A5077865061- Genetics, Aging, and Longevity in Model Organisms
- Corneal Surgery and Treatments
- Histone Deacetylase Inhibitors Research
- Corneal surgery and disorders
- Neuroblastoma Research and Treatments
- Epigenetics and DNA Methylation
- Ocular Disorders and Treatments
- Diet and metabolism studies
- Prion Diseases and Protein Misfolding
- Birth, Development, and Health
- Ovarian cancer diagnosis and treatment
- Vitamin D Research Studies
- Ocular Surface and Contact Lens
- Neuroendocrine Tumor Research Advances
- Cell Adhesion Molecules Research
- Lung Cancer Research Studies
University of Helsinki
2015-2024
Folate receptor (FR) alpha (FOLR1) and beta (FOLR2) are membrane-anchored folate transporters that expressed at low levels in normal tissues, while their expression is strongly increased several cancers. Intriguingly, although the function of these receptors in, for example, development cancer has been studied intensively, role aging still unknown. To address this, we utilized Caenorhabditis elegans, which FOLR-1 sole ortholog receptors. We found loss does not affect reproduction, physical...
Abstract The outermost layer of the eye, cornea, is renewed continuously throughout life. Stem cells corneal epithelium reside in limbus at periphery and ensure homeostasis central epithelium. However, young mice, relies on located basal Here, we first studied growth during transition from newborn to adult assessed Keratin 19 (Krt19) expression as a hallmark maturation. Next, set out identify novel marker murine epithelial progenitor before, after maturation, found that Bmi1 expressed cornea...
Abstract Folate receptor (FR) alpha and beta (FRα FRβ) are membrane-anchored transporters that mediate folate uptake through endocytosis. Unlike other transporters, FRs expressed at low levels in normal tissues, while their expression is strongly increased several cancers. In addition to its canonical role transport, FRα, the most studied FR, also regulates signaling pathways unrelated folate- or one-carbon metabolism. Nevertheless, it not known how loss of receptors, overexpression, affects...
Histone H3/H4 chaperone anti-silencing function 1 (ASF1) is a conserved factor mediating nucleosomal assembly and disassembly, playing crucial roles in processes such as replication, transcription, DNA repair. Nevertheless, its involvement aging has remained unclear. Here, we utilized the model organism Caenorhabditis elegans to demonstrate that loss of UNC-85, homolog ASF1, leads shortened lifespan multicellular organism. Furthermore, show UNC-85 required for epigenome-mediated longevity,...
Abstract Small intestinal neuroendocrine tumors (SI-NETs) originating from the enterochromaffin cells of mucosa are among most common in small intestine. In past few decades incidence SI-NETs has increased more than four-fold Western countries. Although usually well differentiated and indolent with low mitotic activity, multiple discontinuous present up to 1/3 patients metastases found majority at diagnosis. Previous studies have described significantly elevated risk for gastrointestinal...