A5029878487- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Immunotherapy and Immune Responses
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Skin Protection and Aging
- Cell Adhesion Molecules Research
- Contact Dermatitis and Allergies
- Autoimmune Bullous Skin Diseases
- Wound Healing and Treatments
- Skin and Cellular Biology Research
- Allergic Rhinitis and Sensitization
- Neuropeptides and Animal Physiology
- Nerve injury and regeneration
- Viral-associated cancers and disorders
- HIV Research and Treatment
- T-cell and B-cell Immunology
- Sphingolipid Metabolism and Signaling
- Food Allergy and Anaphylaxis Research
- Histiocytic Disorders and Treatments
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- HIV/AIDS Research and Interventions
- Corneal Surgery and Treatments
- Parvovirus B19 Infection Studies
Istituti di Ricovero e Cura a Carattere Scientifico
1995-2020
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2014-2020
University of Modena and Reggio Emilia
2008-2019
Azienda Ospedaliero-Universitaria di Modena
1990-2010
University of Verona
2010
University of Pavia
1974-2006
University of Amsterdam
2006
University of Padua
2006
University of Michigan
2003
Istituto Dermopatico dell'Immacolata
1995-2002
Psoriasis is a chronic inflammatory disease associated with an increased cardiovascular risk. Metabolic syndrome significant predictor of events.To investigate the prevalence metabolic in patients psoriasis.We performed hospital-based case-control study on 338 adult plaque psoriasis and 334 skin diseases other than psoriasis.Metabolic was significantly more common psoriatic controls (30.1% vs. 20.6%, odds ratio 1.65, 95% confidence interval 1.16-2.35; P = 0.005) after age 40 years. Psoriatic...
Atopic dermatitis skin tends to be easily irritated and appears dry. These clinical peculiarities correspond impaired barrier function increased transepidermal water loss (TEWL) values. A few studies suggest that a reduced amount of total ceramides (especially ceramide 1) is responsible for functional abnormalities the atopic patients. The aim this study was analyze relationship between epidermal lipids impairment in patients with dermatitis. quantity ceramides, cholesterol sulphate free 47...
The molecular mechanism underlying the promotion of wound healing by TGF-beta 1 is incompletely understood. We report that regulates regenerative/migratory phenotype normal human keratinocytes modulating their integrin receptor repertoire. In growing keratinocyte colonies but not in fully stratified cultured epidermis, 1: (a) strongly upregulates expression fibronectin alpha 5 beta 1, vitronectin v 5, and collagen 2 differentially synthesis subunits; (b) downregulates multifunctional 3...
Recently a new classification of primary cutaneous B-cell lymphomas (PCBCLs) has been proposed by the European Organization for Research and Treatment Cancer (EORTC)--Cutaneous Lymphoma Project Group. The marginal zone (MZLs) were not included as distinct entity because insufficient experience controversial opinions. We have studied 32 patients (M:F ratio 1.5:1; age range 25-93 years; mean 49.6 median 50 years) to determine diagnostic criteria MZL relationship with other low-grade malignant...
Long-term treatment for atopic dermatitis (AD) using low dose, intermittent, topical anti-inflammatory agents may control acute disease and prevent relapses. This 12-month, European, multicentre, randomized study investigated whether the proactive use of 0.1% tacrolimus ointment applied twice weekly can keep AD in remission reduce incidence exacerbations (DE).During initial open-label period, 257 adults with daily (b.i.d.) up to 6 weeks affected areas. When an Investigator Global Assessment...
Our aim was to assess the role of body mass index (BMI) in clinical response systemic treatment for psoriasis.A nationwide cohort study patients receiving a new plaque psoriasis at reference centres Italy conducted. Information gathered through web-based electronic form. Patients being maintained on same medication and with data available 8 16 weeks by March 31, 2007, were eligible. The outcome reduction Psoriasis Area Severity Index (PASI) least 75% follow-up compared baseline (PASI-75).Out...
Lesional skin of atopic dermatitis (AD) harbors high numbers dendritic cells with enhanced stimulatory capacity for T lymphocytes. In this study, lesional AD was shown to stain heavily in both epidermal and dermal compartments GM-CSF, a cytokine crucial cell functions. Keratinocyte cultures established from uninvolved patients exhibited markedly increased spontaneous PMA-stimulated release GM-CSF compared keratinocytes nonatopic controls. Correspondingly, showed higher constitutive as well...
We report a long-term follow-up (6.5 years) of phase I/II clinical trial envisaging the use autologous genetically modified cultured epidermal stem cells for gene therapy junctional epidermolysis bullosa, devastating genetic skin disease. The critical goals were to evaluate safety and persistence epidermis. A normal epidermal-dermal junction was restored regenerated transgenic epidermis found be fully functional virtually indistinguishable from control. sustained by discrete number...
In order to identify and characterize the sonographic variations between different age groups, 48 subjects, 24 aged 27–30, over 60, were studied with a 20-MHz B scanner on six skin sites. Images evaluated by instrument’s standard programme new image analysis software package enabling characterization of steady structures or transitory functional aspects reactions, highlighting areas in which echo amplitudes are included within selected values, calculating their extension. Three...
The distribution and localization of several neuropeptides were investigated in the lichenified lesions 11 patients with atopic dermatitis using indirect immunofluorescence. Substance P-positive nerve fibres observed most cases dermatitis, but not normal controls. Somatostatin immunoreactive nerves found skin whereas a pattern immunoreactivity could be detected healthy subjects. Neuropeptide Y-positive dendritic epidermal cells lesional from Calcitonin gene-related peptide vasoactive...
Background: Long‐term treatment for atopic dermatitis (AD) using low dose, intermittent, topical anti‐inflammatory agents may control acute disease and prevent relapses. This 12‐month, European, multicentre, randomized study investigated whether the proactive use of 0.1% tacrolimus ointment applied twice weekly can keep AD in remission reduce incidence exacerbations (DE). Methods: During initial open‐label period, 257 adults with daily (b.i.d.) up to 6 weeks affected areas. When an...
An observational study was conducted to estimate the incidence of psoriasis in Italy, as well utilization healthcare resources and association with selected comorbidities patients. The data source Health Search/Thales Database, containing computer-based patient records from over 900 primary care physicians (PCPs) throughout Italy. cohort comprised all adults receiving a first-ever diagnosis during years 2001-2005. From total sample 511,532 individuals, 2.30-3.21 cases per 1,000 person-years....
Abstract Objective To evaluate variations in laboratory parameters and diagnoses of selected clinical conditions up to 16 weeks after starting a new systemic psoriasis treatment for Psocare Registry enrollees. Design Prospective cohort study. Setting Italian public referral centres treatment. Patients First‐time recipients ( n = 10,539) continuous at least weeks. Main outcome measure Mean (weeks 8 16) proportions patients reaching clinically meaningful increase serum levels (week total...
Normal human keratinocytes synthesize and release nerve growth factor (NGF) express both the low- high-affinity NGF receptor. Because has been shown to rescue certain cell types from programmed death, we investigated role of endogenous in preventing keratinocyte apoptosis. We report here that apoptosis is induced normal culture by blocking signaling with either anti-NGF neutralizing antibody or K252, a specific inhibitor tyrosine kinase Apoptosis was assessed DNA laddering, electron...
Abstract Objective Our objectives were to determine the prevalence of psychological distress in a large sample Italian patients with psoriasis; establish whether disease severity and are associated; identify strategies employed cope evaluate coping by dermatologists; potential predictors distress. Design Cross‐sectional. Setting Thirty‐nine dermatology centres. Subjects One thousand five hundred eighty (1580) psoriasis. Methods Minor was evaluated using General Health Questionnaire‐12...
Because inhibition of integrin signaling induces apoptosis, we investigated whether keratinocytes expressing beta1 and alpha6beta4 integrins (enriched for stem cells) are protected from cell death. Keratinocytes rapidly adhering to type IV collagen expressed highest levels the anti-apoptotic marker p63. Apoptotic cells were significantly higher in slowly than keratinocytes. Anti-beta1 caused a significant increase apoptotic cells, while it decreased Bcl-2 Bax Bad proteins cells. By contrast,...
Adults with atopic dermatitis (AD), respiratory atopy only and healthy non-atopic controls were given intradermal injections of substance P (SP), neurokinin A (NKA), neurotensin (NT), vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) histamine into the normal-appearing skin on back. The weal flare responses evaluated after 3, 5 15 min areas calculated using an automatic image analyser. With three different concentrations used (1,3 30 pmols) a statistically...