A5000299760- Material Dynamics and Properties
- Glass properties and applications
- Theoretical and Computational Physics
- Lymphoma Diagnosis and Treatment
- Ionic liquids properties and applications
- Fluorine in Organic Chemistry
- CAR-T cell therapy research
- Lichen and fungal ecology
- Liquid Crystal Research Advancements
- Cyclopropane Reaction Mechanisms
- Analytical Chemistry and Chromatography
- Chemical Synthesis and Analysis
- Cancer Immunotherapy and Biomarkers
- Chemical Thermodynamics and Molecular Structure
- Phase-change materials and chalcogenides
- Asymmetric Synthesis and Catalysis
- Monoclonal and Polyclonal Antibodies Research
- T-cell and Retrovirus Studies
- Ovarian cancer diagnosis and treatment
- Bryophyte Studies and Records
- Viral-associated cancers and disorders
- Evaluation of Teaching Practices
- Innovative Teaching Methods
- thermodynamics and calorimetric analyses
- Innovative Teaching and Learning Methods
Mayo Clinic in Arizona
2024
Mayo Clinic
2023
University of West Florida
2022
Marcus (United States)
2022
University of Tennessee at Knoxville
2021
Louisiana State University of Alexandria
2015
University of Wisconsin–Madison
2010-2013
University of Rostock
2012
Stonehill College
2011
Murray State University
1980
Highly stable glass films of indomethacin (IMC) with thicknesses ranging from 75 to 2900 nm were prepared by physical vapor deposition. Alternating current (AC) nanocalorimetry was used evaluate the heat capacity and kinetic stability glasses as a function thickness. Glasses deposited at substrate temperature 0.84T(g) displayed capacities that approximately 19 J/(mol K) (4.5%) lower than T(g) (315 or ordinary cooling liquid. This difference in observed over entire thickness range is...
Vapor-deposited glasses of toluene and ethylbenzene have been characterized by in situ ac chip-nanocalorimetry. The high sensitivity this method allows the detection small changes heat capacity nanogram size samples. We observe that vapor-deposited up to 4% lower capacities than ordinary glass. largest decrease most kinetically stable are observed a range deposition temperatures between 0.75 T(g) 0.96 T(g). Compared larger molecules, rate has minor influence on kinetic stability these...
In situ AC nanocalorimetry was used to measure the reversing heat capacity of vapor-deposited glasses decahydronaphthalene (decalin). Glasses with low and high kinetic stability, as compared corresponding liquid-cooled glass, were prepared from cis-decalin several cis/trans-decalin mixtures. This is first report highly stable glass formation for molecular The 50/50 mixture highest fragility material reported produce an ultrastable glass. exhibited a ∼500 nm film deposited at 116 K (0.86 Tg)...
The reversing heat capacity of vapor-deposited o-terphenyl glasses was determined by in situ alternating current nanocalorimetry. Glasses were deposited at substrate temperatures ranging from 0.39 Tg to Tg, where is the glass transition temperature. near 0.85 exhibited very high kinetic stability; a 460 nm film required ∼104.8 times structural relaxation time equilibrium supercooled liquid transform into state. For most stable glasses, lower than that ordinary liquid-cooled (1 ± 0.4)%; this...
Physical vapor deposition can be used to produce thin films with interesting material properties including extraordinarily stable organic glasses. We describe an ac chip calorimeter for in situ heat capacity measurements of as-deposited nanometer glass formers. The calorimetric system is based on a differential which placed the vacuum chamber physical deposition. sample directly deposited onto one sensor while other protected against device and temperature calibration procedure are...
Two new bicyclobutanes were prepared from cyclobutyl systems by a novel, solvolytic, carbocation-based methodology. An electron-withdrawing perfluoroalkyl group at the incipient cationic center enhances neighboring-group participation of γ-silyl group, inducing facile, remarkably selective 1,3-elimination yielding only bicyclobutanes. The method unlocks potential access to host EWG-substituted strained rings and for synthesis trifluoromethylcyclopropanes.
The reversing heat capacity of vapor-deposited glasses α,α,β-tris-naphthylbenzene (ααβ-TNB) was measured using alternating current (AC) nanocalorimetry. Glasses deposited at 0.85 Tg, where Tg is the glass transition temperature, have a 4 ± 1% lower than ordinary prepared by cooling from liquid. This result efficient packing and consistent with higher density glass. Isothermal experiments show that ααβ-TNB also enhanced kinetic stability respect to transformation into supercooled liquid, as...
Sarcocystosis was diagnosed in 41 eighteen-month-old heifers and steers. Clinical signs included anorexia, severe weight loss, nervousness, hypersalivation, lameness, hair loss on the extremities. Hair noticed especially at end of tail, where there complete switch, giving animals a "rat-tail" appearance. Consistent gross changes observed necropsy four affected generalized lymphadenopathy, erosions ulcerations oral cavity esophagus, laminitis. Microscopically, young cysts Sarcocystis sp were...
Introduction: Histologic transformation (HT) is a singular event in the natural history of patients with follicular lymphoma (FL) which dramatically change clinical course and portends poor prognosis. Efforts to date understanding pathobiology HT FL (HT-FL) have been focused on genomic factors leading clonal evolution cells. In present study we aimed investigate contribution host immune system HT-FL. Methods: Patients newly diagnosed grade 1-3a were prospectively enrolled Molecular...
Moss sporophytes are physically attached to and dependent on the leafy gametophyte through their entire life. During early development, sporophyte apex is covered by calyptra, a cap of gametophytic tissue which protects developing capsule. The aim this study examine influence calyptra transpiration rates in mosses. We used two laboratory-grown species with different sizes for study: Funaria hygrometrica Hedw. Physcomitrium pyriforme (Hedw.) Hampe. When was removed from apex, there were...
Abstract The method includes [2 + 2] cycloaddition, fluoroalkylation by the Prakash method, tosylation and solvolysis.
Introduction: Despite advances, 20%–40% of patients with DLBCL do not achieve remission or relapse after an initial response. We aimed to identify immunological factors associated early clinical failure in DLBCL. Methods: Patients treated rituximab and anthracycline-based chemotherapy were prospectively enrolled the University Iowa/Mayo Clinic Lymphoma Specialized Program Research Excellence (SPORE). Tissue microarrays (TMAs) containing specimens from diagnosis analyzed using Digital Spatial...
Introduction: The prognosis for patients with relapsed or refractory aggressive B-cell non-Hodgkin lymphoma (r/r B-NHL) is poor. efficacy of combining nivolumab (PD-1 inhibitor) and varlilumab (CD27 agonist) was tested in this population the multi-center randomized phase II DIAL study (Dual Immunomodulation Aggressive Lymphoma). Methods: Patients r/r B-NHL were to treatment alone combined (Figure 1A). Cross-over (group 1 2) allowed progression. Primary endpoint overall response (ORR) per...