A5071466149- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
- Multiple Sclerosis Research Studies
- Nanocluster Synthesis and Applications
- Neurological Disorders and Treatments
- Polymer Surface Interaction Studies
- Neurological Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Nerve injury and regeneration
- Lanthanide and Transition Metal Complexes
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Autophagy in Disease and Therapy
- Advanced biosensing and bioanalysis techniques
- Advanced Drug Delivery Systems
Tabriz University of Medical Sciences
2021-2023
The formation of protein corona (PC) around nanoparticles (NPs) has been reported inside biological conditions. This effect can alter delivery capacity toward the targeted tissues. Here, we synthesized folic acid-modified chitosan NPs (FA-CS NPs) using different concentrations acid (5, 10, and 20%). FA-CS were exposed to plasmas breast cancer patients healthy donors evaluate possibility PC formation. We also monitored uptake efficiency in vitro conditions after incubation with human cell...
Introduction: Blood-brain barrier with strictly controlled activity participates in a coordinated transfer of bioactive molecules from the blood to brain. Among different delivery approaches, gene is touted as promising strategy for treatment several nervous system disorders. The exogenous genetic elements limited by paucity suitable carriers. As correlate, designing high-efficiency biocarriers challenging. This study aimed deliver pEGFP-N1 plasmid into brain parenchyma using CDX-modified...
The comparison of two most promising treatment strategies multiple sclerosis (MS) including administration mesenchymal stem cells (MSCs) and targeted delivery cerebrolysin as a source neurotrophic factors (NTFs) can be clarified the future MS guidelines. This study carried out on experimental autoimmune encephalomyelitis an animal model through NTFs loaded TGN-modified chitosan nanoparticles (NTFs@TCN) MSCs administration. clinical scores considerations evaluation biological samples were...