A5035020718- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Language, Discourse, Communication Strategies
- Linguistic research and analysis
- Epigenetics and DNA Methylation
- Discourse Analysis in Language Studies
- Language, Metaphor, and Cognition
- Misinformation and Its Impacts
- Linguistic Variation and Morphology
- Neurobiology of Language and Bilingualism
- Language Development and Disorders
- Epistemology, Ethics, and Metaphysics
- Prion Diseases and Protein Misfolding
- Child and Animal Learning Development
- Syntax, Semantics, Linguistic Variation
University of Göttingen
2018-2025
The incidence of Alzheimer's disease (AD), the leading cause dementia, increases rapidly with age, but why age constitutes main risk factor is still poorly understood. Brain ageing affects oligodendrocytes and structural integrity myelin sheaths1, latter which associated secondary neuroinflammation2,3. As support axonal energy metabolism neuronal health4-7, we hypothesized that loss could be an upstream for amyloid-β (Aβ) deposition, central neuropathological hallmark AD. Here identify...
In Alzheimer's disease (AD) research, the 5xFAD mouse model is commonly used as a heterozygote crossed with other genetic models to study AD pathology. We investigated whether parental origin of transgene affects plaque deposition. Using quantitative light-sheet microscopy, we found that paternal inheritance led 2-fold higher burden compared maternal inheritance, finding consistent across multiple colonies. This effect was not due gestation in or rearing by females. Immunoblotting suggested...
The prevalence of Alzheimer’s disease (AD), the leading cause dementia, shows a strict age-dependency, but why ageing constitutes main risk factor for this is still poorly understood. Brain affects oligodendrocytes 1 and structural integrity myelin sheaths 2 , latter associated with secondary neuroinflammation 3 . Since support axonal neuronal health 4–7 we hypothesised that ageing-associated loss could be an upstream amyloid-β (Aβ) deposition, primary neuropathological hallmark AD. Here,...
The discussion on whether some conversational implicatures (CIs) are more ‘default’ than the other has taken place for a long time. While neo-Griceans (NG) insist distinction between generalized and particularized CIs, which said to differ along numerous dimensions, so far, most studies focusing computational speed showed any enrichment is costly literal understanding, therefore challenge PCIs GCIs. In this study, novel approach – deceptive language with false was used test speakers of...