A5034041534- Advanced Breast Cancer Therapies
- Gastric Cancer Management and Outcomes
- HER2/EGFR in Cancer Research
- Acute Myeloid Leukemia Research
- Cancer Treatment and Pharmacology
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Esophageal and GI Pathology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Liver Disease Diagnosis and Treatment
- Tracheal and airway disorders
- Gastrointestinal Tumor Research and Treatment
- Asthma and respiratory diseases
- Spectroscopy Techniques in Biomedical and Chemical Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Liver Disease and Transplantation
- Foreign Body Medical Cases
- AI in cancer detection
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- Animal Genetics and Reproduction
- Airway Management and Intubation Techniques
- Rheumatoid Arthritis Research and Therapies
Fudan University
2012-2025
Zhongshan Hospital
2020-2025
University of Macau
2021-2025
University of Science and Technology of China
2024
South China Institute of Collaborative Innovation
2022-2024
Guangxi University
2019-2023
Gilead Sciences (United States)
2020-2023
Xinjiang Agricultural University
2023
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2022-2023
People's Hospital of Shiyan
2022
Gastroscopic biopsy provides the only effective method for gastric cancer diagnosis, but gold standard histopathology is time-consuming and incompatible with gastroscopy. Conventional stimulated Raman scattering (SRS) microscopy has shown promise in label-free diagnosis on human tissues, yet it requires tuning of picosecond lasers to achieve chemical specificity at cost time complexity. Here, we demonstrate that single-shot femtosecond SRS (femto-SRS) reaches maximum speed sensitivity...
Core-needle biopsy (CNB) plays a vital role in the initial diagnosis of breast cancer.However, complex tissue processing and global shortage pathologists have hindered traditional histopathology from timely on fresh biopsies.In this work, we developed full digital platform by integrating label-free stimulated Raman scattering (SRS) microscopy with weakly-supervised learning for rapid automated cancer un-labelled CNB.Methods: We first compared results SRS imaging standard hematoxylin eosin...
Gibberellins (GAs) are the key regulators controlling plant growth, wood production and stress responses in perennial woody plants. The role of GA regulating above-mentioned processes Eucalyptus remain largely unclear. There is still a lack systematic identification functional characterization GA-related genes Eucalyptus. In this study, total 59,948 expressed were identified from major vegetative tissues E. grandis × urophylla using transcriptome sequencing. Then, gene families each step...
ABSTRACT Background and Aim This work aims to evaluate the efficacy safety of free‐hand endoscopic full‐thickness resection (EFTR) for duodenal subepithelial lesions (SELs). Methods We performed a retrospective review 105 patients with SELs who underwent EFTR. Free‐hand EFTR means no other devices (over‐the‐scope clip or device) are required. The preoperative baseline data, procedure‐related characteristics, postoperative outcomes were analyzed. Results technical success rate was 99.0%, en...
Abstract Background Esophageal Squamous Cell Carcinoma (ESCC) was characterized as a regional-prevalent and aggressive tumor with high morbidity mortality. NIMA-related kinase 2 (NEK2) is an interesting oncogene, the alteration of which leads to patients-beneficial outcomes. We aimed explore role NEK2 in ESCC excavate its mechanism. Methods RNA-seq data were downloaded from TCGA GEO analyzed by R software. The protein levels detected immunohistochemistry (IHC) or western blot (WB), mRNA...
Abstract Background Type C hepatitis B-related acute-on-chronic liver failure (HBV-ACLF), which is based on decompensated cirrhosis, has different laboratory tests, precipitating events, organ and clinical outcomes. The predictors of prognosis for type HBV-ACLF patients are from those other subgroups. This study aimed to construct a novel, short-term prognostic score that applied serological indicators hepatic regeneration noninvasive assessment fibrosis predict outcomes in with HBV-ACLF....
Gastrointestinal stromal tumors (GISTs) are among the most common submucosal in stomach that require therapeutic intervention. We aim to identify predictors of technical difficulty during endoscopic resection gastric GIST and investigate follow-up outcomes.Patients with GISTs were reviewed from June 2009 2020 at Zhongshan Hospital. Clinical pathological features, procedure information, data collected analyzed. A nomogram was developed validated internally externally.A total 628 finally The...
Abstract Background The effects of filgotinib on patient-reported outcomes (PROs) from 3 trials in patients with active rheumatoid arthritis were investigated. Methods Methotrexate (MTX)-naïve received 200 or 100 mg plus MTX (FIL200+MTX, FIL100+MTX), monotherapy (FIL200), through 52 weeks (NCT02886728). Patients inadequate response (IR) to (MTX-IR) FIL200+MTX, FIL100+MTX, adalimumab 40 +MTX (ADA+MTX), placebo (PBO)+MTX (rerandomized FIL200+MTX FIL100+MTX at week 24) (NCT02889796). IR...
With the social networks (SNs) becoming ubiquitous and massive, issue of similarity computation among entities becomes more challenging draws extensive interests from various research fields. SimRank is a well known measure, however it considers only meetings between two nodes that walk along equal length paths since path increases strictly with iteration increasing during computation, besides, does not differentiate importance for each link. In this paper, we propose novel structural E-Rank...
RIB + endocrine therapy (ET) had a significant OS benefit vs. placebo (PBO) in pts with HR+/HER2− ABC the ML-3 (postmenopausal pts; HR, 0.71; P = .00973; Slamon et al. N Engl J Med. 2020) and ML-7 (premenopausal 0.72; .00455; Im 2019) trials. Dose reductions to manage adverse events (AEs) were allowed; prior analysis showed no impact on progression-free survival dose reduction (Beck, SABCS 2018). Here we present data evaluate -7. randomized 2:1 or PBO (both fulvestrant). 1:1 ET); only...