A5076959418- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Alzheimer's disease research and treatments
- Maternal and Neonatal Healthcare
- Muscle metabolism and nutrition
- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Maternal Mental Health During Pregnancy and Postpartum
- Family and Disability Support Research
- Adolescent and Pediatric Healthcare
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Autism Spectrum Disorder Research
Universidade do Sul de Santa Catarina
2019-2024
Abstract Objective: To evaluate the involvement of nod-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome in schizophrenia-like behaviour young animals exposed to maternal immune activation (MIA). Methods: this aim, on 15th gestational day, females received an injection lipopolysaccharides. When completed 7, 14 and 45 postnatal days, they were killed whole brain was dissected for biochemical analysis. Animals with days submitted behavioural tests locomotor activity, social...
The neonatal immune system is still immature, which makes it more susceptible to the infectious agents. Neonatal activation associated with increased permeability of blood-brain barrier, causing an inflammatory cascade in CNS and altering behavioral neurochemical parameters. One hypotheses that has been studied neuroinflammation may be involved neurodegenerative processes, such as Alzheimer's disease (AD). We evaluate visuospatial memory, cytokines levels, expression tau GSK-3 β proteins...
Studies have shown the relationship between neuroinflammation and depressive- like parameters. However, research still has not been carried out to evaluate in neonatal period psychiatric disorders adulthood.To verify association immune activation depressive-like parameters adulthood using an animal model.Two days old C57BL/6 animals were exposed lipopolysaccharides (LPS) or phosphate- buffered saline (PBS). When 46 old, they received PBS Imipramine at 14 days. At 60 days, consumption of...
Abstract Duchenne muscular dystrophy (DMD) is one of the X-linked recessive progressive dystrophies, characterized by degeneration skeletal muscle and multisystemic involvement, including central nervous system (CNS). To investigate effects DCet on biochemical clinical parameters in a mouse model with DMD. Methods: Young adult mice (50 days old) were fed for 14 days; control groups received standard diet same period. On 14th day exposure to diets, each was submitted memory behavior...