A5100434628- Neurobiology and Insect Physiology Research
- Insect Resistance and Genetics
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Insect and Arachnid Ecology and Behavior
- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- Neonatal and fetal brain pathology
- Spider Taxonomy and Behavior Studies
- Head and Neck Surgical Oncology
- Pharmacological Effects and Toxicity Studies
- Genomics and Phylogenetic Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Insect and Pesticide Research
- Nasal Surgery and Airway Studies
- Blood transfusion and management
- Cancer, Lipids, and Metabolism
- Synthesis and Reactions of Organic Compounds
- Stress Responses and Cortisol
- Moyamoya disease diagnosis and treatment
- Spondyloarthritis Studies and Treatments
- Neuroscience of respiration and sleep
- Osteomyelitis and Bone Disorders Research
- Ion Transport and Channel Regulation
- Sinusitis and nasal conditions
Army Medical University
2016-2025
Xinqiao Hospital
2021-2025
Shenyang Normal University
2024
Nanjing Agricultural University
2018-2024
58.com (China)
2024
Yangzhou University
2024
Chongqing Medical University
2009-2023
Second Affiliated Hospital of Chongqing Medical University
2021-2023
Dalian Medical University
2021-2023
Peking University
2014-2022
<h2>Abstract</h2><h3>Introduction</h3> In the phase 3 CheckMate 9LA study, nivolumab plus ipilimumab with chemotherapy prolonged overall survival (OS) versus alone. We report updated efficacy/safety (≥3 years' follow-up), clinical outcomes in patients baseline brain metastases, and exploratory somatic mutation analyses. <h3>Methods</h3> Adults stage IV/recurrent non–small cell lung cancer (NSCLC), no known sensitizing <i>EGFR</i>/<i>ALK</i> alterations, Eastern Cooperative Oncology Group...
Organized cardiomyocyte alignment is critical to maintain the mechanical properties of heart. In this study, we present a new and simple strategy fabricate biomimetic microchip designed with an onion epithelium-like structure investigate guided behavior human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) on substrate. The hiPSC-CMs were observed be confined by three dimensional surficial features morphologically, analogous in vivo microenvironment, exhibited organized...
Severe hypocalcemia (SH) is a common and serious complication in dialysis patients with secondary hyperparathyroidism (SHPT) after parathyroidectomy (PTX). The aim to explore the risk predictors of SH post-PTX ESRD SHPT. 129 consecutive SHPT underwent PTX were retrospectively reviewed. A total 22 clinical parameters included study. was defined as minimum values serum calcium lower than 1.875 mmol/L (7.5 mg/dL) surgery. Univariate analysis showed that pruritus, lumbar X-ray changes renal...
Introduction: Temporal lobe epilepsy (TLE) is the most common subtype of in adults and characterized by neuronal loss, gliosis, sprouting mossy fibers hippocampus. But mechanism underlying loss has not been fully elucidated. A new programmed cell death, cuproptosis, recently discovered; however, its role TLE clear. Methods: We first investigated copper ion concentration hippocampus tissue. Then, using Sample dataset E-MTAB-3123 dataset, we analyzed features 12 cuproptosis-related genes TLEs...
Coleoptera is the largest taxa of animals by far. The robust reproductive capacity one main reasons for such domination. Successful female reproduction partially relies on effective vitellogenesis. However, hormone regulation vitellogenesis remains to be explored. In present paper, in vitro culture Leptinotarsa decemlineata 1-day-old adult fat bodies 20E-contained median did not activate juvenile production and insulin-like peptide pathways, but significantly stimulated expression two LdVg...
During choriogenesis in insects, chorion (eggshell) is formed by surrounding follicular epithelial cells ovarioles. However, the regulatory endocrine factor(s) activating and chemical components on eggshell deserve further exploration. In two representative Coleopterans, a Coccinellid Henosepilachna vigintioctopunctata Chrysomelid Leptinotarsa decemlineata, genes encoding 20-hydroxyecdysone (20E) receptor heterodimer, ecdysone (EcR) ultraspiracle (USP), chitin biosynthesis enzymes...
Three new species of the genus Belisana Thorell, 1898 are described from karst caves in Guangxi, China: langping Zhang, Li & Yao, sp. nov. (♂♀), B. lingui and tianyang (♂♀). In addition, a list all Guangxi is also provided.
Calanthe fimbriata is a Tujia ethnic medicine with various medicinal value and it traditionally used for the treatment of gastric ulcer, chronic hepatitis, pharyngitis, so on.The current study was conducted to evaluate antidiabetic activity C. methanol extract (CfME) in oral glucose tolerance test (OGTT) mice streptozotocin (STZ)-induced diabetic mice.Experimental diabetes induced by intraperitoneal injection STZ (60 mg/kg) three consecutive days mice. OGTT α-glucosidase inhibition assay...
The aim of this study was to evaluate the impact different guided bone regeneration (GBR) procedures on graft contour after wound closure in lateral ridge augmentation. A total 48 patients with 63 augmented sites were included study. Participants divided into 4 groups (n = 12 each group) based surgical procedures: group 1: particulate substitute + collagen membrane; 2: membrane healing cap, 3: injectable platelet-rich fibrin (i-PRF) 4: i-PRF template membrane. After closure, thickness labial...
Infantile spasms (IS) are an age-specific epileptic syndrome with specific clinical symptom and electroencephalogram (EEG) features, lacking treatment options, a poor prognosis. Excessive endogenous corticotropin-releasing hormone (CRH) in infant brain might result IS. However, the data from human IS limited. In our study, we investigated expressions of CRH its receptor type 1 (CRHR1) surgical tissues patients autopsy controls.Specimens surgically removed 17 IS, six controls were included...
Background Glucocorticoid receptors (GRs) and mineralocorticoid (MRs) are involved in neuronal excitability, neurogenesis, neuroinflammation. However, the roles of GRs MRs epilepsy focal cortical dysplasia II (FCDII) have not been reported.Research Design Methods We evaluated expression distribution FCDII patients methylazoxymethanol-pilocarpine-induced model rats (MP rats), effects a GR agonist on neurons human investigated electrophysiological properties rats’ after lentivirus-mediated...
Introduction Preoperative autologous blood donation (PABD) can be used to reduce the exposure of allogeneic transfusion in patients undergoing elective surgery. Better management avoid anaemia and after spine surgery become increasingly important with development enhanced recovery We present here design a randomised controlled trial three groups verify clinical effectiveness PABD at high risk for lumbar fusion explore optimal timing donation. Method analysis Patients (age 18–70 years) who...
Abstract Henosepilachna vigintioctopunctata is a serious defoliating beetle attacking Solanaceae and Cucurbitaceae plants in many Asian countries. In the present paper, we identified putative myoglianin ( myo ) gene. Hvmyo was actively transcribed throughout development, from embryo to adult. RNA interference (RNAi)‐aided knockdown of delayed larval development by more than 2 days, reduced body size, inhibited growth antennae, wings legs disturbed gut purge. Knockdown impaired larval‐pupal...
Abstract In this study, polyethylene (PE)/polystyrene (PS) polymeric gradient material with spatially structure was prepared continuously by a new technique through coextrusion–gradient distribution–two‐dimensional mixing conventional processing facilities. The line from coextrusion, distribution to two‐dimensional fulfilled two extruders, unit, and units, respectively. unit units were designed separately in our group. variation of composition along the sample thickness direction studied...
Athetis lepigone Möschler (Lepidoptera, Noctuidae) is a common maize pest in Europe and Asia. However, there no long-term effective management strategy available yet to suppress its population. Adults rely heavily on olfactory cues locate their optimal host plants oviposition sites. Pheromone-binding proteins (PBPs) are believed be responsible for recognizing transporting different odorant molecules interact with receptor membrane proteins. In this study, the ligand-binding specificities of...
Background: By including untreated obstructive sleep apnea-hypopnea syndrome (OSAHS) patients as the control group, this study explores influence of minimally invasive surgical treatment and continuous positive airway pressure (CPAP) therapy on OSAHS patients, with subjective objective performance. The also discusses their relationship, determines effect factor, provides a simple practical method for evaluation clinical efficacy. Methods: A total 90 who were diagnosed in Sleep Disorders...
Ischemia and hemorrhage of pituitary adenomas (PA) caused important clinical syndrome. However, the differences on characteristics surgical outcomes between these two kinds apoplexy were less reported.A retrospective analysis was made patients with January 2013 June 2018. Baseline before surgery reviewed. All underwent transsphenoidal followed up at least 1 year.Total 67 cases (5.8%) among 1147 tumor enrolled, which consisted 28 (~2.4%) ischemic PA 39 (~3.4%) hemorrhagic PA. There more male...
Cortical dysplasia (CD) is a common cause of drug-resistant epilepsy. Increasing studies have implicated innate immunity in CD with However, it unclear whether immune factors induce epileptogenic CD. Here, we injected recombinant human high mobility group box 1 (rHMGB1) into embryonic rat ventricles to determine rHMGB1 can pathophysiological characteristics similar those Compared controls and 0.1 μg rHMGB1-treated rats, the cortical organization was severely disrupted 0.2 microgyria...
Abstract Background Orthopedic surgery for cervical torticollis poses potential threat to airway management both in tracheal intubation and extubation. Klippel-Feil syndrome (KFS) is a complex of osseous visceral anomalies. The anatomical characteristics KFS might have significant implications management. Case presentation This rare case an 8-year-old boy presenting with torticollis, congenital occipito-atlantal deformity, basilar invagination undergone elective correction surgery. Though...