H1-antihistamines (AHs) may exert protective effects against cancer. This study investigated the association of AH use with risk hepatocellular carcinoma (HCC) in patients hepatitis B virus (HBV), C (HCV), or dual HBV-HCV infection.Patients HBV, HCV, infection were enrolled from Taiwan's National Health Insurance Research Database and examined for period January 1, 2006, to December 31, 2015. We used Kaplan-Meier method Cox proportional hazards regression evaluate between HCC risk.We...

ABSTRACT The risk of psoriasis in diabetic patients has rarely been explored. This study aims to compare the incident with Type 2 diabetes (T2D) who initiate dipeptidyl peptidase‐4 inhibitors (DPP‐4is) or thiazolidinediones (TZDs) those sulfonylureas, most common second‐line glucose‐lowering therapy, addition metformin monotherapy. sequential, propensity‐score‐matched, new‐user comparative effectiveness utilized a target trial emulation framework. It included adults T2D receiving...

Abstract Background Spinal cord injury (SCI) and spinal fracture are major complications in patients with ankylosing spondylitis (AS) who sustain trauma. The purpose of this study was to investigate the incidence, predictors, sequelae trauma AS. Methods This retrospective included AS were admitted for between January 1, 2006, June 30, 2016. compared clinical outcomes group 1: SCI alone, 2: alone (no SCI), 3: both fracture. Results Of 6285 during period, only 105 suffered from enrolled study....

Recent years have seen increased attention being given to Blood Pressure (BP) monitoring. Among all kinds of measurements, the monitors based on Pulse Transit Time (PTT) gain plenty due its continuous and cuffless features. Additionally, several studies proposed a fancy way estimate photoplethysmography (PPG) signal simply via regular webcam. Nevertheless, literatures issues integrating these two advanced techniques emerged slowly scattered way. Furthermore, accuracy BP prediction model PTT...

To successfully increase athletes' or exercisers' fitness and endurance, the factors of physiological signal, emotion, level fatigue should be considered during training program. Many clinical decision support systems can assist to monitor exercisers by some wearable devices. And, questionnaire also taken into account produce a report. Such process is cumbersome, results are not objective. Furthermore, one may feel uncomfortable when wearing devices In this research, Rating Perceived...

Previous studies have shown myasthenia gravis (MG) and autoimmune rheumatic diseases (ARDs) share common pathogenetic mechanisms. Therefore, the present study investigated possible relationship between MG ARDs.We analysed Taiwanese medical data from Registry of Catastrophic Illness identified patients with MG. From entire general population National Health Insurance Research Database, we randomly selected a comparison cohort that was frequency-matched by age (in 5-year increments), sex,...

Background Previous study revealed proton pump inhibitors (PPIs) have an effect on gut microbiota. Alteration of the microbiome causes changes host immune system and then induces development autoimmune diseases (ADs). This aimed to explore possible association between PPIs use ADs. Methods was conducted using data from Taiwan National Health Insurance Research Database in period 2002 2015. We performed multivariate stratified analysis through Kaplan-Meier method Cox proportional hazard...

Recent years have seen increased attention being given to measure Heart Rate with remote-PPG. Previous work mainly focused on optimal signal extraction from three channels of a webcam. Several robust methods using either optic models or frequency analysis been discussed before. After applied these algorithms, residual noise still emerges occasionally short time duration and relative high energy. This paper investigates the cause then proposed an algorithm based continuous wavelet transform...

Abstract Objectives The data concerning the association between Tx and ADs remain unclear are scarce. This study was undertaken to investigate whether people with more likely develop ADs, compared those without Tx. Methods Individuals who received 2002 2015 were identified matched on age sex individuals We performed multivariate stratified analysis using Kaplan–Meier method Cox proportional hazards models in order estimate risk of developing ADs. Results A total 2550 thymectomized (Txd)...

In the last decade, many advances have been made in field of automatic temperature estimation, including wearable sensor technologies (WST), infrared thermography (IRT), and non-contact thermometer (NCIT). contrast with WST IRT, NCIT is inexpensive without risk potential skin irritation. Nevertheless, limited short valid estimation distance (<;12 cm), resulting non-satisfaction surging application requirements nowadays. This paper proposed an algorithm based on Neural Network Regression not...

Abstract Objective We studied the risk of dementia in patients with primary Sjögren's syndrome ( pSS ) using a nationwide, population‐based cohort Taiwan. Methods Our study analyzed medical data Taiwanese population from 2000 to 2014. identified 17,072 and 68,270 controls. Dementia was Cox proportional hazards regression model stratified by sex, age, comorbidities. Results A higher incidence development group during observation period P = 0.0001). In multivariate analysis adjusted age...

Interferon in combination with ribavirin has been the standard of care for chronic hepatitis C virus infection (HCV) past few decades. However, its effect on risk autoimmune diseases (ADs) among patients HCV remains unclear. We assessed potential association between interferon-based therapy (IBT) and AD infection.This retrospective cohort study identified diagnosed January 1, 2006, December 31, 2015, from Taiwan's National Health Insurance Research Database. In total, 16,029 who received IBT...

Abstract Gout is a common metabolic disorder characterized by deposits of monosodium urate monohydrate crystals (tophi) in soft tissue, triggering intense and acute arthritis with intolerable pain as well articular periarticular inflammation. Tophi can also promote chronic inflammatory erosive arthritis. 2015 ACR/EULAR Classification criteria include clinical, laboratory, imaging findings, where cases gout are indicated threshold score ≥ 8. Some imaging-related such double contour sign...

RA damages the joints and increases risks of total knee replacement (TKR) hip (THR). However, benefits biologics in preventing TKR or THR remain unclear.This retrospective nationwide study used 2000-2013 claims-based National Health Insurance dataset. Biologics are reimbursed for refractory cases. The biologic cohort were compared with those an age- sex-matched csDMARD cohort. A multivariate Cox regression model was to investigate bDMARDs THR.TKR performed 5979 cases 11 958 matched controls,...

Objective: Knee osteoarthritis (OA) is common in middle-aged and elderly people. Patients with knee OA can use hyaluronic acid (HA) injection therapy if they meet certain requirements. The purpose of this study was to delineate the effects HA patients identify factors associating efficacy injections by using musculoskletal sonography (MUS). Methods: We included 100 from May 2012 2013. were evaluated MUS 4 5 weeks after receiving a complete course intraarticular injection. Radiographic...

Objectives: To investigate the frequency of Baker's cysts in rheumatoid arthritis (RA). Methods: We retrospectively analyzed clinical and musculoskeletal ultrasound (MUS) findings 150 patients diagnosed with RA according to American College Rheumatology revised criteria. used logistic regression analyze relationship between (1) patient age incidence cyst (2) diameter rupture. In addition, we analysis variance (ANOVA) knee effusion grading cyst. Results: was detected 39 (26%) 48 300 examined...

Abstract Purpose: Infection events can trigger autoimmune responses in several chronic inflammatory diseases; however, no study has focused on their effects patients with enterovirus (EV) infection. We aimed to investigate the association between EV infection and risk of diseases. Materials Methods: used insurance claims data from Taiwan’s National Health Insurance Research Database (NHIRD) disease (AD) incidence or without a diagnosis January 1, 2006, December 31, 2015. Incidence rate...

Arterial blood pressure is one of the important biomedical waveforms that possess lots clinical and pathological information. This paper aims in designing a technique, which called characteristic compression method, to perform almost loss less data for continuous arterial waveforms. method uses spline function interpolate original waveform at preselected sample points first. A fourth order considered with associated formulas describing coefficients function. second stage accompanied by using...

Background: Enterovirus A71 (EV-A71) is causing cyclical epidemics of fatal hand-foot-mouth disease (HFMD) in Taiwan and other Asian countries. Evidence its incidence rates risk factors based on longitudinal cohort studies scarce. This study aims to investigate age-specific cumulative EV71 infections from 2006 2012 northern Taiwan. Methods materials: A total 759 neonates born between 2009 were recruited. Participants' sera collected at their 6, 12, 24, 36, 48, 60, 72 months age conduct serum...