A5027099185- Adipose Tissue and Metabolism
- Natural Antidiabetic Agents Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Exercise and Physiological Responses
- Phytochemicals and Antioxidant Activities
- Immune Response and Inflammation
- Cardiovascular Disease and Adiposity
- Patient Safety and Medication Errors
- Cardiac tumors and thrombi
- Eicosanoids and Hypertension Pharmacology
- Coronary Artery Anomalies
- Diet, Metabolism, and Disease
- Biological and pharmacological studies of plants
- Respiratory Support and Mechanisms
- Travel-related health issues
- Cardiac Structural Anomalies and Repair
- Regulation of Appetite and Obesity
- Healthcare Quality and Management
- Metabolism, Diabetes, and Cancer
- Cardiovascular and exercise physiology
- Cardiovascular Function and Risk Factors
- Pharmaceutical Practices and Patient Outcomes
- Cholinesterase and Neurodegenerative Diseases
- Tryptophan and brain disorders
- Advanced Glycation End Products research
Mashhad University of Medical Sciences
2019-2024
Background: Exercise training could be essential in preventing pathological cardiac remodeling diabetes. Therefore, the effects of moderate-intensity continuous (MICT) and high-intensity interval (HIIT) singly or plus metformin on diabetes-induced cardiomyopathy were investigated this study. Methods: Forty-nine Wistar rats (male) recruited. Seven groups animals treated for six weeks as control, diabetes, MICT (15 m/min, 40 min/day), HIIT (20 (300 mg/kg), HIIT+metformin (Met-HIIT),...
Abstract Sepsis is associated with brain injury and acute inflammation, which can potentially transition into chronic triggering a cascade of inflammatory responses that may lead to neurological disorders. Minocycline, recognized for its potent anti‐inflammatory properties, was investigated in this study protective effects against sepsis‐induced injury. Adult male C57 mice pretreated minocycline (12.5, 25, 50 mg/kg) 3 days before sepsis induction. An intraperitoneal injection 5 mg/kg LPS...
Diabetic cardiomyopathy (DCM), as a ventricular dysfunction, is one of the main causes death in diabetic patients. Former evidence revealed beneficial effects exercise on cardiovascular complications diabetes. We aimed to investigate high-intensity interval training (HIIT) and moderate-intensity continuous (MICT) DCM. Male Wistar rats were divided into control, diabetic, metformin (300 mg/kg), HIIT, MICT, + MICT groups. Serum biochemical, inflammatory, oxidative stress indicators, gene...
Inflammatory process and apoptosis are involved in the pathogenesis of cardiac injury oxidative damage caused by diabetes mellitus. The cardioprotective effects standardized aqueous ethanolic olive leaf extract (OLE), metformin (as a cardiovascular protective agent) valsartan an angiotensin receptor blocker) streptozotocin-induced diabetic rats were evaluated.Wistar divided into control, diabetic, OLE-treated (100, 200 400 mg/kg), (300 mg/kg)-treated, (30 mg/kg)-treated...
Diabetes has a negative effect on learning and memory performance, it is risk factor for Alzheimer's disease dementia development. The present study aims to investigate the effects of two kinds endurance exercise including high-intensity interval training (HIIT) moderate-intensity continuous (MICT) as well metformin impaired related streptozotocin (STZ) induced diabetes in rats.Forty adult male rats (250 ± 20 g weight) were divided into five groups (n=8), control, diabetic, diabetic treated...
Given the heightened risk of diabetes-related cardiovascular events associated with inactivity, this study investigates molecular mechanisms vascular damage in streptozotocin (STZ)-induced diabetic rats. The aim is to elucidate impact different exercises (interval and continuous training) metformin on biochemical parameters, aortic injury, oxidative stress, inflammation provide insights into potential therapeutic interventions for diabetes-associated complications. Male Wistar rats were...
Primary cardiac tumors are rare, and approximately 90% of them benign. Myxoma is the most common type these occurring in left atrium 75-85% cases. The tumor can cause atrio-ventricular valve obstruction embolization phenomenon. Case presentation We reported a case 54-year-old man with complaints dyspenea amnesia. In our patient, transthoracic echocardiography revealed mass 28*63 mm attached to upper intra-atrial septum, which was prolapsing through mitral into ventricle during diastole,...
Abstract Oxidative stress has an important role in brain aging and its consequences include cognitive decline physiological disorders. Peroxisome proliferator‐activated receptor‐γ (PPARγ) activation been suggested to decrease oxidative stress. In the current research, effect of PPARγ by pioglitazone(Pio) on learning, memory was evaluated aged rats. The rats were divided into five groups. Control group, vehicle (saline‐diluted dimethyl sulfoxide (DMSO)) saline injected instead Pio scopolamine...
Abstract Objectives Regarding neurocognitive and immunomodulatory properties of cinnamon (Cinn) we aimed to investigate whether regulates acetylcholinesterase (AChE) activity, oxidative abnormalities with concomitant memory dysfunction in streptozotocin (STZ)-induced diabetes. Methods Forty-seven male adult rats were divided into seven groups (n=8 animals): Control group: these non-diabetic only saline 0.9% NaCl was gavaged, Diabetic (Dia) diabetic them gavaged for six weeks. Dia-Cinn 100,...
Aim: Sepsis is associated with brain injury and acute inflammation, which can potentially transition into chronic triggering a cascade of inflammatory responses that may lead to neurological disorders. Minocycline, recognized for its potent anti-inflammatory properties, particularly within the brain, was investigated in this study protective effects against sepsis-induced injury. Methods: Adult male C57 mice received pretreatment varying doses minocycline (12.5, 25, 50 mg/kg) three days...
ABSTRACT Acetaminophen (APAP) is a well‐known drug that, in high doses, induces hepatotoxicity and nephrotoxicity. This study has investigated the preventive effect of extract fractions Ribes khorasanicum on APAP‐induced liver kidney damage. In this experiment, after analysis using FTIR, toxicity was induced by APAP 7th day. Before their aqueous, ethyl acetate, n‐hexane were administrated orally. 24 h administration, animals sacrificed. The removed for evaluation oxidation biochemical...
Diabetic cardiomyopathy (DCM), as a ventricular dysfunction, is one of the main causes death in diabetic patients. Former evidence revealed beneficial effects exercise on diabetes-induced cardiovascular complications. We aimed to investigate high-intensity interval training (HIIT) and moderate-intensity continuous (MICT) cardiac damage during DCM. For this purpose, wistar rats were divided into control, diabetic, metformin (300 mg/kg)-treated, HIIT, MICT, metformin+HIIT, metformin+MICT...
Introduction: Exercise training could be considered an important strategy in preventing cardiac pathologic remodeling diabetes. This research aimed to investigate the effects of high-intensity interval training(HIIT)and moderate-intensity continuous training(MICT)alone and combination with metformin on diabetic cardiomyopathy.Method: The forty-nine male Wistar rats were recruited exposed different treatments. Animals divided into seven groups; control, diabetes, metformin(300 mg/kg), HIIT(20...