A5036133419- Neurogenesis and neuroplasticity mechanisms
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Angiogenesis and VEGF in Cancer
- Eicosanoids and Hypertension Pharmacology
- Misinformation and Its Impacts
- Immune cells in cancer
- Vaccine Coverage and Hesitancy
- Erythropoietin and Anemia Treatment
- Dialysis and Renal Disease Management
- Adenosine and Purinergic Signaling
- Epigenetics and DNA Methylation
- Antioxidant Activity and Oxidative Stress
- Zebrafish Biomedical Research Applications
- Neonatal and fetal brain pathology
- Communication and COVID-19 Impact
- Neuroendocrine regulation and behavior
- Cellular transport and secretion
- Nitric Oxide and Endothelin Effects
- Preterm Birth and Chorioamnionitis
- Renal and related cancers
- Histone Deacetylase Inhibitors Research
- Parathyroid Disorders and Treatments
- Hip and Femur Fractures
- Blood Coagulation and Thrombosis Mechanisms
Universidad Alfonso X el Sabio
2021-2023
Baylor College of Medicine
2010-2017
Neurological Research Institute
2015-2016
Texas Children's Hospital
2015-2016
Achucarro Basque Center for Neuroscience
2016
Euskadiko Parke Teknologikoa
2016
University of the Basque Country
2016
Hospital de Cruces
2016
Hospital Universitario Fundación Jiménez Díaz
2008-2012
Universidad Autónoma de Madrid
2006
Phagocytosis is essential to maintain tissue homeostasis in a large number of inflammatory and autoimmune diseases, but its role the diseased brain poorly explored. Recent findings suggest that adult hippocampal neurogenic niche, where excess newborn cells undergo apoptosis physiological conditions, phagocytosis efficiently executed by surveillant, ramified microglia. To test whether microglia are efficient phagocytes as well, we confronted them with series apoptotic challenges discovered...
During the COVID-19 pandemic, different conspiracies have risen, with most dangerous being those focusing on vaccines. Today, there exists a social media movement focused destroying credibility of vaccines and trying to convince people ignore advice governments health organizations vaccination. Our aim was analyze antivaccination message campaign Twitter that uses Spanish as main language, find key elements in their communication strategy. data were retrieved from 14 28 December using NodeXL...
The defense mechanisms of endothelial cells (EC) against reactive oxygen species (ROS) are insufficiently characterized. We have addressed the hypothesis that vascular growth factor (VEGF) and its receptors relevant elements in this response. Cell viability, VEGF receptor (VEGFR1 VEGFR2) expression, transcription activation were studied on transient exposure monolayer EC to H2O2. Wild-type mutant inhibitors kappaBalpha (IkappaBalpha) constructions used further assess role NF-kappaB induction...
The COVID-19 pandemic has generated a great impact worldwide both on the population health but also an economic and social level. In this emergency, key element been still is need for information, which become daily concern many people. Social media represent powerful tools searching gathering health-related thus becoming new place where authorities to be present disseminate information of preventive measures like vaccines against COVID-19, as well try block these public measures. main goal...
The relative importance of cyclophilin (CyP) versus calcineurin (Cn)-mediated mechanisms in the effect cyclosporin A (CsA) on endothelial cells (ECs) is largely unknown. In cultured ECs, CsA was cytotoxic/proapoptotic or cytoprotective/antiapoptotic at high low concentrations, respectively. analogs (MeVal-4-CsA and MeIle-4-CsA), which bind to CyP but do not inhibit Cn, closely reproduced effects. Based our previous data, role vascular growth factor (VEGF) as a mediator CsA-induced...
Hydrogen peroxide (H2O2) formation is a critical factor in processes involving ischaemia/ reperfusion. However, the precise mechanism by which reactive oxygen species (ROS) induce vascular damage are insufficiently known. Specifically, activation of phospholipase C gamma (PLCgamma) probable candidate pathway involved smooth muscle cells (VSMC) H2O2.The human venous VSMC was measured as cytosolic free calcium mobilization, shape change and protein phosphorylation, focusing on role tyrosine...
Transcriptional regulation of vascular endothelial growth factor (VEGF) is critically dependent on hypoxia-inducible 1 (HIF-1). However, not only hypoxia, but selected factors can induce HIF-1. High levels both VEGF and HIF-1 coexist in certain conditions, e.g. tumors. Nonetheless, the possibility that stimulatory relationship between may be bi-directional has been addressed up to date. The present study cells analyzed whether regulated by a product its own transcriptionally activated genes,...
Background. Recent studies have shown that exogenous administration of vascular endothelial growth factor (VEGF) is protective against cyclosporine A (CsA) renal toxicity. No data are available, however, on the possible role endogenous VEGF. Our objective was to examine whether VEGF has a significant in response CsA Methods. In vivo, we used high-dose (50–150 mg/kg/day) ± specific goat anti-mouse blocking monoclonal antibody (α-VEGF) mice. vitro, exposed mouse tubular cells (MCT) α-VEGF....
Abstract In the present study, we have investigated distribution and origin of catecholaminergic innervation septal region in frog Rana perezi . Immunohistochemistry for dopamine two enzymes required synthesis catecholamines, tyrosine hydroxylase (TH) β‐hydroxylase (DBH) revealed a complex pattern (CA) anuran septum. Dopaminergic fibers were primarily dorsal portion lateral septum, whereas noradrenergic (DBH immunoreactive) predominated medial septum/diagonal band complex. Catecholaminergic...
Proangiogenic, proliferative effects of tumors have been extensively characterized in subconfluent endothelial cells (EC), but results confluent, contact-inhibited EC are critically lacking. The present study examined the effect tumor-conditioned medium (CM) malignant osteoblastic cell line MG63 on monolayer, quiescent bovine aorta EC. MG63-CM and + CoCl(2) significantly increased survival serum-starved conditions, without inducing proliferation. Furthermore, CoCl(2), both containing high...
Adult hippocampal neurogenesis, the process of formation new neurons, occurs throughout life in hippocampus. New neurons have been associated with learning and memory as well mood control, impaired neurogenesis has linked to depression, schizophrenia, autism cognitive decline during aging. Thus, understanding biological properties adult important implications for human health. Computational models attempted derive biologically relevant knowledge, hard achieve using experimentation. However,...
AG490 is a tyrphostin originally described as Janus Activated Kinase (JAK) 2 inhibitor. also inhibits epidermal growth factor receptor (EGFR) and guanylyl cyclases (GC). More recently, was associated with oxidative stress protection in experimental acute kidney injury models. We now show that strong activator of the Hypoxia Inducible Factor (HIF)-1. Under normoxic conditions HIF-1α degraded through hydroxylation, von Hippel Lindau protein (VHL)-mediated ubiquitin tagging proteasomal...
The vaccines against COVID-19 arrived in Spain at the end of 2020 along with vaccination campaigns which were not free controversy. debate was fueled by adverse effects following administration AstraZeneca-Oxford (AZ) vaccine some European countries, eventually leading to its temporary suspension as a precautionary measure. In present study, we analyze healthcare professionals’ conversations, sentiment, polarity, and intensity on social media during two periods 2021: one closest AZ same time...