A5048046427- Receptor Mechanisms and Signaling
- PI3K/AKT/mTOR signaling in cancer
- Protein Degradation and Inhibitors
- Advanced Proteomics Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Bacteriophages and microbial interactions
- Metabolism and Genetic Disorders
- Neurological diseases and metabolism
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Biochemical and Molecular Research
Beth Israel Deaconess Medical Center
2022-2024
Harvard University
2022-2024
Cancer Research Institute
2022
University of Massachusetts Dartmouth
2021
In response to hormones and growth factors, the class I phosphoinositide-3-kinase (PI3K) signalling network functions as a major regulator of metabolism growth, governing cellular nutrient uptake, energy generation, reducing cofactor production macromolecule biosynthesis1. Many driver mutations in cancer with highest recurrence, including receptor tyrosine kinases, Ras, PTEN PI3K, pathologically activate PI3K signalling2,3. However, our understanding core metabolic program controlled by is...
More than 50% of human tumors display hyperactivation the serine/threonine kinase AKT. Despite evidence clinical efficacy, therapeutic window current generation AKT inhibitors could be improved. Here, we report development a second-generation degrader, INY-05-040, which outperformed catalytic inhibition with respect to cellular suppression AKT-dependent phenotypes in breast cancer cell lines. A growth screen 288 lines confirmed that INY-05-040 had substantially higher potency our...
Abstract In this case study, phage therapy was applied to treat a multidrug-resistant of septicemic cutaneous ulcerative disease (SCUD) caused by Citrobacter freundii in loggerhead sea turtle Caretta caretta. Phages were topically, intravenously, into the carapace, and exhibit water using various cocktails specific causative agent over an 8-month period. This performed conjunction with antimicrobial therapy. The animal monitored through weekly cultures, photographs, complete blood cell...
Abstract Tyrosine phosphorylation of metabolic enzymes is an evolutionarily conserved post-translational modification that facilitates rapid and reversible modulation enzyme activity, localization or function. Despite the high abundance tyrosine events detected on in high-throughput mass spectrometry-based studies, functional characterization sites has been limited to a subset enzymes. Since dysregulated across human diseases, including cancer, understanding consequences critical for...
Tyrosine phosphorylation of metabolic enzymes is an evolutionarily conserved posttranslational modification that facilitates rapid and reversible modulation enzyme activity, localization, or function. Despite the high abundance tyrosine events detected on in high-throughput mass spectrometry-based studies, functional characterization sites has been limited to a subset enzymes. Since dysregulated across human diseases, including cancer, understanding consequences critical for informing...
Abstract Over 50% of human tumors display hyperactivation the serine/threonine kinase AKT. Despite evidence clinical efficacy, there remains scope to improve upon therapeutic window current generation AKT inhibitors. Here we report development a second-generation degrader, INY-05-040, which outperformed catalytic inhibition with respect cellular suppression AKT-driven phenotypes in breast cancer cell lines. A systematic growth screen across 288 lines confirmed substantially higher potency...