A5039753914- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Healthcare and Venom Research
- Nanoparticle-Based Drug Delivery
- Cancer, Lipids, and Metabolism
- Sleep and related disorders
- Traditional Chinese Medicine Studies
- Autophagy in Disease and Therapy
- Cancer, Stress, Anesthesia, and Immune Response
- Traditional Chinese Medicine Analysis
- Lipid metabolism and disorders
- Nanoplatforms for cancer theranostics
- Obesity, Physical Activity, Diet
- Genetic Associations and Epidemiology
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
Guangdong Medical College
2023-2024
Heilongjiang University of Chinese Medicine
2024
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2024
Reprogramming of lipid metabolism, which modulates energy utilization and cell signaling, maintains survival promotes cancer metastasis in cells. Ferroptosis is a type necrosis caused by an overload oxidation, has been demonstrated to be involved metastasis. However, the mechanism fatty acid metabolism regulates anti-ferroptosis signaling pathways not fully understood. The formation ovarian spheroids helps counteract hostile microenvironment peritoneal cavity with low oxygen, shortage...
Emerging evidence highlights the multifaceted contributions of m6A modifications to glioma. IGF2BP3, a modification reader protein, plays crucial role in post-transcriptional gene regulation. Though several studies have identified IGF2BP3 as poor prognostic marker glioma, underlying mechanism remains unclear. In this study, we demonstrated that knockdown is detrimental cell growth and survival glioma cells. Notably, discovered regulated ferroptosis by modulating protein expression level GPX4...
Abstract Glioma, a malignant brain tumor originating from neural glial cells, presents significant treatment challenges. However, the underlying mechanisms of glioma development are not fully understood, and effective targets lacking. This study provides insights into role insulin‐like growth factor 2 messenger RNA‐binding protein (IGF2BP2) in progression its therapeutic potential. Our analysis illustrated that elevated IGF2BP2 expression associated with significantly shorter survival among...
Objective This study aimed to investigate the causal relationship between insomnia and risk of myocardial infarction (MI) explore potential mediators such as smoking initiation, alcohol consumption body mass index (BMI) using mendelian randomization (MR) analysis. Methods Data from 1,207,228 individuals European ancestry were obtained UK Biobank 23andMe for insomnia-related genetic associations. Genetic instruments MI, consumption, BMI derived large-scale genome-wide association studies....