A5018471324- Nanoparticle-Based Drug Delivery
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Nanoplatforms for cancer theranostics
- Synthesis and Characterization of Heterocyclic Compounds
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Quantum Dots Synthesis And Properties
- Intraperitoneal and Appendiceal Malignancies
- Lanthanide and Transition Metal Complexes
- Pigment Synthesis and Properties
- Magnetism in coordination complexes
- Silicon Nanostructures and Photoluminescence
- Graphene and Nanomaterials Applications
- Bone Tissue Engineering Materials
- Catalytic Processes in Materials Science
- Advanced MRI Techniques and Applications
- Ferrocene Chemistry and Applications
- Inorganic and Organometallic Chemistry
- Iron oxide chemistry and applications
- Dendrimers and Hyperbranched Polymers
- Asthma and respiratory diseases
- Mast cells and histamine
- Characterization and Applications of Magnetic Nanoparticles
Universitat Autònoma de Barcelona
2019-2024
Institute for Biomedicine
2020
Infection diseases are a major threat to global public health, with nosocomial infections being of particular concern. In this context, antimicrobial coatings emerge as promising prophylactic strategy reduce the transmission pathogens and control infections. Here, door handle covers prevent cross-contamination prepared by incorporating iodine-loaded UiO-66 microparticles into potentially biodegradable polyurethane polymer (Baycusan eco E 1000). These incorporate MOF particles that serve both...
The growing concern over the toxicity of Gd-based contrast agents used in magnetic resonance imaging (MRI) motivates search for less toxic and more effective alternatives. Among these alternatives, iron-iron oxide (Fe@FeOx) core-shell architectures have been long recognized as promising MRI while limited information on their engineering is available. Here we report synthesis 10 nm large Fe@FeOx nanoparticles, coating with a 11 thick layer dense silica functionalization by 5 kDa PEG chains to...
Abstract Five copper complexes supported by terpyridine ligands were prepared and characterized, viz . [Cu 3 Cl 4 (naphtpy) 2 ][CuCl ] ( 1 ), ](ClO ) [CuCl (naphtpy)] (MeOH) (H O) (Cltpy)] [Cu(Cltpy) 5 ); (where naphtpy stands for 4’‐((naphthalen‐2‐yl)methoxy)‐2,2′:6′,2′′‐terpyridine Cltpy 4′‐chloro‐2,2′:6′,2′′‐terpyridine). Their ability to interact with DNA was investigated, their cytotoxic behaviour examined three cells lines, namely human ovarian carcinoma (A2780), derived...
Cisplatin has been described as a potent anticancer agent for decades. However, in the case of glioblastomas, it is only considered rescue treatment applied after failure second-line treatments. Herein, based on versatility offered by coordination chemistry, we engineered nanoparticles reaction platinum (IV) prodrug and iron metal ions showing vitro dual pH- redox-sensitivity, controlled release comparable cytotoxicity to cisplatin against HeLa GL261 cells. In vivo intranasal administration...
Abstract A new tetradentate ligand, namely 3,3′‐((1 E ,1′ )‐(ethane‐1,2‐diylbis(azaneylylidene))bis(methaneylylidene))bis(pyridin‐2‐amine) ( en2ampy ) was prepared and two copper(II) complexes, viz . [Cu( )]Cl 2 1 )](NO 3 ), were obtained through its reaction with chloride nitrate, respectively. The single‐crystal X‐ray structure of the compounds showed that metal centre coordinated in a square‐planar fashion by doubly deprotonated acting as / ‐donor ligand. DNA‐binding studies revealed...
The need for non-invasive therapies capable of conserving drug efficiency and stability while having specific targetability against colorectal cancer (CRC), has made nanoparticles preferable vehicles principal building blocks the development complex multi-action anti-tumoral approaches. For that purpose, we herein report production a combinatory nanotherapy using new targeting towards CRC lines. To do so, Magneto-fluorescent NANO3 were used as nanocarriers combination drugs doxorubicin (DOX)...
Covalent grafting of diaqua Gd(<sc>iii</sc>)-complexes onto dense silica nanoparticles affords non-toxic contrast agents suitable for high field MRI pre-clinical studies.
Abstract To expand the chemotherapeutic potential of platinum complexes, different approaches have been followed, two most relevant being their administration as prodrug Pt( iv ) and encapsulation in nanocarriers. Herein, we demonstrate how neuromelanin may become a good bioinspiration for synthesis nanoparticles (NPs), combining both approaches. For this, complex PtBC reacts with sodium periodate, inducing melanization process formation nanoparticles. In vitro results on non-malignant human...
The cover feature picture shows the progressive activation of terpyridine-based copper(II) compounds that are not cytotoxic against various cell lines after 24 h incubation but become highly efficient 72 incubation, with IC50 values in low-micromolar to nanomolar range. More information can be found full paper by A. Caubet, P. Gamez, et al.