A5046637384- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Influenza Virus Research Studies
- Bioinformatics and Genomic Networks
- Genomics and Phylogenetic Studies
- COVID-19 Clinical Research Studies
- CRISPR and Genetic Engineering
- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Genomics and Chromatin Dynamics
- Cell Image Analysis Techniques
- Epigenetics and DNA Methylation
Institute of Structural and Molecular Biology
2016-2020
University College London
2016-2020
Abstract CATH (https://www.cathdb.info) identifies domains in protein structures from wwPDB and classifies these into evolutionary superfamilies, thereby providing structural functional annotations. There are two levels: CATH-B, a daily snapshot of the latest domain superfamily assignments, CATH+, with additional derived data, such as predicted sequence domains, functionally coherent subsets (Functional Families or FunFams). The CATH+ release, version 4.3, significantly increases coverage an...
Abstract SARS-CoV-2 has a zoonotic origin and was transmitted to humans via an undetermined intermediate host, leading infections in other mammals. To enter host cells, the viral spike protein (S-protein) binds its receptor, ACE2, is then processed by TMPRSS2. Whilst receptor binding contributes range, S-protein:ACE2 complexes from animals have not been investigated widely. predict infection risks, we modelled 215 vertebrate species, calculated changes energy of complex caused mutations each...
// Harshnira Patani 1, * , Tom D. Bunney Nethaji Thiyagarajan 1 Richard A. Norman 2 Derek Ogg Jason Breed Paul Ashford Andrew Potterton Mina Edwards Sarah V. Williams 3 Gary S. Thomson 4 Camilla S.M. Pang Margaret Knowles Alexander L. Breeze Christine Orengo Chris Phillips Matilda Katan Institute of Structural and Molecular Biology, Division Biosciences, University College London, Gower St, London WC1E 6BT, UK Discovery Sciences, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire...
Abstract Tumour sequencing identifies highly recurrent point mutations in cancer driver genes, but rare functional are hard to distinguish from large numbers of passengers. We developed a novel computational platform applying multi-modal approach filter out passengers and more robustly identify putative genes. The primary enrichment CATH families (CATH-FunFams) – structurally functionally coherent sets evolutionary related domains. Using structural representatives CATH-FunFams, we...
Abstract SARS-CoV-2 has a zoonotic origin and was transmitted to humans via an undetermined intermediate host, leading infections in other mammals. To enter host cells, the viral spike protein (S-protein) binds its receptor, ACE2, is then processed by TMPRSS2. Whilst receptor binding contributes range, S-protein:ACE2 complexes from animals have not been investigated widely. predict infection risks, we modelled 215 vertebrate species, calculated changes energy of complex caused mutations each...
Tumour sequencing identifies highly recurrent point mutations in cancer driver genes, but rare functional are hard to distinguish from large numbers of passengers. We developed a novel computational platform applying multi-modal approach filter out passengers and more robustly identify putative genes. The primary enrichment CATH families (CATH-FunFams) – structurally functionally coherent sets evolutionary related domains. Using structural representatives CATH-FunFams, we subsequently seek...