A5101727845- Hepatitis B Virus Studies
- Hepatitis C virus research
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Cell death mechanisms and regulation
- Cytokine Signaling Pathways and Interactions
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Lung Cancer Research Studies
- Sperm and Testicular Function
- Nanoparticles: synthesis and applications
- Cervical Cancer and HPV Research
- Laser-Ablation Synthesis of Nanoparticles
- Bioactive Compounds and Antitumor Agents
- Immunotherapy and Immune Responses
- Radiopharmaceutical Chemistry and Applications
- Mechanisms of cancer metastasis
- Liver Disease Diagnosis and Treatment
- Reproductive Biology and Fertility
- Eosinophilic Esophagitis
- Cancer therapeutics and mechanisms
- Reproductive System and Pregnancy
- Helicobacter pylori-related gastroenterology studies
Tabriz University of Medical Sciences
2018-2024
Urmia University
2024
Urmia University of Medical Sciences
2024
University of Tabriz
2024
Lorestan University of Medical Sciences
2022
Zanjan University of Medical Sciences
2022
Tarbiat Modares University
2022
Tehran University of Medical Sciences
2011-2018
Adjuvant therapy with novel and effective component has been presented as a contrivance in breast cancer treatment versus the conventional methods. The current research was done to evaluate implement of stattic, specific STAT3 inhibitor on anti-proliferative apoptotic behavior doxorubicin ZR-75-1 cells. Cell viability investigated by MTT assay, percentage apoptosis DAPI staining, Annexin V. Real Time-PCR applied find out correlation between mechanistic roles pathway signal modulation Bcl-2...
Summary Mutations within the coding region of hepatitis B surface antigen ( HB s A g) have been found naturally in chronic carriers. To characterize mutations g from Iranian carriers who were vaccine and/or medication naive. The genes 360 patients amplified and directly sequenced. distribution amino acid substitutions was classified according to different immune epitopes protein. All isolates belonged genotype D . 222 (61.6%) contained at least one substitution. 404 (74.5%) 542 changes...
Abstract We investigated the role of stattic as an adjuvant molecule to increase cytotoxicity 5‐fluorouracil (5‐FU) through specific inhibition molecular targets, signal transducer and activator transcription 3 (STAT3) nuclear factor erythroid 2–related 2 (Nrf2) in HT‐29 colon cancer cells. Cytotoxicity apoptotic effects were by methylthiazolyldiphenyl‐tetrazolium bromide assay flow cytometry analysis, respectively. Real‐time polymerase chain reaction was applied assess messenger RNA (mRNA)...
The immunosuppressive context of the tumor microenvironment (TME) is a significant hurdle in breast cancer (BC) treatment. Combinational therapies targeting core signaling pathways involved induction TME milieu have emerged as potent strategy to overcome immunosuppression and enhance patient therapeutic outcomes. This study presents compelling evidence that hypoxia-inducible-factor-1 alpha (Hif-1α) alongside chemotherapy immune-inducing factors leads substantial anticancer effects through...
Background: Chemotherapy-induced premature ovarian failure is a prevalent issue for cancer patients, and current treatment options are associated with limitations. Platelet-rich plasma (PRP) has emerged as safe straightforward option various medical conditions, including infertility. The study aims to assess the impact of PRP on follicular function granulosa cells damaged Cyclophosphamide (CTX). Methods: evaluated biological characteristics Human Granulosa Cells (HGrC1) that were 4...
AIM: To characterize the hepatitis B virus surface protein genotypes and sequence variations among HBsAg positive chronic Iranian patients from different ethnic groups. METHOD: The genes 312 were amplified directly sequenced. RESULTS: All strains (100%) belonged to genotype D subtypes ayw2. average nucleotide mutation frequency was 0.91 (dN/dS < 1.0), indicated negative selection. There no significant correlation between HBV DNA ALT levels occurrence of amino acid substitutions. However, in...
Abstract Nano silver‐based inorganic structure with the chemical formulation of [Ag(dafo) 2 (NO 3 )] ( 1 ), dafo=4,5‐diazafluoren‐9‐one, was synthesized using sonochemical method. Three different ultrasonic generator output powers 30 W, 60 90 each in two reaction temperature ranges 0–10 °C and 25–35 °C, were our conditions. After preparing compound differently‐sized nanoparticles under conditions, we conducted an evaluation study into optical, anti‐cancer, thermal activities compound. High...
Abstract The immunosuppressive tumor microenvironment (TME) plays a pivotal role in the response to various anticancer therapies, such as immune and chemotherapeutic agents. In this study, synergistic effects of gene-targeting HIF-1α siRNA combined with Toll-Like Receptor 7 agonist on TME remodeling were investigated mouse model colorectal cancer (CRC). A HIF-1α-specific duplex was formulated based ionic gelation tripolyphosphate (TPP) cationic chitosan (CH) nanoplex evaluated terms size,...
The present study investigated the prevalence of Helicobacter pylori infection in peptic ulcer patients referred to endoscopy departments Khorramabad hospitals during 2013- 2016.The early pool included all who had been department and whose endoscopic pathology reports were available complete. After recording reports, 1224 (gastric or duodenal ulcer) cases, which biopsy assays performed examine type presence bacteria, selected. Pathology collected by referring departments. information report,...
Incidence of Hepatitis B virus Surface Antigen (HBsAg) Mutations in Naïve Treated Chronic Carriers from Tehran Metropolis, Iran
Background: Recently, combination therapy has become a promising approach to overcoming chemotherapy problems. In the present study, we describe combinational treatment regime using cisplatin (Cis) and imiquimod (IMQ) increase antitumor response of in A549 lung cancer cells. Methods: cells were either treated with increasing concentrations Cis or IMQ Cis-IMQ combinations for 24h. Cell growth inhibition, cell cycle analysis, inductive apoptosis evaluated MTT assay annexin V flow cytometry,...
Abstract purpose Recently, combination therapies have become a promising approach with hopeful therapeutic outcomes due to their strong antitumor effects. Among them, despite the great success of cancer chemoimmunotherapy, it has not been able improve outcome patients. Immunosuppressive tumor microenvironment (TME) known as main barrier therapy. It assumed that targeting HIF-1α reshaping TME combined chemoimmunotherapy can capably enhance response Methods We established CT26 mouse models...
Aims: Recently, chemoimmunotherapy has become a promising approach with remarkable therapeutic outcomes. In this study, we aimed to target HIF-1α as reshaping of the immunosuppressive tumor microenvironment (TME) in combination enhance antitumor response therapy.Material and methods: The HIF signaling pathway was suppressed CT26 mouse colon cancer cells by using siRNA-loaded Chitosan nanoparticles (NPs) both vitro vivo. We assessed synergistic effect genetic silencing combined oxaliplatin...