A5047485392- HIV/AIDS Research and Interventions
- Mosquito-borne diseases and control
- Syphilis Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV Research and Treatment
- Infectious Diseases and Tuberculosis
- Autoimmune and Inflammatory Disorders Research
- Immunodeficiency and Autoimmune Disorders
- Science and Education Research
- HIV/AIDS drug development and treatment
- Oral health in cancer treatment
- Viral Infections and Vectors
- Venomous Animal Envenomation and Studies
- Head and Neck Cancer Studies
- Virology and Viral Diseases
- Whipple's Disease and Interleukins
- Cholangiocarcinoma and Gallbladder Cancer Studies
- NF-κB Signaling Pathways
- Adenosine and Purinergic Signaling
- Women's cancer prevention and management
- Leech Biology and Applications
- Turtle Biology and Conservation
- Cancer Diagnosis and Treatment
- Infectious Diseases and Mycology
- Antifungal resistance and susceptibility
Prefeitura Municipal de Campos dos Goytacazes
2017-2024
Fundação Faculdade de Medicina
2019-2024
National AIDS Housing Coalition
2022
State University of Norte Fluminense
2010-2021
In the large Zika virus (ZIKV) epidemic that occurred in Brazil 2015, intrauterine fetal exposure to ZIKV was associated with a significant risk of developing microcephaly and neurological disorders infected infants. ZIKV-associated disease has since been reported 24 countries Americas. At present, definitive evidence is lacking regarding co-exposure other viral infections whether coinfection impacts acquiring either infection or severity. Here, we provide both human immunodeficiency (HIV)...
Patients with Mendelian Susceptibility to Mycobacterial Diseases (MSMD) exhibit variable vulnerability infections by mycobacteria and other intramacrophagic bacteria (e.g., Salmonella Klebsiella) fungi Histoplasma, Candida, Paracoccidioides, Coccidioides, Cryptococcus). The hallmark of MSMD is the inherited impaired production interferon gamma (IFN-γ) or lack response it. Mutations in interleukin (IL)-12 receptor subunit beta 1 (IL12RB1) gene accounts for 38% cases MSMD. Most IL12RB1...
A hallmark of imprinted genes in mammals is the occurrence parent-of-origin-dependent asymmetry DNA cytosine methylation (5mC) alleles at CpG islands (CGIs) their promoter regions. The 5mCpG between parental creates allele-specific differentially methylated regions (iDMRs). iDMRs often are coupled to transcriptional repression allele and activation unmethylated a tissue-specific, developmental-stage-specific and/or isoform-specific fashion. function as regulatory platforms, built through...
Leprosy is an infectious disease still highly prevalent in Brazil, having been detected around 27,863 new cases 2019. Exposure to Mycobacterium leprae may not be sufficient trigger the disease, which seems influenced by host immunogenetics determine resistance or susceptibility. The purinergic receptor P2X7 plays a crucial role immunity, inflammation, neurological function, bone homeostasis, and neoplasia associated with several non-infectious diseases. Here, we first compare P2RX7...
In a low-income setting with simultaneous presence of Dengue virus, Zika and Chikungunya virus (CHIKV) in the same region, difficulty establishing clinical diagnosis when molecular test is not possibility. Thus, it important to identify signs symptoms that can be used differentiate from other arboviruses children.This cross-sectional study, which was developed Rio de Janeiro State, Brazil, analysis pediatric medical records regarding arboviruses. Considering population had already been...
Better characterization of individual snake venom toxins is useful for analyzing the association their toxic domains and relevant antigenic epitopes. Here we analyzed Bitis arietans hemorrhagic-inducing toxin present in a representative sample. Among 1´ to 5´ protein peaks isolated using Sephacryl S 100 HR chromatography column, hemorrhagic activity was expressed by all according following intensity, P´5 > P´3 P´2 >, P´4. The proteins were recognized...
HIV-1 mother-to-child transmission (MTCT) is the passing of maternal to offspring during pregnancy, labor and delivery, and/or breastfeeding. MTCT evolution pediatric AIDS are multifactorial, dynamic variable phenotypic conditions. Both genetic nongenetic variables can influence susceptibility or rate progression clinical AIDS. In this review, we summarize current state knowledge about roles variations seen in host immune response genes, those that have been independently associated, mostly...
A dengue é a infecção por arbovírus com maior incidência no mundo, aumento significativo Brasil nas últimas três décadas. O controle da sua disseminação um desafio à saúde pública devido fatores como alterações climáticas, desmatamentos, migração populacional, urbanização desordenada e condições sanitárias precárias. Embora temperatura precipitação sejam variáveis importantes neste contexto, em Campos dos Goytacazes ainda não foi realizado mapeamento ambientais o acompanhamento...
In human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) patients with very low CD4 cell counts, there is a temporal relationship between administration of antiretroviral therapy (ART) an increased inflammatory response state known as the reconstitution (IRIS). The predominant clinical presentation IRIS infectious disease that can be life-threatening. IRIS-related events are distributed similarly adult males females, albeit few studies have shown skewing toward male...
Background: The main origin of functional dependence in Brazil and the world is ischemic stroke. early thrombolytic treatment reduces this morbidity. However, extended in-hospital delay risk factor for suboptimal number stroke patients who receive treatment. Objective: To describe management admitted with two Brazilian public hospitals. Methods: This cross-sectional study was carried out emergency units 2016 Campos dos Goytacazes: Hospital Ferreira Machado (HFM) Geral de Guarus (HGG). We...
Introduction: There is a need for studies to know the real situation and outline measures guarantee reduction in rates of pregnant women diagnosed with HIV, Syphilis Toxoplasmosis. Objective: To determine prevalence Syphilis, HIV toxoplasmosis puerperal assisted at largest public maternity hospital Campos dos Goytacazes 2016. Methods: Cross-sectional study, using secondary data from northern region State Rio de Janeiro, year Results: were 970 women, Toxoplasmosis pregnancy 1.6, 2.7 2%,...
Evaluation of: Lynch JB, Nduati R, Blish CA et al. The breadth and potency of passively acquired human immunodeficiency virus type 1-specific neutralizing antibodies do not correlate with the risk infant infection. J. Virol. 85(11), 5252–5261 (2011). HIV-1-infected pregnant women may transfer anti-HIV-1 antibodies, at varying lengths, extents specificities, to their babies during pregnancy via placenta after birth breast milk. In vitro, most many viral bacterial agents, present in serum, are...
Introdução: A infecção persistente por determinados genótipos do vírus papiloma humano (HPV) em mulheres é um reconhecido fator de risco para o desenvolvimento neoplasia intra-epitelial cervical. O câncer cervical a quarta causa morte no Brasil. vacinação contra HPV uma medida efetiva saúde pública prevenção Objetivo: Desenvolver teste molecular genótipo-específico HPV-16, HPV-18, HPV- 31 e HPV-45, que conjunto são responsáveis 85% dos casos Métodos: Detecção DNA viral pela técnica da reação...
PERSPECTIVA — Série “Desmistificando a ciência” Tratamento para cura do HIV-1: “O paciente de Berlim”.