A5049209946- RNA Research and Splicing
- Micro and Nano Robotics
- Microtubule and mitosis dynamics
- PI3K/AKT/mTOR signaling in cancer
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Lipid Membrane Structure and Behavior
- Signaling Pathways in Disease
- Tuberous Sclerosis Complex Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Hereditary Neurological Disorders
- Modular Robots and Swarm Intelligence
- Pickering emulsions and particle stabilization
- Endoplasmic Reticulum Stress and Disease
- Heat shock proteins research
- Cellular transport and secretion
National Institutes of Health
2023
National Institute of Neurological Disorders and Stroke
2023
International Institute of Molecular and Cell Biology
2020-2021
Max Planck Institute of Molecular Cell Biology and Genetics
2017-2020
Max Bergmann Zentrum für Biomaterialien
2016
Stressed cells shut down translation, release mRNA molecules from polysomes, and form stress granules (SGs) via a network of interactions that involve G3BP. Here we focus on the mechanistic underpinnings SG assembly. We show that, under non-stress conditions, G3BP adopts compact auto-inhibited state stabilized by electrostatic intramolecular between intrinsically disordered acidic tracts positively charged arginine-rich region. Upon unfolded mRNAs outcompete auto-inhibitory interactions,...
Article4 April 2017Open Access Transparent process An aberrant phase transition of stress granules triggered by misfolded protein and prevented chaperone function Daniel Mateju Max Planck Institute Molecular Cell Biology Genetics, Dresden, Germany Search for more papers this author Titus M Franzmann Avinash Patel Andrii Kopach Edgar E Boczek Shovamayee Maharana Hyun O Lee Serena Carra Department Biomedical, Metabolic Neural Sciences, University Modena Reggio Emilia, Modena, Italy Anthony A...
Ras GTPase-activating protein-binding proteins 1 and 2 (G3BP1 G3BP2, respectively) are widely recognized as core components of stress granules (SGs). We report that G3BPs reside at the cytoplasmic surface lysosomes. They act in a non-redundant manner to anchor tuberous sclerosis complex (TSC) protein lysosomes suppress activation metabolic master regulator mechanistic target rapamycin (mTORC1) by amino acids insulin. Like TSC complex, G3BP1 deficiency elicits phenotypes related mTORC1...
Self-propelled Janus particles, acting as microscopic vehicles, have the potential to perform complex tasks on a scale, suitable, e.g., for environmental applications, on-chip chemical information processing, or in vivo drug delivery. Development of these smart nanodevices requires better understanding how synthetic swimmers move crowded and confined environments that mimic actual biosystems, network blood vessels. Here, dynamics self-propelled particles interacting with catalytically...
Combining catalytic Janus swimmers and passive beads in narrow channels, L. Baraban co-workers observe many dynamic properties, ranging from distinct bulk boundary-free diffusivity at low densities, whereby a swimmer transports large clusters of particles. This research (on page 5882) is an important milestone towards understanding further fabrication realistic bioinspired complex networks, containing synthetic autonomous micro- nano- machines to perform the tasks mixture with objects. Image...
ABSTRACT Oligodendrocytes have elaborate arbors of microtubules that extend toward axons and spiral around myelin sheaths. rely on satellite organelles called Golgi outposts to nucleate new at sites far from the cell body. We now show outpost marker TPPP (tubulin polymerization promoting protein) forms liquid condensates co-partition with tubulin in order microtubules. In oligodendrocytes, either dynamic puncta or aberrant microtubule-associated aggregates. Multiple System Atrophy (MSA), a...
Summary G3BP1 (Ras GTPase-activating protein-binding protein 1) is widely recognized as a core component of stress granules (SG), non-membranous RNA-protein-assemblies required for cellular survival under stress. We report that in the absence SG, acts lysosomal anchor Tuberous Sclerosis Complex (TSC) complex. By tethering TSC complex to lysosomes, suppresses signaling through metabolic master regulator mTORC1 (mechanistic target rapamycin 1). Like known subunits, phenotypes related...