A5078728656- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Photoreceptor and optogenetics research
- Hepatitis C virus research
- Laser Applications in Dentistry and Medicine
- Advanced MRI Techniques and Applications
- Ion channel regulation and function
- Cell Image Analysis Techniques
- Advanced Fluorescence Microscopy Techniques
- HIV Research and Treatment
- Cardiovascular Function and Risk Factors
- Retinopathy of Prematurity Studies
- Pluripotent Stem Cells Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cell death mechanisms and regulation
- Cardiac Imaging and Diagnostics
- Hepatitis B Virus Studies
- Neuroscience of respiration and sleep
- 3D Printing in Biomedical Research
- Redox biology and oxidative stress
- Genetic Neurodegenerative Diseases
- Metabolomics and Mass Spectrometry Studies
- Neuroscience and Neuropharmacology Research
Lena Biosciences (United States)
2020
Tsinghua University
2013
Peking University
2006-2012
Center for Life Sciences
2012
Beijing National Laboratory for Molecular Sciences
2009
An inexorable loss of terminally differentiated heart muscle cells is a crucial causal factor for failure. Here, we have provided several lines evidence to demonstrate that mitofusin-2 (Mfn-2; also called hyperplasia suppressor gene), member the mitofusin family, major determinant oxidative stress-mediated cardiomyocyte apoptosis. First, stress with H2O2 led concurrent increases in Mfn-2 expression and apoptosis cultured neonatal rat cardiomyocytes. Second, overexpression level similar...
Mitochondria in many types of cells are dynamically interconnected through constant fusion and fission, allowing for exchange mitochondrial contents repair damaged mitochondria. However, constrained by the myofibril lattice, ∼6,000 mitochondria adult mammalian cardiomyocyte display little motility, it is unclear how, if at all, they communicate with each other. By means target-expressing photoactivatable green fluorescent protein (PAGFP) matrix or on outer membrane, we demonstrated that...
Abstract Acute hepatitis C virus (HCV) infection culminates in viral persistence the majority of cases. Abs that recognize envelope glycoproteins E1 and E2 are generated during late stages acute infection, yet their contribution to spontaneous clearance remains controversial. Investigation humoral responses HCV have been limited by inability directly identify characterize HCV-specific B cells. In this study we describe development a novel tetramer glycoprotein ectodomain (J6, genotype 2a...
Remarkable advances in three-dimensional (3D) cell cultures and organ-on-a-chip technologies have opened the door to recapitulate complex aspects of human physiology, pathology, drug responses vitro. The challenges regarding oxygen delivery, throughput, assay multiplexing, experimental complexity are addressed ensure that perfused 3D culture models become a routine research tool adopted by academic industrial stakeholders. To move field forward, we present throughput-scalable insert system...