A5101754487- Synthesis and bioactivity of alkaloids
- Neonatal Health and Biochemistry
- Circular RNAs in diseases
- Folate and B Vitamins Research
- Curcumin's Biomedical Applications
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Lymphoma Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Cancer-related molecular mechanisms research
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Bone Tumor Diagnosis and Treatments
- Bacterial Identification and Susceptibility Testing
Qingdao University
2019-2024
Affiliated Hospital of Qingdao University
2019-2024
Sorafenib, an orally active potent tyrosine kinase inhibitor (TKI), represented a primary treatment in patients with advanced hepatocellular carcinoma (HCC). Unfortunately, sorafenib resistance was regarded as huge obstacle for HCC treatment. RNA-sequencing including circRNA Sequencing (circRNA-Seq) circular RNAs (circRNAs), miRNA (miRNA-Seq) microRNAs (miRNAs), well mRNA (mRNA-Seq) mRNAs sorafenib-resistant cells vs sorafenib-sensitive cells, were performed. Then, interaction correlation...
Primary diffuse large B-cell lymphoma of the bone (PB-DLBCL) is an extremely rare type extra-nodal lymphoma. The clinical characteristics, management, and survival outcomes adult PB-DLBCL patients remain poorly defined. To explore manifestations, staging, therapeutic options, prognostic factors with to create a model predict outcomes. Data were obtained from Surveillance, Epidemiology, End Results (SEER) Program 18 registries database 2000 2018. Kaplan–Meier analysis was conducted calculate...
The mean unbound vancomycin fraction and whether the level could be predicted from total are still controversial, especially for patients in different groups, such as intensive care unit (ICU) versus non-ICU patients. Other relevant potential patient characteristics that may predict levels have yet to clearly determined.We enrolled a relatively large study population included widely comprehensive covariates evaluate fractions cohort of ICU (n=117 samples) (n=73 by using liquid...
1G, a novel derivative of curcumin, exhibits promising anticancer activities in various cancer cell lines. To support its further pharmacological studies, liquid chromatography–tandem mass spectrometry method was developed and validated accordance with FDA's Guidance. After extraction by protein precipitation, analytes were separated 4.5 min gradient elution (water/0.1% formic acid methanol) on reverse-phase C18 column at 40 °C. The multiple reaction monitoring mode used for quantification...