 years....
Following Helicobacter pylori eradication in idiopathic parkinsonism (IP), hypokinesia improved but flexor-rigidity increased. Small intestinal bacterial-overgrowth (SIBO) is a candidate driver of the rigidity: hydrogen-breath-test-positivity common IP and case histories suggest that keeps SIBO at bay. In surveillance study, we explore relationships IP-facets to peripheral immune/inflammatory-activation, light presence/absence infection (urea-breath- and/or stool-antigen-test: positivity...
ABSTRACT Background Gut‐brain axis is widely implicated in the pathophysiology of Parkinson's disease (PD). We take an integrated approach to considering gut as a target for disease‐modifying intervention, using continuous measurements facets irrespective diagnostic divide. Methods characterised 77 participants with diagnosed‐PD, 113 without, by dietary/exogenous substance intake, faecal metabolome, intestinal inflammation, serum cytokines/chemokines, clinical phenotype including colonic...
Objectives: The objectives of the study were to assess knowledge regarding neonatal jaundice (NNJ) among students in school Midwifery Lafia, North Central Nigeria and find statistical significance association between their level score NNJ with selected sociodemographic variables. Material Methods: research design used for was a descriptive survey design, purposive sampling technique select 50 Nigeria. This prospective conducted within 11 months (from January November 2022). Data collected...