Tumbuhan serunai (Chromolaena odorata) merupakan tumbuhan yang sering digunakan sebagai alternatif pengobatan tradisional untuk berbagai macam penyakit. Alkaloid senyawa organik ditemukan di alam berasal dari jenis tumbuhan. memiliki kemampuan dalam membantu penyembuhan luka karena aktif alkaloid aktivitas antioksidan sehingga ditingkatkan oleh dapat disebabkan aksi radikal bebas meningkatan kadar enzim antioksidan. Penelitian ini bertujuan mengetahui tiga pelarut berbeda berdasarkan tingkat...

Matrix metalloproteinases in head and neck cancer: current perspectives Ioannis Gkouveris,1 Nikolaos G Nikitakis,2 Jaya Aseervatham,1 Nanditha Rao,1 Kalu UE Ogbureke1,2 1Department of Oral Pathology, School Dentistry, National Kapodistrian University Athens, Greece; 2Department Diagnostic Biomedical Sciences, Texas Health Science Center at Houston, TX, USAAbstract: (MMPs) are zinc-dependent endopeptidases encoded by 24 distinct genes. Their functions have been implicated numerous normal...

Interleukin-37 (IL-37) has anti-inflammatory properties in innate and adaptive immunity. Patients with multiple sclerosis (MS), an autoimmune inflammatory demyelinating disease of the central nervous system (CNS), have increased serum levels IL-37. However, it is unknown whether IL-37 inhibitory effect on ongoing neuroinflammation, thus offering a potential MS therapy. Here, we examined experimental encephalomyelitis (EAE) model after onset to determine if was protective. IL-37-treated mice...

Equilibrative nucleoside transporters (ENTs) are integral membrane proteins, which reside in plasma membranes of all eukaryotic cells and mediate thermodynamically downhill transport nucleosides. This process is essential for recycling, also plays a key role terminating adenosine-mediated cellular signaling. Furthermore, ENTs the uptake many drugs, including anticancer antiviral analogues. The structure mechanism, by catalyze trans-membrane their substrates, remain unknown. To identify core...

Recent reports highlight the potential tumorigenic role of Dentin Sialophosphoprotein (DSPP) and its cognate partner Matrix Metalloproteinase 20 (MMP-20) in Oral Squamous Cell Carcinomas (OSCCs). However, function/mechanism these roles is yet to be fully established. The present study aimed investigate effects DSPP MMP20 silencing on specific proteins involved oral cancer cell adhesion, angiogenesis, metastasis, epithelial-mesenchymal transition (EMT). Stable lines DSPP/MMP20 silenced OSCC...

Recent findings indicate that dentin sialophosphoprotein (DSPP) and matrix metalloproteinase (MMP) 20 interact in oral squamous cell carcinoma (OSCC). The objective of this study was to determine the effects DSPP/MMP20 gene silencing on cancer stem (OCSC) markers. expression well-established OCSC markers: ABCG2; ALDH1; CD133; CD44; BMI1; LGR4, Podoplanin DSPP/MMP20-silenced OSCC line, OSC2, controls were assayed by western blot (WB), flow cytometry techniques. sensitivity OSC2 cells...

Connexin36 (Cx36) is the most abundant connexin in central nervous system neurons. It forms gap junction channels that act as electrical synapses. Similar to chemical synapses, Cx36-containing junctions undergo activity-dependent plasticity and complex regulation. Cx36 represent multimolecular complexes contain cytoskeletal, regulatory scaffolding proteins, which regulate channel conductance, assembly turnover. The amino acid sequence of mammalian harbors a phosphorylation site for...

Interictal Epileptiform Dischargers (IEDs), which consists of spike waves and sharp waves, in human electroencephalogram (EEG) are characteristic signatures epilepsy. Spike characterized by a pointed peak with duration 20-70 ms, while has 70-200 ms. The purpose the study was to classify wave EEG data epilepsy patients using Backpropagation Neural Network. proposed method two main stages: feature extraction stage classification stage. In stage, we use frequency, amplitude statistical feature,...

Leakage of cellular enzymes into the plasma is a clear indication cell damage.When liver membrane damaged, variety normally located in cytosol are released blood stream and their estimation quantitative marker for extent damage.The cytoprotective effect Semecarpus anacardium was evaluated rats that were rendered diabetic by administration streptozotocin at dose 50 mg/kg body weight.The activities assayed serum, kidney.The indicators renal damage such as urea, uric acid creatinine addition to...

Glucose produced by gluconeogenesis and glycogenolysis plays an important role in aggravating hyperglycemia diabetes, altered mitochondrial function is associated with impaired energy production. The present study focuses on the effect of Semecarpus anacardium carbohydrate metabolism production diabetic rats. Diabetes was induced administration Streptozotocin at a dose 50 mg/kg.b.wt. Three days after induction, 300 mg/kg.b.wt administered for 21 days. After experimental duration, activities...

Abstract Background Matrix metalloproteinases‐20 (MMP20) expression is widely regarded as tooth specific, with limited to dental hard tissues. Recently, we reported MMP20 and interaction dentin sialophosphoprotein (DSPP), a member of the Small Integrin Binding Ligand N‐linked Glycoproteins (SIBLINGs), in human oral squamous cell carcinoma (OSCC) dysplastic premalignant lesions (OPLs), suggesting role for MMP20‐DSPP carcinogenesis. Methods This study aimed survey its cognate DSPP partner...

Dentin sialophosphoprotein (DSPP) is upregulated in various human cancers, including head and neck squamous cell carcinoma. Cancer cells are commonly found under constant endoplasmic reticulum (ER) stress exhibit increased levels of misfolded proteins, due to gene mutations a stressful microenvironment. The present study examined the effects DSPP silencing on regulation ER unfolded protein response (UPR) oral cancer cells. A recently established stable short hairpin (sh)RNA-silenced OSC2...

Epilepsi is an abnormal condition of brain activity that can be recorded by using Elecktroencephalography (EEG). On epilepsy patient, most the recording interictal wave in form spike and sharp wave. This study has goal to classify whether waves are or The was conducted two stages Identification Classification. Firstly, epileptogenik were identified shifting baseline each select best contain all data wave, then doing normalization it get features frequency, amplitude 1 2. Secondly, Back...

Calmodulin binding is a nearly universal property of gap junction proteins, imparting calcium-dependent uncoupling behavior that can serve in an emergency to decouple stressed cell from its neighbors. However, junctions function as electrical synapses within networks neurons routinely encounter large fluctuations local cytoplasmic calcium concentration; frequent would be impractical and counterproductive. We have studied the properties functional consequences calmodulin synapse protein...

Oxidative and nitrosative stress play an important role in the complications of diabetes mellitus. Free radicals are produced when there is electron leak mito-chondria a change mitochondrial membrane potential. The present study was undertaken to investigate Semecarpus anacardium protecting by modulating production reactive oxygen species nitrogen diabetic rats.Diabetes induced using streptozotocin at dose 50 mg/kg body weight and, starting 3 days after induction, nut milk extract...

14-3-3s are a family of structurally similar proteins that bind to phosphoserine or phosphothreonine residues, forming the central signaling hub coordinates integrates various cellular functions, thereby controlling many pathways important in cancer, cell motility, death, cytoskeletal remodeling, neuro-degenerative disorders and more. Their targets present all compartments, when they alter their subcellular localization, stability, molecular interactions with other proteins. Changes...

Introduction: Oral carcinogenesis is a multistage process, featuring genetic and molecular alterations leading to rapid cell division, invasion, metastasis, increased survival. Many of these are due perturbations in the signaling networks, which turn lead constitutive deregulation proteins involved regulatory pathways. Our recent reports show that silencing dentin sialophosphoprotein (DSPP) its cognate matrix metalloproteinases 20 (MMP20) alters key tumorigenic hallmarks oral squamous...

Obesity is found in 90% of the world's patients with a type 2 diabetes mellitus (DM) diagnosis. If it not being treatment, disease advances to metabolic syndrome related some atherosclerotic cardiovascular diseases. In this study, mathematical model was constructed that represent prognosis DM. The started from transition vulnerable people overweight and obese. advanced makes DM sufferer become syndrome. has no disease-free critical point, while implicit endemic point guaranteed for...

Abstract Along with the development of increasingly modern life styles, risk community healthiness to gain weighted is rising due positive and negative impact social interactions. Many impacts interaction tend people such member being obese, in other way some make possibility obese normal weighted. This study discusses prognosis obesity, metabolic syndrome MS), type 2 diabetes mellitus (DM) coronary heart disease (CHD) point view factor it. Obesity main stimulator for MS, Type DM...

ABSTRACTPalu as the Capital of Central Sulawesi province is known one crafts made from ebony. Ebony woodcraft industry in Palu begin to increase with establishment several business ebony, them Sumber Urip Store that not only a shop sell crafts, but at same time place produce ebony wood . This store have 9 workers and already an adequate means production. study aimed propose hungarian method solve multi-objective assignment by optimizing cost From results obtained total producing all kinds...