A5014599903- Respiratory viral infections research
- Virology and Viral Diseases
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Mesenchymal stem cell research
- Virus-based gene therapy research
- Mosquito-borne diseases and control
- Immune Cell Function and Interaction
- Salmonella and Campylobacter epidemiology
- vaccines and immunoinformatics approaches
- Neonatal Respiratory Health Research
- Viral Infections and Vectors
- Vibrio bacteria research studies
- RNA Interference and Gene Delivery
- Pneumonia and Respiratory Infections
- Tissue Engineering and Regenerative Medicine
- Listeria monocytogenes in Food Safety
- Vector-Borne Animal Diseases
- Venomous Animal Envenomation and Studies
- Retinal and Optic Conditions
- IL-33, ST2, and ILC Pathways
- Cancer Cells and Metastasis
Sultan Qaboos University
2025
Yale University
2024
The Ohio State University
2009-2018
University of Minnesota
2005-2016
College of Wooster
2014
Mesenchymal stem (stromal) cells (MSCs) mediate their immunoregulatory and tissue repair functions by secreting paracrine factors, including extracellular vesicles (EVs). In several animal models of human diseases, MSC-EVs mimic the beneficial effects MSCs. Influenza viruses cause annual outbreaks acute respiratory illness resulting in significant mortality morbidity. constantly evolve, thus generating drug-resistant strains rendering current vaccines less effective against newly generated...
ABSTRACT Pigs are capable of generating reassortant influenza viruses pandemic potential, as both the avian and mammalian can infect pig epithelial cells in respiratory tract. The source current is H1N1 A virus, possibly swine origin. This study was conducted to understand better pathogenesis virus associated host mucosal immune responses during acute infection humans. Therefore, we chose a Sw/OH/24366/07 (SwIV), which has history transmission Clinically, inoculated pigs had nasal discharge...
Salmonella enterica continues to be a significant cause of foodborne gastrointestinal illness in humans. A wide variety serovars have been isolated from production birds and retail poultry meat. Recently, though, S. subsp. serovar Kentucky has emerged as one the prominent broiler chickens. Recent work suggests that its emergence apparently coincides with acquisition ColV virulence plasmid. In present study, we examined 902 isolates belonging 59 different for presence this Of examined,...
Infectious bursal disease (IBD) is an important immunosuppressive of chickens. The causative agent, infectious virus (IBDV), consists two serotypes, 1 and 2. Serotype classic IBDV (cIBDV) variant (vIBDV). Both these strains vary in antigenicity pathogenesis. goal this study was to compare the immunopathogenesis cIBDV vIBDV. Three-week-old specific pathogen free chickens were inoculated intraocularly with standard challenge strain (STC) a Indiana (IN) produced more pronounced damage,...
Mesenchymal stem cells (MSCs) are multipotent progenitor found in bone marrow that have the capacity of differentiating into bone, cartilage, fat, muscle, and other tissues. Chicken MSCs were isolated from 1- to 14-day-old chickens. Microscopically, cultured showed morphology resembling fibroblasts divided actively. expressed transcription factors PouV, Sox2, Nanog, which been shown be critical for cell self-renewal pluripotency. The multilineage differentiation potential chicken was...
Infectious bursal disease virus (IBDV) infects and replicates in the dividing B lymphocytes of chickens. In present study, vivo effect IBDV infection on chicken macrophage populations activation were examined. Specific-pathogen–free chickens exposed to virulent splenic macrophages recovered during acute phase disease. At 3 5 days post-infection (dpi), spleens virus-exposed had fewer than those virus-free controls (p < 0.05). Confocal microscopic examination revealed cells that positive for...
Abstract Background The genetic features that facilitate Campylobacter jejuni ’s adaptation to a wide range of environments are not completely defined. However, whole genome expression studies showed respiratory proteins (RPs) were differentially expressed under varying conditions and stresses, suggesting further unidentified roles for RPs in C . adaptation. Therefore, our objectives characterize the contributions selected i- key survival phenotypes different temperature (37°C vs. 42°C)...
Abstract Background Human Bocavirus (HBoV) was first identified in 2005 among children suffering from acute respiratory symptoms. It is frequently detected as a co-infecting virus, and the degree to which it causes symptoms unclear. Little known about its epidemiology Middle East. Methods Children who presented Sultan Qaboos University Hospital, Muscat, Oman between January, 2018 December, 2019, with were tested for viruses reviewed. Respiratory specimens using FTD Pathogens 21 Assay...
Infectious bursal disease (IBD) is a highly contagious of chickens which leads to immunosuppression. In our previous study it was demonstrated that, possibly, CD4(+) and CD8(+) T cells may employ perforin granzyme-A pathway for the clearance IBDV-infected cells. this study, we evaluated cytotoxic cell responses involving two independently functioning but complementary mechanisms: Fas-Fas ligand perforin-granzyme pathways in chickens. As previously, infection with IBDV accompanied by influx...
Mesenchymal stromal cells (MSCs) have differentiation, immunomodulatory, and self-renewal properties are, therefore, an attractive tool for regenerative medicine autoimmune diseases. MSCs may be of great value to treat graft-versus-host disease. Influenza virus causes highly contagious seasonal infection occasional pandemics. The is severe in children, elderly, immunocompromised hosts including hematopoietic stem cell transplant patients. objective this study was determine if are permissive...
We isolated stem/progenitor epithelial cells from the lungs of 4- to 6-week-old pigs. The progenitor colony were surrounded by mesenchymal stromal cells. expressed stem cell markers such as octamer binding transcription factor 4 (Oct4) and stage-specific embryonic antigen 1 (SSEA-1), well pancytokeratin, cytokeratin-18, occludin, but not (CD44, CD29, CD90) hematopoietic (CD45) markers. had extensive self-renewal potential capacity undergo differentiation alveolar type I- II-like pneumocytes....
Ocular lesions are common in red-tailed hawks with West Nile (WN) disease. These consist of pectenitis, choroidal or retinal inflammation, necrosis, but detailed investigation the ocular is lacking. Postmortem examination eyes 16 naturally acquired WN disease and 3 without was performed using histopathology, immunohistochemistry for virus (WNV) antigen, glial fibrillary acid protein, cleaved caspase-3, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling method. Retinal were...
The methylmenaquinol:fumarate reductase (Mfr) of Campylobacter jejuni is a periplasmic respiratory (redox) protein that contributes to the metabolism fumarate and displays homology succinate dehydrogenase (Sdh). Since chemically oxidized redox-enzymes, including Sdh, contribute generation oxidative stress in Escherichia coli, we assessed role Mfr C. after exposure hydrogen peroxide (H2O2). Our results show mutant (∆mfrA) strain was less susceptible H2O2 as compared wildtype (WT)....