A5063564891- High Altitude and Hypoxia
- Neuroscience of respiration and sleep
- Cancer, Hypoxia, and Metabolism
- Climate Change and Health Impacts
- Cardiovascular Health and Disease Prevention
- Epigenetics and DNA Methylation
- Blood Pressure and Hypertension Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Heme Oxygenase-1 and Carbon Monoxide
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Travel-related health issues
- Dietary Effects on Health
Syracuse University
2019-2025
Vanderbilt University
2025
Genetic and nongenetic factors are involved in the individual ability to physiologically acclimatize high-altitude hypoxia through processes that include increased heart rate ventilation. High-altitude acclimatization is thought have a genetic component, yet it unclear if other factors, such as epigenetic gene regulation, nonacclimatized individuals. We collected saliva samples from group of healthy adults European ancestry (n = 21) Kathmandu (1,400 m; baseline) three altitudes during trek...
The human spleen contracts in response to stress-induced catecholamine secretion, resulting a temporary rise haemoglobin concentration ([Hb]). Recent findings highlighted enhanced splenic exercise at high altitude Sherpa, possibly due blunted hypoxia. To explore the potential contraction Sherpas altitude, we examined changes volume during hyperoxic breathing, comparing acclimatized Sherpa with individuals of lowland ancestry. Our study included 14 non-Sherpa (7 female) residing for mean...
Abstract Objectives The Sherpa ethnic group living at altitude in Nepal may have experienced natural selection response to chronic hypoxia. We previously shown that Kathmandu (1400 m) possess larger spleens and a greater apnea‐induced splenic contraction compared lowland Nepalis. This be significant for exercise capacity as the human spleen responds stress‐induced catecholamine secretion by an immediate contraction, which results transiently elevated hemoglobin concentration ([Hb]). Methods...
With over 14 million people living above 3,500 m, the study of acclimatization and adaptation to high altitude in human populations is increasing importance, where exposure (HA) imposes a blood oxygenation acid–base challenge. A sustained augmented hypoxic ventilatory response protects through acclimatization, but elicits hypocapnia respiratory alkalosis. subsequent renally mediated compensatory metabolic acidosis corrects pH toward baseline values, with degree interindividual variability....
The individual physiological response to high-altitude hypoxia involves both genetic and non-genetic factors, including epigenetic modifications. Epigenetic changes in factor pathway (HIF) genes are associated with acclimatization. However, genome-wide that short-term exposure remain largely unknown. We collected a series of DNA samples from 15 participants European ancestry trekking Everest Base Camp identify methylation incremental altitude ascent. determined levels using the Illumina...
Background: High altitude sojourn challenges blood flow regulation in the brain, which may contribute to cognitive dysfunction. Neurovascular coupling (NVC) describes ability increase working regions of brain. Effects high on NVC frontal undergoing activation are unclear but be relevant executive function high-altitude hypoxia. This study sought examine effect incremental ascent very by measuring anterior cerebral artery (ACA) and middle (MCA) hemodynamic responses sustained activity....
Cognitive function may be negatively impacted at high-altitude, which has important implications for decision making in such environments. The ability to predict changes cognitive high-altitude safeguard against potential adverse events both novice and experienced trekkers. Hypoxia results compensatory increases cerebral blood flow maintain oxygen delivery. An inability increase this setting contribute performance high-altitude. Cerebral reactivity hypoxia low-altitude thus a useful...