A5048894740- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Pluripotent Stem Cells Research
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Viral Infections and Immunology Research
- Cardiac Fibrosis and Remodeling
- Cardiac Arrhythmias and Treatments
- Tissue Engineering and Regenerative Medicine
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Cardiac Ischemia and Reperfusion
- Alkaline Phosphatase Research Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- CRISPR and Genetic Engineering
- Synthesis and biological activity
- Neuroscience and Neural Engineering
- Pulmonary Hypertension Research and Treatments
- Cardiac pacing and defibrillation studies
- Liver Disease Diagnosis and Treatment
- Acute Myocardial Infarction Research
The University of Sydney
2020-2025
Westmead Hospital
2014-2025
Westmead Institute for Medical Research
2020-2025
University of Toronto
2024
University of Lübeck
2024
Royal North Shore Hospital
2022-2023
Westmead Institute
2021
Madras Medical College
2021
Institute of Child Health
2021
Preclinical data have confirmed that human pluripotent stem cell-derived cardiomyocytes (PSC-CMs) can remuscularize the injured or diseased heart, with several clinical trials now in planning recruitment stages. However, because ventricular arrhythmias represent a complication following engraftment of intramyocardially injected PSC-CMs, it is necessary to provide treatment strategies control prevent (EAs). Here, we show porcine model myocardial infarction and PSC-CM transplantation EAs are...
After myocardial infarction (MI), fibroblasts progress from proliferative to myofibroblast states, resulting in fibrosis. Platelet-derived growth factors (PDGFs) are reported induce fibroblast proliferation, differentiation, and However, we have previously shown that PDGFs improve heart function post-MI without increasing We treated human cardiac with PDGF isoforms then performed RNA sequencing show reduced differentiation downregulated cell cycle pathways. Using mouse/pig MI models, reveal...
BACKGROUND: Cardiac magnetic resonance imaging (CMR)–defined ventricular scar and anatomic conduction channels (CMR-CCs) offer promise in delineating tachycardia substrate. No studies have validated with coregistered histology, nor they ascertained the histological characteristics of deceleration zones (DZs) within these channels. We aimed to validate CMR CMR-CCs whole-heart histology electroanatomic mapping a postinfarction model. METHODS: Five sheep underwent anteroseptal infarction....
Cancer patients often require complex and expensive admissions necessitating multiple investigations. We conducted an audit of cost imaging performed on medical oncology inpatients in a teaching hospital New South Wales.Our overall aim was to assess appropriateness studies inpatients.Data were collected 219 consecutive evaluable admitted Westmead Hospital (August-October 2012). A panel doctors assessed imaging.The total expenditure for the cohort $106,488.15 over 624 investigations (range:...
4,6-Diaryl substituted-4,5-dihydro-2-amino pyrimidines have been synthesized by the reaction of chalcones with guanidine nitrate. Their chemical structures confirmed means IR and NMR data elemental analysis. The compounds were screened for antibacterial activity against 16 gram-positive bacterial strains in minimum inhibitory concentration. concentration compound II has found to be better than reference standards taken screening. Sulphamethoxazole trimethoprim as standards.
Purpose To assess the correlation between noninvasive cardiac MRI–derived parameters with pressure-volume (PV) loop data and evaluate changes in left ventricular function after myocardial infarction (MI). Materials Methods Sixteen adult female swine were induced MI, six used as controls 10 receiving platelet-derived growth factor-AB (PDGF-AB). Load-independent measures of function, including slopes end-systolic relationship (ESPVR) preload recruitable stroke work (PRSW), obtained on day 28...
Motivation: Knowledge that a suboptimal acquisition protocol was being implemented in large and expensive animal research study. Goal(s): Demonstration of improved image quality porcine study investigating remuscularisation effects stem cell treatment diseased injured hearts. Approach: Implementation FB tandem with BH subset subjects (n=38) who had undergone percutaneous induction myocardial infarction. Results: Superior greater reproducibility techniques shorter scan times results the need...
ABSTRACT Drug‐coated balloon (DCB) catheters offer an alternative to drug‐eluting stents (DES) by delivering anti‐proliferative drugs directly vessel walls, avoiding implantation of a permanent metallic structure. While DCBs have shown efficacy for in‐stent restenosis, evidence their application in de novo coronary disease and chronic total occlusion (CTO) PCI is growing. We present case 49‐year‐old male with multivessel subtotal occlusions who had complete percutaneous revascularisation...
Myocardial infarction is one of the leading causes death and disability worldwide, there an urgent need for novel cardioprotective or regenerative strategies. An essential component drug development determining how a therapeutic to be administered. Physiologically relevant large animal models are critical importance in assessing feasibility efficacy various delivery Due their similarities humans cardiovascular physiology, coronary vascular anatomy, heart weight body ratio, swine preferred...
To develop and test an intra-cardiac catheter fitted with accelerometers to detect acute pericardial effusion prior the onset of hemodynamic compromise.
Glycoproteins in the viral envelope of human cytomegalovirus (HCMV) orchestrate virion tethering, receptor recognition and fusion with cellular membranes. The glycoprotein gB acts as protein. gHgL complexes gHgLgO gHgLpUL(128,130,131A) define HCMV cell tropism. Studies lacking gO had indicated that gO, independently binding to its PDGFR alpha, plays an important second role infection. Here, we identified a mutation which abolished virus particle infectivity by preventing interaction host...
Breath-held (BH) cardiac magnetic resonance imaging (CMR) is the gold standard for volumetric quantification. However, large animals pre-clinical research are unable to voluntarily breath-hold, necessitating general anaesthesia and mechanical ventilation, increasing costs affecting cardiovascular physiology. Conducting CMR in lightly sedated, free-breathing (FB) animal subjects an alternative strategy which can overcome these constraints, however, may result poorer image quality due...