A5101774713- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Inflammatory Bowel Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- NF-κB Signaling Pathways
- Inflammatory mediators and NSAID effects
- Helicobacter pylori-related gastroenterology studies
- Genomics, phytochemicals, and oxidative stress
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Bioactive Compounds and Antitumor Agents
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Natural product bioactivities and synthesis
- Protease and Inhibitor Mechanisms
- Pharmacological Effects of Natural Compounds
- Estrogen and related hormone effects
- Adipokines, Inflammation, and Metabolic Diseases
- Mast cells and histamine
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- Skin Protection and Aging
- Synthesis and biological activity
- Neuroscience and Neuropharmacology Research
Yeungnam University
2016-2025
Government of the Republic of Korea
2016-2018
Silla University
2014-2016
Korea Research Institute of Bioscience and Biotechnology
2015
Korea Institute of Energy Research
2014
Carbon Engineering (Canada)
2014
Pukyong National University
2008-2013
Rockefeller University
2012-2013
Brandeis University
2005-2012
Kyungpook National University
2011
Abstract Transcription factor NRF2 is an important modifier of cellular responses to oxidative stress. Although its cytoprotective effects are firmly established, recent evidence suggesting roles in cancer pathobiology has yet be mechanistically developed. In the current study, we investigated role colon tumor angiogenesis. Stable RNAi-mediated knockdown human cells suppressed growth mouse xenograft settings with a concomitant reduction blood vessel formation and VEGF expression. Similar...
Double-strand break (DSB) damage in yeast and mammalian cells induces the rapid ATM (ataxia telangiectasia mutated)/ATR Rad3 related)-dependent phosphorylation of histone H2AX (γ-H2AX). In budding yeast, a single endonuclease-induced DSB triggers γ-H2AX modification 50 kb on either side DSB. The extent spreading does not depend chromosomal sequences. DNA resection after formation causes slow, progressive loss from single-stranded and, several hours, Mec1 (ATR)-dependent to more distant...
Triple-negative breast cancer (TNBC) has a high risk of relapse and there are few chemotherapy options. Although 5-hydroxytryptamine (5-HT, serotonin) signaling pathways have been suggested as potential targets for anti-cancer drug development, the mechanism responsible action 5-HT in TNBC remains unknown.Quantitative real-time polymerase chain reaction (qRT-PCR) Western blotting were used to measure mRNA protein levels, respectively. Cell proliferation was measured using CellTiter 96...
The function of regulatory T (Treg) cells depends on lipid oxidation. However, the molecular mechanism by which Treg maintain metabolism after activation remains elusive. Liver kinase B1 (LKB1) acts as a coordinator linking cellular to substrate AMP-activated protein (AMPK). We show that deletion LKB1 in exhibited reduced suppressive activity and developed fatal autoimmune inflammation. Mechanistically, induced mevalonate pathway upregulating genes, was essential for cell functional...
The volatile extract from dried pericarp of Zanthoxylum schinifolium that was obtained by simultaneous distillation with dichloromethane and water composed 29.9% geranyl acetate, 15.8% citronella, 15.4% sabinene the minor components included β-myrcene, linalool, (−)-isopulegol, citronellyl 1,4-dimethyl pyrazole, α-terpinene, 3-methyl-6-(1-methylethyl)-2-cyclo-hexene-1-o1 trans-geraniol. decreased cell viability induced apoptotic death in HepG2 human hepatoma cells a concentration-...
In response to a DNA double-strand break (DSB), chromatin is rapidly modified by the damage dependent checkpoint kinases. Also, disassembly of occurs at site. The damage-induced modification structure involved in maintenance checkpoint. However, it has not been determined how restored its undamaged state when DSB repair complete. Here, we show involvement two assembly factors (CAFs), Asf1 and CAF-1, turning off budding yeast. or formation γ-H2AX does depend on either CAF-1 protein, Cac1,...
The emergence of antibiotic resistance has necessitated new therapeutic approaches for combating persistent bacterial infection. An alternative approach is regulation virulence instead growth suppression, which can readily lead to drug resistance. the opportunistic human pathogen Pseudomonas aeruginosa depends on a large number extracellular factors and biofilm formation. Thirty-one natural synthetic indole derivatives were screened. 7-fluoroindole (7FI) was identified as compound that...
Bacterial biofilms are associated with persistent infections due to their high resistance antimicrobial agents. Hence, controlling pathogenic biofilm formation is important in bacteria-related diseases. Honey, at a low concentration of 0.5% (v/v), significantly reduced enterohemorrhagic Escherichia coli O157:H7 without inhibiting the growth planktonic cells. Conversely, this did not inhibit commensal E. K-12 formation. Transcriptome analyses showed that honey repressed curli genes (csgBAC),...
Although matrix metalloproteinase (MMP)-7 expression is correlated with increased metastatic potential in human colon cancer cells, the underlying molecular mechanism of invasive phenotype remains unknown. In current study, we investigated regulatory effects membrane NADPH oxidase (NOX) and AMP activated protein kinase (AMPK) on MMP-7 change cells.Production superoxide anion was measured by lucigenin chemiluminescence assay using whole cells extracts (NADPH activity), intracellular reactive...
Although capsaicin (8-methyl-N-vanillyl-6-nonenamide), a pungent ingredient in variety of red peppers the genus Capsicum, has been shown to induce apoptotic cell death many cancer cells, exact mechanism this action is not completely understood. In study, we investigated possible mediation NADPH oxidase-modulated production reactive oxygen species (ROS) HepG2 human hepatoblastoma cells. Capsaicin induced time- and dose-dependent manner. at concentration inducing apoptosis also markedly...