A5041579923- Cellular Mechanics and Interactions
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Barrier Structure and Function Studies
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Viral-associated cancers and disorders
- RNA modifications and cancer
- DNA Repair Mechanisms
- MicroRNA in disease regulation
- Immune cells in cancer
- Extracellular vesicles in disease
Centre de Recerca en Sanitat Animal
2025
Universitat Autònoma de Barcelona
2025
Institute for Bioengineering of Catalonia
2020-2021
Barcelona Institute for Science and Technology
2020-2021
Universitat de Girona
2021
Universitat de Barcelona
2020
École Polytechnique Fédérale de Lausanne
2019
Extracellular vesicles (EVs), including exosomes, modulate multiple aspects of cancer biology. Tumor-associated macrophages (TAMs) secrete EVs, but their molecular features and functions are poorly characterized. Here, we report methodology for the enrichment, quantification, proteomic lipidomic analysis EVs released from mouse TAMs (TAM-EVs). Compared to source TAMs, TAM-EVs present profiles associated with a Th1/M1 polarization signature, enhanced inflammation immune response, more...
Plitidepsin is an antitumoral compound safe for treating COVID-19 that targets the translation elongation factor eEF1A. Here we detect plitidepsin decreases de novo cap-dependent of SARS-CoV-2 and non-viral RNAs but affects less than 13% host proteome, thus preserving cellular viability. In response to plitidepsin, cells upregulate EIF2AK3 proteins reduce translation, also support proteostasis via ribosome synthesis cap-independent by eIF4G2 IGF2BP2. While inhibits cap- or internal entry...
Intestinal organoids capture essential features of the intestinal epithelium such as folding crypt, spatial compartmentalization different cell types, and cellular movements from crypt to villus-like domains. Each these processes their coordination in time space requires patterned physical forces that are currently unknown. Here we map three-dimensional cell-ECM cell-cell mouse grown on soft hydrogels. We show exhibit a non-monotonic stress distribution defines mechanical functional...
Despite the significant advances in cancer research made recent years, this disease remains one of leading causes death worldwide. In part, is due to fact that after therapy, a subpopulation self-renewing tumor cells can survive and promote relapse, resistance therapies metastasis. Targeting these stem (CSCs) therefore essential improve clinical outcome patients. sense, multi-targeted drugs may be promising agents targeting CSC-associated multifocal effects. We have previously constructed...