A5054456462- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer, Hypoxia, and Metabolism
- Blood groups and transfusion
- Lung Cancer Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Head and Neck Cancer Studies
- Vitamin D Research Studies
- Cancer-related gene regulation
- Anesthesia and Pain Management
- Axon Guidance and Neuronal Signaling
- Colorectal and Anal Carcinomas
- Neuroblastoma Research and Treatments
Oregon Health & Science University
2021-2023
Albert Einstein College of Medicine
2013-2022
Montefiore Medical Center
2021
Long Island Jewish Medical Center
2020
Northwell Health
2020
The Bronx Defenders
2013-2019
Moffitt Cancer Center
2016
Molecular Oncology (United States)
2016
Abstract B7-H3 (CD276) is an important immune checkpoint member of the B7 and CD28 families. Induced on antigen-presenting cells, plays role in inhibition T-cell function. Importantly, highly overexpressed a wide range human solid cancers often correlates with both negative prognosis poor clinical outcome patients. Challenges remain to identify receptor(s) thus better elucidate pathway responses tumor evasion. With preferential expression attractive target for cancer immunotherapy. Based...
T-cell costimulation and coinhibition generated by engagement of the B7 family their receptor CD28 are central importance in regulating response, making these pathways very attractive therapeutic targets. Here we describe HERV–H LTR-associating protein 2 (HHLA2) as a member that shares 10–18% amino acid identity 23–33% similarity to other human proteins phylogenetically forms subfamily with B7x B7-H3 within family. HHLA2 is expressed humans but not mice, which unique families. constitutively...
Abstract Purpose: HHLA2 (B7H7/B7-H5/B7y) is a newly identified B7 family member that regulates human T-cell functions. However, its protein expression in organs and significance diseases are unknown. The objective of this study was to analyze normal tissues cancers, as well prognostic significance, explore mechanisms regulating expression, identify candidate receptors. Experimental Design: An immunohistochemistry protocol flow cytometry assay with generated monoclonal antibodies were...
Coronavirus disease 2019 (COVID-19) has infected more than 4.4 million people and caused 300,000 deaths partly through acute respiratory distress syndrome with propensity to affect African American Hispanic communities disproportionately. Patients worse outcomes have exhibited higher blood plasma levels of proinflammatory cytokines. Activation the vitamin D receptor expressed on immune cells been shown directly reduce secretion inflammatory cytokines, such as interleukin-6, indirectly...
Epithelial-mesenchymal transition (EMT) is one mechanism of acquired resistance to inhibitors the epidermal growth factor receptor-tyrosine kinases (EGFR-TKIs) in non-small cell lung cancer (NSCLC). The precise mechanisms EMT-related EGFR-TKIs NSCLC remain unclear. We generated erlotinib-resistant HCC4006 cells (HCC4006ER) by chronic exposure EGFR-mutant increasing concentrations erlotinib. HCC4006ER an EMT phenotype and activation TGF-β/SMAD pathway, while lacking both T790M secondary EGFR...
B7x (B7-H4 or B7S1) is a member of the B7 family that can inhibit T cell function. protein absent in most normal human tissues and immune cells, but it overexpressed cancers often correlates with negative clinical outcome. The expression pattern function suggest may be potent immunosuppressive pathway cancers. Here, we determined crystal structure immunoglobulin variable (IgV) domain at 1.59 Å resolution mapped epitopes recognized by monoclonal antibodies. We developed an vivo system to...
Abstract Immune checkpoint molecules play critical roles in regulating the anti-tumor immune response, and tumor cells often exploit these pathways to inhibit evade system. The B7-family B7x is widely expressed a broad variety of cancer types, generally associated with advanced disease progression poorer clinical outcomes, but underlying mechanisms are unclear. Here, we show that transduction stable expression multiple syngeneic models leads expansion immunosuppressive regulatory T (Tregs)....
B7x (B7-H4 or B7S1) is an inhibitory member of the B7 family T cell costimulation. It expressed in low levels healthy peripheral tissues, such as lung epithelium, but overexpressed a variety human cancers with negative clinical associations, including metastasis. However, function context cancer, whether on cancer cells surrounding "host" has not been elucidated vivo. We used 4T1 metastatic breast model and knockout (B7x (-/-)) mice to investigate effect host tissue-expressed cancer. found...
Activation of the inflammatory transcription factor NF-κB in tumor-associated macrophages (TAMs) is assumed to contribute tumor promotion. However, whether and how drives antitumor become pro-tumorigenic have not been determined any cancer type yet. Similarly, TAMs repress CD8+ cytotoxic T lymphocytes (CTLs) remains largely unknown, although their importance regulatory (Treg) cell regulation promotion has well appreciated. Here, using an endogenous lung model we uncover a direct crosstalk...
// Kim C. Ohaegbulam 1 , Weifeng Liu 2 Hyungjun Jeon Steven Almo 2, 3 and Xingxing Zang 1, 4, 5 Department of Microbiology Immunology, Albert Einstein College Medicine, Bronx, NY, USA Biochemistry, Physiology Biophysics, 4 Urology, Correspondence to: Zang, email: xingxing.zang@einstein.yu.edu Keywords: B7x, immune checkpoint, pulmonary metastases, CD8 T cells, innate cells Received: July 12, 2017 Accepted: August 29, Published: September 20, ABSTRACT B7x (B7-H4 or B7S1) is a coinhibitory...
A new study demonstrates the tumorigenic functions of B7x and reveals a link between myeloid-derived suppressor cells (MDSCs) within tumor microenvironment. We propose that binding to hitherto unidentified receptor on MDSCs may stimulate their proliferation and/or immunosuppressive functions, hence promoting growth.
Abstract Introduction Circulating tumour human papillomavirus DNA (ctHPVDNA) is an emerging tool to assess post‐treatment response in patients with HPV+ oropharyngeal squamous cell carcinoma (OPSCC). Its use not a standard practice, however, interval F‐18 FDG PET/CT and fiberoptic examination preferred. Post‐treatment at 3 months has low positive predictive value (PPV), especially OPSCC treated (chemo)radiation therapy (CRT). We aimed compare 3–6 month ctHPVDNA test results determine the...
Lung cancer is the second most common and leading cause of cancer-related deaths. Despite recent advances in development targeted therapies, patients with advanced disease remain incurable, mostly because metastatic non-small cell lung carcinomas (NSCLC) eventually become resistant to tyrosine kinase inhibitors (TKIs). Kinase have potential for target promiscuity super family largest druggable genes that binds a substrate (ATP). As result, TKIs often developed specific purpose been found act...
Background: The rate of cesarean delivery is on the rise in USA. Satisfactory postoperative analgesia remains a top priority for delivery. Multimodal with reduction opioid consumption and improvement patient satisfaction goal anesthesiologists caring this population. Our study sought to assess whether IV acetaminophen four divided doses over 24 h decreased pain scores requirements patients undergoing neuraxial anesthesia.Methods: 66 elective under spinal anesthesia hyperbaric bupivacaine 12...
Objectives: Approximately 15% of patients with localized prostate cancer are at high risk for disease recurrence. Many clinical trials have evaluated the impact neoadjuvant therapy before radical prostatectomy mixed results (NCT00321698). Methods: This phase I/II trial tolerability and preliminary efficacy radiation docetaxel in 25 men high-risk cancer. The treatment regimen included 45 Gy radiotherapy fractions to seminal vesicles over 5 weeks, along weekly dose-escalated up 30 mg/m²,...
e15127 Background: In CRC, utility of immunotherapy (IT) remains limited to persons with microsatellite instability–high (MSI-H) status. Immunotyping CRC patients is critical towards further establishing IT's potential. Both incidence and survival rates for in the United States vary between races due multiple factors including genetic heterogeneity. this study, we have profiled tumor samples a racially diverse population expression four different members B7 family immune check point...
July 1, 2019, was a monumental day for recent medical school graduates. Pulsating emotions of anxiety, excitement, and insecurity flowed through our bodies as we traversed wards newly minted physicians. We embarked on rigorous year-long journey in cementing the foundations principles general medicine, perfectly situated Queens, NY, most ethnically diverse area world. A scenario fit complex diseases because ultimate ambitions were necessarily paused. preliminary year residency is, by design,...
<p>Supplementary Figure 1: Stained controls from IHC protocol development.</p>
<p>Table S1. Expression of cell surface HHLA2 protein in various human cells lines determined by flow cytometry.</p>