A5073616355- Hydrology and Watershed Management Studies
- Water-Energy-Food Nexus Studies
- Climate variability and models
- Peptidase Inhibition and Analysis
- Environmental and Ecological Studies
- Biosensors and Analytical Detection
- Flood Risk Assessment and Management
- SARS-CoV-2 detection and testing
- Transboundary Water Resource Management
- Regional Development and Innovation
- Natural Resources and Economic Development
- Climate change impacts on agriculture
- Precipitation Measurement and Analysis
- Global Energy and Sustainability Research
- Geography and Environmental Studies in Latin America
- Click Chemistry and Applications
- Water resources management and optimization
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Hydrology and Drought Analysis
- Cancer Immunotherapy and Biomarkers
- Climate Change, Adaptation, Migration
- IL-33, ST2, and ILC Pathways
- Inflammasome and immune disorders
- Job Satisfaction and Organizational Behavior
University Hospital Bonn
2015-2022
University of Bonn
2015-2022
West Coast University of Applied Sciences
2021
Potsdam Institute for Climate Impact Research
2012-2019
Inflammasomes are high molecular weight protein complexes that assemble in the cytosol upon pathogen encounter. This results caspase-1-dependent pro-inflammatory cytokine maturation, as well a special type of cell death, known pyroptosis. The Nlrp3 inflammasome plays pivotal role defense, but at same time, its activity has also been implicated many common sterile inflammatory conditions. To this effect, several studies have identified engagement number human diseases such atherosclerosis, 2...
Evolution of tumor cell phenotypes promotes heterogeneity and therapy resistance. Here we found that induction CD73, the enzyme generates immunosuppressive adenosine, is linked to melanoma phenotype switching. Activating MAPK mutations growth factors drove CD73 expression, which marked both nascent full activation a mesenchymal-like state program. Proinflammatory cytokines like TNFα cooperated with signaling through c-Jun/AP-1 transcription factor complex activate by binding an intronic...
An intercomparison of climate change impacts projected by nine regional-scale hydrological models for 12 large river basins on all continents was performed, and sources uncertainty were quantified in the framework ISIMIP project. The ECOMAG, HBV, HYMOD, HYPE, mHM, SWAT, SWIM, VIC WaterGAP3 applied following basins: Rhine Tagus Europe, Niger Blue Nile Africa, Ganges, Lena, Upper Yellow Yangtze Asia, Mississippi, MacKenzie Amazon America, Darling Australia. model calibration validation done...
Summary The ongoing SARS-CoV-2 pandemic has already caused devastating losses. Exponential spread can be slowed by social distancing and population-wide isolation measures, but those place a tremendous burden on society, and, once lifted, exponential re-emerge. Regular population-scale testing, combined with contact tracing case isolation, should help break the cycle of transmission, current detection strategies are not capable such large-scale processing. Here we present protocol for...
Frequent testing of large population groups combined with contact tracing and isolation measures will be crucial for containing Coronavirus Disease 2019 outbreaks. Here we present LAMP-Seq, a modified, highly scalable reverse transcription loop-mediated isothermal amplification (RT-LAMP) method. Unpurified biosamples are barcoded amplified in single heat step, pooled products analyzed en masse by sequencing. Using commercial reagents, LAMP-Seq has limit detection ~2.2 molecules per µl at 95%...
The Upper Niger and Bani River basins in West Africa. growing demand for food, water, energy led Mali Guinea to develop ambitious hydropower irrigation plans, including the construction of a new dam extension schemes. These two developments will take place upstream sensible ecosystem hotspots while feasibility development plans terms water availability sustainability is questionable. Where agricultural past decades focused mainly on intensifying dry-season crops cultivation, future include...
Abstract. Lockdown regulations during the COVID-19 outbreak resulted in abrupt changes to work situations and presented new leadership challenges. This short report explores how leaders perceived their options for leading transformationally when teams were forced rapidly switch virtual collaboration. We interviewed 20 supervisors using semistructured telephone interviews who described general behavior before lockdown evaluated possibilities difficulties of lockdown. The article provides...
Reinhardt, J., S. Liersch, M. A. Abdeladhim, Diallo, C. Dickens, Fournet, F. Hattermann, Kabaseke, Muhumuza, L. Mul, T. Pilz, I. Otto, and Walz. 2018. Systematic evaluation of scenario assessments supporting sustainable integrated natural resources management: evidence from four case studies in Africa. Ecology Society 23(1):5. https://doi.org/10.5751/ES-09728-230105