A5100775598- MicroRNA in disease regulation
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Bladed Disk Vibration Dynamics
- Cancer, Lipids, and Metabolism
- Extracellular vesicles in disease
- Kruppel-like factors research
- Mitochondrial Function and Pathology
- DNA Repair Mechanisms
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Birth, Development, and Health
- RNA Research and Splicing
- Metabolism and Genetic Disorders
- RNA and protein synthesis mechanisms
- Adhesion, Friction, and Surface Interactions
- interferon and immune responses
- Brake Systems and Friction Analysis
- Genetic factors in colorectal cancer
- Machine Learning in Bioinformatics
- Colorectal Cancer Treatments and Studies
- Computational Drug Discovery Methods
Liaoning University of Traditional Chinese Medicine
2025
The 180th Hospital of PLA
2016-2023
Xi'an Polytechnic University
2022
Anhui Provincial Hospital
2014
Anhui Medical University
2014
China Academy of Launch Vehicle Technology
2002
Hepatocellular carcinoma (HCC) cells-secreted exosomes (exo) could stimulate M2 macrophage polarization and promote HCC progression, but the related mechanism of long non-coding RNA distal-less homeobox 6 antisense 1 (DLX6-AS1) with HCC-exo-mediated is largely ambiguous. Thereafter, this research was started to unearth role DLX6-AS1 in HCC-exo through microRNA (miR)-15a-5p/C-X-C motif chemokine ligand 17 (CXCL17) axis.DLX6-AS1, miR-15a-5p CXCL17 expression tissues cells were tested. Exosomes...
This study aims to investigate the impact of subclinical hypothyroidism (SCH) during pregnancy on mitochondrial DNA (mtDNA) methylation in brain tissues rat offspring. Sixteen SD rats were randomly divided into two groups: control group (CON) and SCH group. BS-seq sequencing was used analyze mtDNA levels offspring's tissues; 2,7-dichlorofluorescin diacetate (DCFH-DA) probe method employed detect reactive oxygen species (ROS) electron microscopy utilized observe structure hippocampal In...
Cancer is one of the main diseases threatening human life, accounting for millions deaths around world each year. Traditional physical and chemical methods cancer treatment are extremely time-consuming, lab-intensive, expensive, inefficient difficult to be applied in a high-throughput way. Hence, it an urgent task develop automated computational enable fast accurate identification anticancer peptides (ACPs). In this paper, we novel model named iACP-GE identify ACPs. Multi-features extracted...
Background: MicroRNA-145-5p (miR-145-5p) reportedly inhibits hepatocellular carcinoma (HCC) by targeting ARF6, SPATS2, CDCA3, KLF5, and NRAS, indicating that miR-145-5p plays an important role in the occurrence development of HCC regulating expression various genes. In this study, we aimed to explore novel downstream targets elucidate potential mechanism HCC. Materials Methods: A bioinformatics analysis was performed determine clinical significance alpha/beta hydrolase domain-containing...
Abstract S-palmitoylation is a reversible protein lipidation that controls the subcellular localization and function of targeted proteins, including oncogenes such as N-RAS. The depalmitoylation enzyme family ABHD17s can remove from N-RAS to facilitate cancer development. We previously showed ABHD17C has oncogenic roles in hepatocellular carcinoma (HCC) cells, its mRNA stability controlled by miR-145-5p. However, it still unclear whether regulated at post-translational level. In present...
XRCC1 associated with liver cancer genotype (OR = 1.95, 95%CI 1.40-2.70,P < 0.0001).For c.1686C>G, the risk of HCC was significantly higher for GG compared CC wild 1.89, 1.375-2.599,P 0.0001).Significant differences in were also found other genetic models these two SNPs.The G allele both c.910A>G and c.1686C>G may contribute to (G versus A: OR 1.40, 1.20-1.64,P 0.0001 C: 1.38, 1.19-1.61,P 0.0001, respectively).Our findings suggest that polymorphisms are Chinese population.
A hybrid method is established by combining photoelastic experiment and finite element analysis. The used to evaluate contact stress distribution on dry friction interfaces, such as the interfaces between shrouds of fan blades turbine blades. frozen decide displacement boundary conditions numerical calculation. Higher accuracy efficiency solving problems are improved method. Technical difficulty high cost also avoided Good agreement using obtained.
Objective To study the relationship of microRNA-145(miR-145) and CD44 in hepatocellular carcinoma(HCC). Methods 13 clinical samples HCC tissues corresponding normal liver were collected at department General Surgery, Second Affiliated Hospital Fujian Medical University from October 2015 to June 2016. The patients with positive expression studied. levels miR-145 detected by real-time quantitative PCR. Western blot was performed detect cells Hep G2 SNU423. Biological information methods...