A5045177567- Natural Antidiabetic Agents Studies
- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Medicinal Plants and Bioactive Compounds
- Nigella sativa pharmacological applications
- Pharmacological Effects of Natural Compounds
- Saffron Plant Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Bioactive Compounds and Antitumor Agents
- Phytochemicals and Antioxidant Activities
- Cardiomyopathy and Myosin Studies
- Medicinal Plants and Neuroprotection
- Exercise and Physiological Responses
- Peptidase Inhibition and Analysis
- Immune Response and Inflammation
- Cardiac electrophysiology and arrhythmias
- Metabolism, Diabetes, and Cancer
- Phytochemistry and Biological Activities
- Advanced Glycation End Products research
- Cardiovascular and exercise physiology
- Diet, Metabolism, and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Ginger and Zingiberaceae research
Mashhad University of Medical Sciences
2015-2024
Torbat Heydarieh University of Medical Sciences
2024
Université Libre de Bruxelles
2008-2013
Objective. The aim of this study was to elucidate the mechanism(s) responsible for vasorelaxant effect Nigella sativa ( N. ). Methods. activity different concentrations extract evaluated on contractile responses isolated aorta KCl and phenylephrine (PE). Results. (2–14 mg/mL) induced a concentration dependent relaxation both in endothelium-intact endothelium-denuded aortic rings precontracted by PE (10 −6 M) (6 × 10 −2 M). Extract reduced PE- KCl-induced contractions presence cumulative...
Background: Exercise training could be essential in preventing pathological cardiac remodeling diabetes. Therefore, the effects of moderate-intensity continuous (MICT) and high-intensity interval (HIIT) singly or plus metformin on diabetes-induced cardiomyopathy were investigated this study. Methods: Forty-nine Wistar rats (male) recruited. Seven groups animals treated for six weeks as control, diabetes, MICT (15 m/min, 40 min/day), HIIT (20 (300 mg/kg), HIIT+metformin (Met-HIIT),...
Diabetic cardiomyopathy (DCM) is a chronic complication of diabetes that emphasizes the urgency developing new drug therapies. With an illustrious history in traditional medicine to improve diabetes, cinnamon has been shown possess blood lipids lowering effects and antioxidative anti-inflammatory properties. However, extent which it protects diabetic heart yet be determined. Forty-eight rats were administered study grouped as: control; diabetic; given 100, 200, or 400 mg/kg extract,...
Abstract Sepsis is associated with brain injury and acute inflammation, which can potentially transition into chronic triggering a cascade of inflammatory responses that may lead to neurological disorders. Minocycline, recognized for its potent anti‐inflammatory properties, was investigated in this study protective effects against sepsis‐induced injury. Adult male C57 mice pretreated minocycline (12.5, 25, 50 mg/kg) 3 days before sepsis induction. An intraperitoneal injection 5 mg/kg LPS...
Introduction: Inadequate control of diabetes mellitus (DM) leads to considerable cardiovascular implications like diabetic cardiomyopathy (DCM). Cardiomyocyte apoptosis is one the main mechanisms DCM pathogenesis associated with hyperglycemia, oxidative stress, inflammation, hyperlipidemia and several other factors. Trigonella foenum-graecum (Fenugreek) has been long used as a traditional medicine many therapeutic effects, including anti-diabetic, anti-hyperlipidemia, anti-inflammatory...
Diabetic cardiomyopathy (DCM), as a ventricular dysfunction, is one of the main causes death in diabetic patients. Former evidence revealed beneficial effects exercise on cardiovascular complications diabetes. We aimed to investigate high-intensity interval training (HIIT) and moderate-intensity continuous (MICT) DCM. Male Wistar rats were divided into control, diabetic, metformin (300 mg/kg), HIIT, MICT, + MICT groups. Serum biochemical, inflammatory, oxidative stress indicators, gene...
Heart failure is a cause of pulmonary vasoconstriction and remodelling, leading to hypertension (PH) decreased survival. The pathobiology PH in heart remains incompletely understood. We investigated vascular function signalling molecules early stage secondary experimental failure. Eight beagle dogs with overpacing‐induced underwent haemodynamic assessment postmortem arterial reactivity, morphometry quantification genes encoding for factors involved reactivity remodelling: endothelin‐1...
Background The antidiabetic and antioxidant effects of Trigonella foenum-graceum have been suggested. hydroalcoholic extract the plant seeds metformin against diabetes-induced memory impairment were investigated. Materials methods rats treated: (1) control, (2) diabetic (3-6) treated by 50, 100 200 mg/kg or metformin. streptozotocin (STZ, 55 mg/kg). After passive avoidance test, malondialdehyde (MDA), nitric oxide (NO) metabolites, total thiol (SH), catalase (CAT) superoxide dismutase (SOD)...
There are some reports about protective effects of Achillea on the heart. We investigated effect wilhelmsii extract cardiac function during ischemia–reperfusion (I/R) injury in isolated rat 60 male Wistar rats were randomly divided into 6 groups; 1: Control group, 2: Control-ischemia (CI) 3: vitamin C (10 mg/kg), 4–6: Extract groups (E 100, E 200 and 400 mg/kg). The animals received normal saline, or A. orally for 4 weeks. At end treatment, hearts subjected to vitro I/R Injury (20 min global...
Inflammatory process and apoptosis are involved in the pathogenesis of cardiac injury oxidative damage caused by diabetes mellitus. The cardioprotective effects standardized aqueous ethanolic olive leaf extract (OLE), metformin (as a cardiovascular protective agent) valsartan an angiotensin receptor blocker) streptozotocin-induced diabetic rats were evaluated.Wistar divided into control, diabetic, OLE-treated (100, 200 400 mg/kg), (300 mg/kg)-treated, (30 mg/kg)-treated...